| Full name: ras homolog family member Q | Alias Symbol: TC10 | ||
| Type: protein-coding gene | Cytoband: 2p21 | ||
| Entrez ID: 23433 | HGNC ID: HGNC:17736 | Ensembl Gene: ENSG00000119729 | OMIM ID: 605857 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RHOQ involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04910 | Insulin signaling pathway |
Expression of RHOQ:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RHOQ | 23433 | 212119_at | -0.2282 | 0.7646 | |
| GSE20347 | RHOQ | 23433 | 212119_at | 0.7184 | 0.0011 | |
| GSE23400 | RHOQ | 23433 | 212120_at | 0.2906 | 0.0351 | |
| GSE26886 | RHOQ | 23433 | 212119_at | 1.3168 | 0.0000 | |
| GSE29001 | RHOQ | 23433 | 212119_at | 0.5534 | 0.0773 | |
| GSE38129 | RHOQ | 23433 | 212119_at | 0.1646 | 0.5497 | |
| GSE45670 | RHOQ | 23433 | 212119_at | -0.5328 | 0.0846 | |
| GSE63941 | RHOQ | 23433 | 212119_at | -2.7258 | 0.0047 | |
| GSE77861 | RHOQ | 23433 | 212119_at | 1.3424 | 0.0003 | |
| GSE97050 | RHOQ | 23433 | A_32_P49844 | -0.1660 | 0.6074 | |
| SRP007169 | RHOQ | 23433 | RNAseq | 2.3464 | 0.0000 | |
| SRP008496 | RHOQ | 23433 | RNAseq | 2.5452 | 0.0000 | |
| SRP064894 | RHOQ | 23433 | RNAseq | 0.7240 | 0.0007 | |
| SRP133303 | RHOQ | 23433 | RNAseq | 0.7404 | 0.0025 | |
| SRP159526 | RHOQ | 23433 | RNAseq | 0.7981 | 0.0001 | |
| SRP193095 | RHOQ | 23433 | RNAseq | 0.8701 | 0.0000 | |
| SRP219564 | RHOQ | 23433 | RNAseq | 0.1488 | 0.8006 | |
| TCGA | RHOQ | 23433 | RNAseq | -0.0504 | 0.4281 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by RHOQ expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of RHOQ:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RHOQ | 23433 | 10 | 1 | 19 | |
| GSE20123 | RHOQ | 23433 | 9 | 1 | 20 | |
| GSE43470 | RHOQ | 23433 | 5 | 0 | 38 | |
| GSE46452 | RHOQ | 23433 | 1 | 4 | 54 | |
| GSE47630 | RHOQ | 23433 | 7 | 0 | 33 | |
| GSE54993 | RHOQ | 23433 | 0 | 5 | 65 | |
| GSE54994 | RHOQ | 23433 | 10 | 0 | 43 | |
| GSE60625 | RHOQ | 23433 | 0 | 3 | 8 | |
| GSE74703 | RHOQ | 23433 | 5 | 0 | 31 | |
| GSE74704 | RHOQ | 23433 | 9 | 1 | 10 | |
| TCGA | RHOQ | 23433 | 35 | 2 | 59 |
Total number of gains: 91; Total number of losses: 17; Total Number of normals: 380.
Somatic mutations of RHOQ:
Generating mutation plots.
Highly correlated genes for RHOQ:
Showing top 20/1108 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RHOQ | C12orf75 | 0.791358 | 3 | 0 | 3 |
| RHOQ | PLBD2 | 0.787438 | 3 | 0 | 3 |
| RHOQ | MMP1 | 0.769418 | 3 | 0 | 3 |
| RHOQ | CLIC4 | 0.754762 | 10 | 0 | 10 |
| RHOQ | HSPH1 | 0.747356 | 3 | 0 | 3 |
| RHOQ | LAMC1 | 0.743372 | 10 | 0 | 10 |
| RHOQ | MAP1B | 0.735116 | 11 | 0 | 9 |
| RHOQ | CLMP | 0.733136 | 4 | 0 | 4 |
| RHOQ | E2F6 | 0.72979 | 3 | 0 | 3 |
| RHOQ | FSTL1 | 0.729774 | 11 | 0 | 11 |
| RHOQ | TRIB1 | 0.724774 | 3 | 0 | 3 |
| RHOQ | GON4L | 0.720885 | 3 | 0 | 3 |
| RHOQ | PLEKHO1 | 0.720135 | 11 | 0 | 11 |
| RHOQ | NT5C3B | 0.718399 | 4 | 0 | 4 |
| RHOQ | SLC41A1 | 0.70601 | 4 | 0 | 4 |
| RHOQ | BLOC1S6 | 0.705388 | 3 | 0 | 3 |
| RHOQ | USP12 | 0.70447 | 9 | 0 | 8 |
| RHOQ | COL4A2 | 0.703484 | 11 | 0 | 9 |
| RHOQ | FERMT2 | 0.702831 | 11 | 0 | 11 |
| RHOQ | TMTC1 | 0.700891 | 6 | 0 | 6 |
For details and further investigation, click here
