| Full name: protein tyrosine phosphatase receptor type K | Alias Symbol: R-PTP-kappa | ||
| Type: protein-coding gene | Cytoband: 6q22.33 | ||
| Entrez ID: 5796 | HGNC ID: HGNC:9674 | Ensembl Gene: ENSG00000152894 | OMIM ID: 602545 |
| Drug and gene relationship at DGIdb | |||
Expression of PTPRK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTPRK | 5796 | 203038_at | 0.6929 | 0.0872 | |
| GSE20347 | PTPRK | 5796 | 203038_at | 1.1067 | 0.0000 | |
| GSE23400 | PTPRK | 5796 | 203038_at | 1.2518 | 0.0000 | |
| GSE26886 | PTPRK | 5796 | 203038_at | 2.6681 | 0.0000 | |
| GSE29001 | PTPRK | 5796 | 203038_at | 1.1639 | 0.0015 | |
| GSE38129 | PTPRK | 5796 | 203038_at | 0.8379 | 0.0000 | |
| GSE45670 | PTPRK | 5796 | 203038_at | 0.4788 | 0.0792 | |
| GSE53622 | PTPRK | 5796 | 50444 | 1.0149 | 0.0000 | |
| GSE53624 | PTPRK | 5796 | 74454 | 0.9077 | 0.0000 | |
| GSE63941 | PTPRK | 5796 | 203038_at | -1.4435 | 0.0167 | |
| GSE77861 | PTPRK | 5796 | 203038_at | 1.3864 | 0.0046 | |
| GSE97050 | PTPRK | 5796 | A_33_P3296482 | 0.7493 | 0.1181 | |
| SRP007169 | PTPRK | 5796 | RNAseq | 1.8735 | 0.0000 | |
| SRP008496 | PTPRK | 5796 | RNAseq | 2.0866 | 0.0000 | |
| SRP064894 | PTPRK | 5796 | RNAseq | 1.0609 | 0.0000 | |
| SRP133303 | PTPRK | 5796 | RNAseq | 1.0914 | 0.0000 | |
| SRP159526 | PTPRK | 5796 | RNAseq | 0.8374 | 0.0074 | |
| SRP193095 | PTPRK | 5796 | RNAseq | 0.9481 | 0.0000 | |
| SRP219564 | PTPRK | 5796 | RNAseq | 0.7339 | 0.1864 | |
| TCGA | PTPRK | 5796 | RNAseq | -0.0587 | 0.2896 |
Upregulated datasets: 10; Downregulated datasets: 1.
Survival by PTPRK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTPRK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTPRK | 5796 | 1 | 4 | 25 | |
| GSE20123 | PTPRK | 5796 | 2 | 3 | 25 | |
| GSE43470 | PTPRK | 5796 | 5 | 0 | 38 | |
| GSE46452 | PTPRK | 5796 | 2 | 11 | 46 | |
| GSE47630 | PTPRK | 5796 | 9 | 4 | 27 | |
| GSE54993 | PTPRK | 5796 | 3 | 3 | 64 | |
| GSE54994 | PTPRK | 5796 | 9 | 7 | 37 | |
| GSE60625 | PTPRK | 5796 | 0 | 1 | 10 | |
| GSE74703 | PTPRK | 5796 | 4 | 0 | 32 | |
| GSE74704 | PTPRK | 5796 | 0 | 1 | 19 | |
| TCGA | PTPRK | 5796 | 10 | 19 | 67 |
Total number of gains: 45; Total number of losses: 53; Total Number of normals: 390.
Somatic mutations of PTPRK:
Generating mutation plots.
Highly correlated genes for PTPRK:
Showing top 20/1679 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTPRK | CBLB | 0.769144 | 10 | 0 | 10 |
| PTPRK | ZNF574 | 0.759852 | 3 | 0 | 3 |
| PTPRK | PDIA5 | 0.758871 | 3 | 0 | 3 |
| PTPRK | CBX3 | 0.7563 | 10 | 0 | 10 |
| PTPRK | TMEM184B | 0.754882 | 10 | 0 | 10 |
| PTPRK | ADAR | 0.752834 | 10 | 0 | 10 |
| PTPRK | FNDC3B | 0.752422 | 13 | 0 | 11 |
| PTPRK | SLC25A32 | 0.751781 | 11 | 0 | 11 |
| PTPRK | STK3 | 0.748393 | 10 | 0 | 10 |
| PTPRK | CLEC2B | 0.748062 | 3 | 0 | 3 |
| PTPRK | PYCR2 | 0.741588 | 3 | 0 | 3 |
| PTPRK | PTK2 | 0.741143 | 12 | 0 | 11 |
| PTPRK | WDR54 | 0.740835 | 6 | 0 | 6 |
| PTPRK | PLXNA1 | 0.739404 | 11 | 0 | 11 |
| PTPRK | TMEM263 | 0.738505 | 7 | 0 | 7 |
| PTPRK | MINPP1 | 0.7373 | 12 | 0 | 12 |
| PTPRK | MORC2 | 0.736208 | 10 | 0 | 9 |
| PTPRK | MFAP2 | 0.734397 | 11 | 0 | 11 |
| PTPRK | DESI2 | 0.73364 | 10 | 0 | 10 |
| PTPRK | RAB34 | 0.732475 | 3 | 0 | 3 |
For details and further investigation, click here
