| Full name: sodium voltage-gated channel alpha subunit 11 | Alias Symbol: Nav1.9|NaN|SNS-2 | ||
| Type: protein-coding gene | Cytoband: 3p22.2 | ||
| Entrez ID: 11280 | HGNC ID: HGNC:10583 | Ensembl Gene: ENSG00000168356 | OMIM ID: 604385 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SCN11A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCN11A | 11280 | 210853_at | 0.2607 | 0.5873 | |
| GSE20347 | SCN11A | 11280 | 210853_at | 0.0418 | 0.6368 | |
| GSE23400 | SCN11A | 11280 | 210853_at | -0.0308 | 0.3330 | |
| GSE26886 | SCN11A | 11280 | 210853_at | -0.0267 | 0.7917 | |
| GSE29001 | SCN11A | 11280 | 210853_at | 0.0458 | 0.8153 | |
| GSE38129 | SCN11A | 11280 | 210853_at | -0.0519 | 0.5123 | |
| GSE45670 | SCN11A | 11280 | 210853_at | -0.0352 | 0.8187 | |
| GSE63941 | SCN11A | 11280 | 210853_at | -0.0682 | 0.6154 | |
| GSE77861 | SCN11A | 11280 | 210853_at | 0.0477 | 0.5639 | |
| SRP133303 | SCN11A | 11280 | RNAseq | -0.6037 | 0.2009 | |
| TCGA | SCN11A | 11280 | RNAseq | -2.1061 | 0.0016 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SCN11A expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SCN11A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCN11A | 11280 | 0 | 19 | 11 | |
| GSE20123 | SCN11A | 11280 | 0 | 19 | 11 | |
| GSE43470 | SCN11A | 11280 | 0 | 20 | 23 | |
| GSE46452 | SCN11A | 11280 | 2 | 17 | 40 | |
| GSE47630 | SCN11A | 11280 | 1 | 25 | 14 | |
| GSE54993 | SCN11A | 11280 | 7 | 2 | 61 | |
| GSE54994 | SCN11A | 11280 | 0 | 34 | 19 | |
| GSE60625 | SCN11A | 11280 | 5 | 0 | 6 | |
| GSE74703 | SCN11A | 11280 | 0 | 16 | 20 | |
| GSE74704 | SCN11A | 11280 | 0 | 13 | 7 | |
| TCGA | SCN11A | 11280 | 1 | 71 | 24 |
Total number of gains: 16; Total number of losses: 236; Total Number of normals: 236.
Somatic mutations of SCN11A:
Generating mutation plots.
Highly correlated genes for SCN11A:
Showing top 20/462 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCN11A | FOXN3-AS2 | 0.761378 | 4 | 0 | 4 |
| SCN11A | RECK | 0.741031 | 3 | 0 | 3 |
| SCN11A | SLC30A3 | 0.733457 | 4 | 0 | 4 |
| SCN11A | PTPRJ | 0.702446 | 4 | 0 | 4 |
| SCN11A | WRNIP1 | 0.702126 | 4 | 0 | 4 |
| SCN11A | MYO7A | 0.702085 | 3 | 0 | 3 |
| SCN11A | STX1A | 0.700562 | 3 | 0 | 3 |
| SCN11A | ZP2 | 0.697711 | 3 | 0 | 3 |
| SCN11A | TRPM3 | 0.693772 | 4 | 0 | 4 |
| SCN11A | SLC5A4 | 0.692889 | 4 | 0 | 4 |
| SCN11A | KCNJ10 | 0.685984 | 4 | 0 | 4 |
| SCN11A | PEX5L | 0.684132 | 3 | 0 | 3 |
| SCN11A | ZNF611 | 0.682332 | 3 | 0 | 3 |
| SCN11A | OR10H3 | 0.67932 | 4 | 0 | 4 |
| SCN11A | RIT2 | 0.677547 | 4 | 0 | 3 |
| SCN11A | MTAP | 0.676137 | 4 | 0 | 4 |
| SCN11A | DAB1 | 0.674448 | 4 | 0 | 4 |
| SCN11A | ZNF160 | 0.673397 | 3 | 0 | 3 |
| SCN11A | ZMIZ2 | 0.670042 | 4 | 0 | 3 |
| SCN11A | AMELY | 0.667524 | 3 | 0 | 3 |
For details and further investigation, click here
