STK3

 

Full name: serine/threonine kinase 3 Alias Symbol: MST2|KRS1
Type: protein-coding gene Cytoband: 8q22.2
Entrez ID: 6788 HGNC ID: HGNC:11406 Ensembl Gene: ENSG00000104375 OMIM ID: 605030
Drug and gene relationship at DGIdb
Screen Evidence:

 

STK3 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04390Hippo signaling pathway

 

Expression of STK3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 STK3 6788 204068_at 1.1300 0.1004
GSE20347 STK3 6788 204068_at 1.1888 0.0000
GSE23400 STK3 6788 204068_at 0.9416 0.0000
GSE26886 STK3 6788 204068_at 1.6095 0.0000
GSE29001 STK3 6788 204068_at 1.1497 0.0000
GSE38129 STK3 6788 204068_at 0.9666 0.0000
GSE45670 STK3 6788 204068_at 0.9108 0.0002
GSE53622 STK3 6788 75193 0.9952 0.0000
GSE53624 STK3 6788 75193 0.8604 0.0000
GSE63941 STK3 6788 204068_at 0.3481 0.4561
GSE77861 STK3 6788 204068_at 1.7190 0.0007
GSE97050 STK3 6788 A_33_P3260669 0.3351 0.2423
SRP007169 STK3 6788 RNAseq 0.8407 0.0380
SRP008496 STK3 6788 RNAseq 0.6168 0.0112
SRP064894 STK3 6788 RNAseq 1.0241 0.0000
SRP133303 STK3 6788 RNAseq 0.8320 0.0000
SRP159526 STK3 6788 RNAseq 1.1849 0.0004
SRP193095 STK3 6788 RNAseq 0.9247 0.0000
SRP219564 STK3 6788 RNAseq 0.4147 0.1716
TCGA STK3 6788 RNAseq 0.3026 0.0000

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by STK3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of STK3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 STK3 6788 16 0 14
GSE20123 STK3 6788 17 0 13
GSE43470 STK3 6788 21 1 21
GSE46452 STK3 6788 23 0 36
GSE47630 STK3 6788 24 0 16
GSE54993 STK3 6788 0 20 50
GSE54994 STK3 6788 38 1 14
GSE60625 STK3 6788 0 4 7
GSE74703 STK3 6788 18 1 17
GSE74704 STK3 6788 12 0 8
TCGA STK3 6788 56 2 38

Total number of gains: 225; Total number of losses: 29; Total Number of normals: 234.  

 

Somatic mutations of STK3:

 

Generating mutation plots.

 

Highly correlated genes for STK3:

 

Showing top 20/2156 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
STK3PTK20.8328711011
STK3MTERF30.815922908
STK3LAPTM4B0.81551511011
STK3CCDC1270.801328303
STK3FMNL20.78494706
STK3CMSS10.779286606
STK3ZNF3170.779279303
STK3TAF20.77658711010
STK3CPT1A0.775601303
STK3ENY20.77525711011
STK3GEMIN50.771868404
STK3SLC25A320.77131112011
STK3FZD60.768907909
STK3GNG100.767093303
STK3U2SURP0.764937909
STK3LRP120.76327411011
STK3PUF600.76184511011
STK3ZBTB90.761242404
STK3DPY19L40.76055313012
STK3MRPL140.759969404

For details and further investigation, click here