| Full name: myosin VIIA | Alias Symbol: NSRD2 | ||
| Type: protein-coding gene | Cytoband: 11q13.5 | ||
| Entrez ID: 4647 | HGNC ID: HGNC:7606 | Ensembl Gene: ENSG00000137474 | OMIM ID: 276903 |
| Drug and gene relationship at DGIdb | |||
Expression of MYO7A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYO7A | 4647 | 208189_s_at | 0.6802 | 0.3168 | |
| GSE20347 | MYO7A | 4647 | 211104_s_at | -0.1447 | 0.0209 | |
| GSE23400 | MYO7A | 4647 | 208189_s_at | 0.0814 | 0.1046 | |
| GSE26886 | MYO7A | 4647 | 208189_s_at | 0.2065 | 0.2213 | |
| GSE29001 | MYO7A | 4647 | 208189_s_at | -0.0636 | 0.7030 | |
| GSE38129 | MYO7A | 4647 | 211104_s_at | -0.1412 | 0.0086 | |
| GSE45670 | MYO7A | 4647 | 33197_at | 0.3438 | 0.0611 | |
| GSE53622 | MYO7A | 4647 | 64697 | -0.2126 | 0.1656 | |
| GSE53624 | MYO7A | 4647 | 5178 | 1.3511 | 0.0000 | |
| GSE63941 | MYO7A | 4647 | 208189_s_at | 0.2808 | 0.2851 | |
| GSE77861 | MYO7A | 4647 | 208189_s_at | 0.0584 | 0.6678 | |
| GSE97050 | MYO7A | 4647 | A_23_P422350 | 0.5337 | 0.2571 | |
| SRP007169 | MYO7A | 4647 | RNAseq | 2.6163 | 0.0022 | |
| SRP064894 | MYO7A | 4647 | RNAseq | 1.0558 | 0.0000 | |
| SRP133303 | MYO7A | 4647 | RNAseq | 0.8667 | 0.0060 | |
| SRP159526 | MYO7A | 4647 | RNAseq | 0.5219 | 0.1995 | |
| SRP193095 | MYO7A | 4647 | RNAseq | 0.8165 | 0.0055 | |
| SRP219564 | MYO7A | 4647 | RNAseq | 1.4607 | 0.0072 | |
| TCGA | MYO7A | 4647 | RNAseq | 0.1587 | 0.3772 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by MYO7A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYO7A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYO7A | 4647 | 5 | 9 | 16 | |
| GSE20123 | MYO7A | 4647 | 5 | 8 | 17 | |
| GSE43470 | MYO7A | 4647 | 3 | 3 | 37 | |
| GSE46452 | MYO7A | 4647 | 8 | 21 | 30 | |
| GSE47630 | MYO7A | 4647 | 5 | 16 | 19 | |
| GSE54993 | MYO7A | 4647 | 8 | 2 | 60 | |
| GSE54994 | MYO7A | 4647 | 7 | 17 | 29 | |
| GSE60625 | MYO7A | 4647 | 4 | 3 | 4 | |
| GSE74703 | MYO7A | 4647 | 2 | 2 | 32 | |
| GSE74704 | MYO7A | 4647 | 3 | 4 | 13 | |
| TCGA | MYO7A | 4647 | 20 | 31 | 45 |
Total number of gains: 70; Total number of losses: 116; Total Number of normals: 302.
Somatic mutations of MYO7A:
Generating mutation plots.
Highly correlated genes for MYO7A:
Showing top 20/174 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYO7A | KDM6B | 0.772882 | 3 | 0 | 3 |
| MYO7A | POU5F1B | 0.745341 | 3 | 0 | 3 |
| MYO7A | SCN11A | 0.702085 | 3 | 0 | 3 |
| MYO7A | TMEM150B | 0.681194 | 3 | 0 | 3 |
| MYO7A | KLHDC7B | 0.668761 | 5 | 0 | 4 |
| MYO7A | TBR1 | 0.648263 | 3 | 0 | 3 |
| MYO7A | CCR5 | 0.647906 | 4 | 0 | 3 |
| MYO7A | UTP23 | 0.647802 | 3 | 0 | 3 |
| MYO7A | ANKRD10-IT1 | 0.644403 | 3 | 0 | 3 |
| MYO7A | C6 | 0.643868 | 3 | 0 | 3 |
| MYO7A | RASAL3 | 0.641915 | 3 | 0 | 3 |
| MYO7A | TNK2 | 0.640416 | 3 | 0 | 3 |
| MYO7A | LILRB2 | 0.640371 | 3 | 0 | 3 |
| MYO7A | TBX15 | 0.635864 | 3 | 0 | 3 |
| MYO7A | PADI2 | 0.633528 | 4 | 0 | 3 |
| MYO7A | CASP5 | 0.63177 | 3 | 0 | 3 |
| MYO7A | PDCD1LG2 | 0.629754 | 3 | 0 | 3 |
| MYO7A | GHRH | 0.627256 | 3 | 0 | 3 |
| MYO7A | NLRC5 | 0.624005 | 5 | 0 | 3 |
| MYO7A | SIPA1L3 | 0.619723 | 3 | 0 | 3 |
For details and further investigation, click here
