| Full name: chromodomain helicase DNA binding protein 2 | Alias Symbol: FLJ38614|DKFZp547I1315|DKFZp781D1727|DKFZp686E01200 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 1106 | HGNC ID: HGNC:1917 | Ensembl Gene: ENSG00000173575 | OMIM ID: 602119 |
| Drug and gene relationship at DGIdb | |||
Expression of CHD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHD2 | 1106 | 225077_at | -0.1242 | 0.7831 | |
| GSE20347 | CHD2 | 1106 | 203461_at | -0.0074 | 0.9349 | |
| GSE23400 | CHD2 | 1106 | 203461_at | -0.1371 | 0.0000 | |
| GSE26886 | CHD2 | 1106 | 225077_at | 0.0564 | 0.8422 | |
| GSE29001 | CHD2 | 1106 | 203461_at | -0.2287 | 0.1641 | |
| GSE38129 | CHD2 | 1106 | 203461_at | -0.1586 | 0.0344 | |
| GSE45670 | CHD2 | 1106 | 225077_at | -0.1141 | 0.4314 | |
| GSE53622 | CHD2 | 1106 | 25039 | -0.2331 | 0.0001 | |
| GSE53624 | CHD2 | 1106 | 25039 | -0.1604 | 0.0001 | |
| GSE63941 | CHD2 | 1106 | 225077_at | 0.0449 | 0.9248 | |
| GSE77861 | CHD2 | 1106 | 225077_at | 0.5132 | 0.0311 | |
| GSE97050 | CHD2 | 1106 | A_24_P85317 | -0.0236 | 0.9310 | |
| SRP007169 | CHD2 | 1106 | RNAseq | 0.3974 | 0.2674 | |
| SRP008496 | CHD2 | 1106 | RNAseq | 0.2916 | 0.2270 | |
| SRP064894 | CHD2 | 1106 | RNAseq | -0.3530 | 0.1200 | |
| SRP133303 | CHD2 | 1106 | RNAseq | 0.1199 | 0.3788 | |
| SRP159526 | CHD2 | 1106 | RNAseq | -0.2673 | 0.1499 | |
| SRP193095 | CHD2 | 1106 | RNAseq | 0.0915 | 0.4612 | |
| SRP219564 | CHD2 | 1106 | RNAseq | -0.2946 | 0.4335 | |
| TCGA | CHD2 | 1106 | RNAseq | -0.1314 | 0.0014 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CHD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHD2 | 1106 | 8 | 2 | 20 | |
| GSE20123 | CHD2 | 1106 | 8 | 2 | 20 | |
| GSE43470 | CHD2 | 1106 | 4 | 4 | 35 | |
| GSE46452 | CHD2 | 1106 | 3 | 7 | 49 | |
| GSE47630 | CHD2 | 1106 | 8 | 11 | 21 | |
| GSE54993 | CHD2 | 1106 | 4 | 6 | 60 | |
| GSE54994 | CHD2 | 1106 | 8 | 7 | 38 | |
| GSE60625 | CHD2 | 1106 | 4 | 0 | 7 | |
| GSE74703 | CHD2 | 1106 | 3 | 3 | 30 | |
| GSE74704 | CHD2 | 1106 | 3 | 3 | 14 | |
| TCGA | CHD2 | 1106 | 18 | 13 | 65 |
Total number of gains: 71; Total number of losses: 58; Total Number of normals: 359.
Somatic mutations of CHD2:
Generating mutation plots.
Highly correlated genes for CHD2:
Showing top 20/224 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHD2 | RNF19B | 0.774801 | 3 | 0 | 3 |
| CHD2 | PCDH19 | 0.763244 | 3 | 0 | 3 |
| CHD2 | RECK | 0.759821 | 4 | 0 | 4 |
| CHD2 | SST | 0.759555 | 3 | 0 | 3 |
| CHD2 | MTX3 | 0.75863 | 3 | 0 | 3 |
| CHD2 | KIAA0895L | 0.746171 | 3 | 0 | 3 |
| CHD2 | LIPF | 0.743363 | 3 | 0 | 3 |
| CHD2 | DENND1B | 0.733576 | 3 | 0 | 3 |
| CHD2 | AFAP1L2 | 0.728322 | 3 | 0 | 3 |
| CHD2 | DOCK7 | 0.725013 | 3 | 0 | 3 |
| CHD2 | SPRED1 | 0.723659 | 3 | 0 | 3 |
| CHD2 | ZC3H7B | 0.721646 | 3 | 0 | 3 |
| CHD2 | ANKRD13C | 0.718248 | 3 | 0 | 3 |
| CHD2 | ABCC9 | 0.71764 | 3 | 0 | 3 |
| CHD2 | LMAN1 | 0.71722 | 3 | 0 | 3 |
| CHD2 | GTF3C4 | 0.711159 | 4 | 0 | 3 |
| CHD2 | CXCL3 | 0.708793 | 3 | 0 | 3 |
| CHD2 | DNMBP | 0.698717 | 4 | 0 | 3 |
| CHD2 | FAM102B | 0.698579 | 3 | 0 | 3 |
| CHD2 | POGZ | 0.697345 | 3 | 0 | 3 |
For details and further investigation, click here
