| Full name: SCO cytochrome c oxidase assembly protein 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 6341 | HGNC ID: HGNC:10603 | Ensembl Gene: ENSG00000133028 | OMIM ID: 603644 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SCO1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCO1 | 6341 | 223221_at | 0.2465 | 0.4883 | |
| GSE26886 | SCO1 | 6341 | 223221_at | -0.1674 | 0.4482 | |
| GSE45670 | SCO1 | 6341 | 223221_at | 0.2139 | 0.2037 | |
| GSE53622 | SCO1 | 6341 | 129735 | 0.3258 | 0.0000 | |
| GSE53624 | SCO1 | 6341 | 129735 | 0.2739 | 0.0017 | |
| GSE63941 | SCO1 | 6341 | 223221_at | 0.1764 | 0.7209 | |
| GSE77861 | SCO1 | 6341 | 223221_at | 0.1324 | 0.6328 | |
| GSE97050 | SCO1 | 6341 | A_23_P15466 | 0.1823 | 0.4039 | |
| SRP007169 | SCO1 | 6341 | RNAseq | 0.7193 | 0.0671 | |
| SRP008496 | SCO1 | 6341 | RNAseq | 0.6617 | 0.0198 | |
| SRP064894 | SCO1 | 6341 | RNAseq | 0.5256 | 0.0038 | |
| SRP133303 | SCO1 | 6341 | RNAseq | 0.1954 | 0.1038 | |
| SRP159526 | SCO1 | 6341 | RNAseq | 0.0398 | 0.8662 | |
| SRP193095 | SCO1 | 6341 | RNAseq | -0.0367 | 0.5652 | |
| SRP219564 | SCO1 | 6341 | RNAseq | 0.4794 | 0.2760 | |
| TCGA | SCO1 | 6341 | RNAseq | -0.0198 | 0.7258 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SCO1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCO1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCO1 | 6341 | 3 | 4 | 23 | |
| GSE20123 | SCO1 | 6341 | 3 | 5 | 22 | |
| GSE43470 | SCO1 | 6341 | 2 | 5 | 36 | |
| GSE46452 | SCO1 | 6341 | 34 | 1 | 24 | |
| GSE47630 | SCO1 | 6341 | 7 | 1 | 32 | |
| GSE54993 | SCO1 | 6341 | 3 | 4 | 63 | |
| GSE54994 | SCO1 | 6341 | 5 | 7 | 41 | |
| GSE60625 | SCO1 | 6341 | 4 | 0 | 7 | |
| GSE74703 | SCO1 | 6341 | 2 | 3 | 31 | |
| GSE74704 | SCO1 | 6341 | 2 | 2 | 16 | |
| TCGA | SCO1 | 6341 | 18 | 20 | 58 |
Total number of gains: 83; Total number of losses: 52; Total Number of normals: 353.
Somatic mutations of SCO1:
Generating mutation plots.
Highly correlated genes for SCO1:
Showing top 20/745 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCO1 | CDK5RAP1 | 0.804151 | 3 | 0 | 3 |
| SCO1 | AGTPBP1 | 0.758885 | 3 | 0 | 3 |
| SCO1 | SLC7A6OS | 0.758554 | 3 | 0 | 3 |
| SCO1 | RPS21 | 0.757768 | 3 | 0 | 3 |
| SCO1 | WDR61 | 0.752917 | 4 | 0 | 4 |
| SCO1 | MFN1 | 0.741843 | 3 | 0 | 3 |
| SCO1 | JTB | 0.737482 | 3 | 0 | 3 |
| SCO1 | RBM22 | 0.736284 | 3 | 0 | 3 |
| SCO1 | HNRNPA0 | 0.732703 | 3 | 0 | 3 |
| SCO1 | ZNF627 | 0.729505 | 3 | 0 | 3 |
| SCO1 | RPL19 | 0.725375 | 3 | 0 | 3 |
| SCO1 | DDX1 | 0.72497 | 3 | 0 | 3 |
| SCO1 | TRUB1 | 0.724782 | 3 | 0 | 3 |
| SCO1 | NCKAP1 | 0.722774 | 3 | 0 | 3 |
| SCO1 | PEMT | 0.720099 | 4 | 0 | 4 |
| SCO1 | MYNN | 0.719883 | 3 | 0 | 3 |
| SCO1 | ALG14 | 0.71604 | 3 | 0 | 3 |
| SCO1 | PI4K2B | 0.715087 | 3 | 0 | 3 |
| SCO1 | ZFP90 | 0.71329 | 3 | 0 | 3 |
| SCO1 | DDX54 | 0.709623 | 3 | 0 | 3 |
For details and further investigation, click here
