| Full name: protein tyrosine phosphatase non-receptor type 14 | Alias Symbol: PEZ | ||
| Type: protein-coding gene | Cytoband: 1q32.3-q41 | ||
| Entrez ID: 5784 | HGNC ID: HGNC:9647 | Ensembl Gene: ENSG00000152104 | OMIM ID: 603155 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PTPN14:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTPN14 | 5784 | 226282_at | 0.4119 | 0.4943 | |
| GSE20347 | PTPN14 | 5784 | 205503_at | 0.3191 | 0.0014 | |
| GSE23400 | PTPN14 | 5784 | 205503_at | 0.3059 | 0.0000 | |
| GSE26886 | PTPN14 | 5784 | 226282_at | 1.0981 | 0.0000 | |
| GSE29001 | PTPN14 | 5784 | 205503_at | 0.2728 | 0.0863 | |
| GSE38129 | PTPN14 | 5784 | 205503_at | 0.5319 | 0.0000 | |
| GSE45670 | PTPN14 | 5784 | 226282_at | 0.1555 | 0.4813 | |
| GSE53622 | PTPN14 | 5784 | 153217 | 0.4924 | 0.0000 | |
| GSE53624 | PTPN14 | 5784 | 153217 | 0.6999 | 0.0000 | |
| GSE63941 | PTPN14 | 5784 | 226282_at | -0.1215 | 0.8968 | |
| GSE77861 | PTPN14 | 5784 | 226282_at | 0.8569 | 0.0306 | |
| GSE97050 | PTPN14 | 5784 | A_24_P2648 | 0.1129 | 0.7484 | |
| SRP007169 | PTPN14 | 5784 | RNAseq | 1.4122 | 0.0019 | |
| SRP008496 | PTPN14 | 5784 | RNAseq | 1.5943 | 0.0000 | |
| SRP064894 | PTPN14 | 5784 | RNAseq | 0.3621 | 0.0668 | |
| SRP133303 | PTPN14 | 5784 | RNAseq | 0.4022 | 0.1114 | |
| SRP159526 | PTPN14 | 5784 | RNAseq | 0.3851 | 0.3139 | |
| SRP193095 | PTPN14 | 5784 | RNAseq | 0.8228 | 0.0000 | |
| SRP219564 | PTPN14 | 5784 | RNAseq | -0.1843 | 0.6323 | |
| TCGA | PTPN14 | 5784 | RNAseq | 0.0260 | 0.7508 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PTPN14 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTPN14:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTPN14 | 5784 | 9 | 1 | 20 | |
| GSE20123 | PTPN14 | 5784 | 9 | 1 | 20 | |
| GSE43470 | PTPN14 | 5784 | 7 | 1 | 35 | |
| GSE46452 | PTPN14 | 5784 | 3 | 1 | 55 | |
| GSE47630 | PTPN14 | 5784 | 15 | 0 | 25 | |
| GSE54993 | PTPN14 | 5784 | 0 | 6 | 64 | |
| GSE54994 | PTPN14 | 5784 | 14 | 0 | 39 | |
| GSE60625 | PTPN14 | 5784 | 0 | 0 | 11 | |
| GSE74703 | PTPN14 | 5784 | 7 | 1 | 28 | |
| GSE74704 | PTPN14 | 5784 | 3 | 1 | 16 | |
| TCGA | PTPN14 | 5784 | 43 | 5 | 48 |
Total number of gains: 110; Total number of losses: 17; Total Number of normals: 361.
Somatic mutations of PTPN14:
Generating mutation plots.
Highly correlated genes for PTPN14:
Showing top 20/1296 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTPN14 | METTL23 | 0.81684 | 3 | 0 | 3 |
| PTPN14 | RILPL2 | 0.78789 | 3 | 0 | 3 |
| PTPN14 | PELI2 | 0.7681 | 3 | 0 | 3 |
| PTPN14 | ZDHHC7 | 0.758338 | 3 | 0 | 3 |
| PTPN14 | PPP1R35 | 0.757315 | 3 | 0 | 3 |
| PTPN14 | NPNT | 0.756703 | 4 | 0 | 4 |
| PTPN14 | CASC4 | 0.755445 | 3 | 0 | 3 |
| PTPN14 | RPTOR | 0.753424 | 3 | 0 | 3 |
| PTPN14 | PHIP | 0.74535 | 5 | 0 | 4 |
| PTPN14 | UCN | 0.741828 | 3 | 0 | 3 |
| PTPN14 | MAN1A1 | 0.736466 | 3 | 0 | 3 |
| PTPN14 | GNS | 0.733618 | 4 | 0 | 4 |
| PTPN14 | FAM20C | 0.732464 | 3 | 0 | 3 |
| PTPN14 | ZBED1 | 0.730291 | 3 | 0 | 3 |
| PTPN14 | KLHL13 | 0.726118 | 3 | 0 | 3 |
| PTPN14 | TRIM47 | 0.723507 | 3 | 0 | 3 |
| PTPN14 | TMED8 | 0.721718 | 4 | 0 | 3 |
| PTPN14 | PFKM | 0.717584 | 4 | 0 | 4 |
| PTPN14 | TMEM216 | 0.708218 | 3 | 0 | 3 |
| PTPN14 | ZBTB39 | 0.707871 | 3 | 0 | 3 |
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