| Full name: syntaxin 1A | Alias Symbol: HPC-1|p35-1 | ||
| Type: protein-coding gene | Cytoband: 7q11.23 | ||
| Entrez ID: 6804 | HGNC ID: HGNC:11433 | Ensembl Gene: ENSG00000106089 | OMIM ID: 186590 |
| Drug and gene relationship at DGIdb | |||
STX1A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05031 | Amphetamine addiction |
Expression of STX1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STX1A | 6804 | 204729_s_at | 1.1224 | 0.0770 | |
| GSE20347 | STX1A | 6804 | 204729_s_at | 0.3847 | 0.0001 | |
| GSE23400 | STX1A | 6804 | 204729_s_at | 0.2446 | 0.0002 | |
| GSE26886 | STX1A | 6804 | 204729_s_at | 0.6305 | 0.0001 | |
| GSE29001 | STX1A | 6804 | 204729_s_at | 0.2821 | 0.1259 | |
| GSE38129 | STX1A | 6804 | 204729_s_at | 0.3703 | 0.0002 | |
| GSE45670 | STX1A | 6804 | 204729_s_at | 0.4709 | 0.0015 | |
| GSE53622 | STX1A | 6804 | 96472 | -0.2645 | 0.1444 | |
| GSE53624 | STX1A | 6804 | 96472 | -0.0895 | 0.4884 | |
| GSE63941 | STX1A | 6804 | 204729_s_at | 0.0181 | 0.9549 | |
| GSE77861 | STX1A | 6804 | 204729_s_at | 0.3666 | 0.0901 | |
| GSE97050 | STX1A | 6804 | A_23_P168556 | 0.0307 | 0.9611 | |
| SRP007169 | STX1A | 6804 | RNAseq | 5.0293 | 0.0006 | |
| SRP064894 | STX1A | 6804 | RNAseq | 2.0659 | 0.0000 | |
| SRP133303 | STX1A | 6804 | RNAseq | 2.0896 | 0.0000 | |
| SRP159526 | STX1A | 6804 | RNAseq | 1.9045 | 0.0001 | |
| SRP193095 | STX1A | 6804 | RNAseq | 2.0125 | 0.0000 | |
| SRP219564 | STX1A | 6804 | RNAseq | 2.2060 | 0.0000 | |
| TCGA | STX1A | 6804 | RNAseq | 0.2729 | 0.0300 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by STX1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STX1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STX1A | 6804 | 14 | 1 | 15 | |
| GSE20123 | STX1A | 6804 | 14 | 1 | 15 | |
| GSE43470 | STX1A | 6804 | 3 | 2 | 38 | |
| GSE46452 | STX1A | 6804 | 12 | 0 | 47 | |
| GSE47630 | STX1A | 6804 | 7 | 2 | 31 | |
| GSE54993 | STX1A | 6804 | 2 | 7 | 61 | |
| GSE54994 | STX1A | 6804 | 14 | 3 | 36 | |
| GSE60625 | STX1A | 6804 | 0 | 0 | 11 | |
| GSE74703 | STX1A | 6804 | 3 | 1 | 32 | |
| GSE74704 | STX1A | 6804 | 8 | 1 | 11 | |
| TCGA | STX1A | 6804 | 45 | 7 | 44 |
Total number of gains: 122; Total number of losses: 25; Total Number of normals: 341.
Somatic mutations of STX1A:
Generating mutation plots.
Highly correlated genes for STX1A:
Showing top 20/753 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STX1A | TP53I13 | 0.751437 | 3 | 0 | 3 |
| STX1A | SLC39A3 | 0.742863 | 3 | 0 | 3 |
| STX1A | GATAD2B | 0.740551 | 3 | 0 | 3 |
| STX1A | ZDHHC8 | 0.738234 | 3 | 0 | 3 |
| STX1A | FBLIM1 | 0.73623 | 4 | 0 | 4 |
| STX1A | HAGLROS | 0.73307 | 3 | 0 | 3 |
| STX1A | CNTROB | 0.7316 | 3 | 0 | 3 |
| STX1A | KCTD17 | 0.724161 | 3 | 0 | 3 |
| STX1A | PDE7A | 0.719612 | 3 | 0 | 3 |
| STX1A | RTKN | 0.714375 | 4 | 0 | 4 |
| STX1A | LDB1 | 0.709308 | 5 | 0 | 5 |
| STX1A | SCN11A | 0.700562 | 3 | 0 | 3 |
| STX1A | TAPBP | 0.699202 | 4 | 0 | 4 |
| STX1A | PRAM1 | 0.694999 | 3 | 0 | 3 |
| STX1A | CDC42EP2 | 0.694076 | 3 | 0 | 3 |
| STX1A | HSPH1 | 0.690841 | 5 | 0 | 4 |
| STX1A | SYDE1 | 0.687769 | 4 | 0 | 4 |
| STX1A | CPNE2 | 0.683984 | 3 | 0 | 3 |
| STX1A | CLEC12B | 0.680894 | 3 | 0 | 3 |
| STX1A | SLC2A3 | 0.679085 | 3 | 0 | 3 |
For details and further investigation, click here
