| Full name: DEAD-box helicase 1 | Alias Symbol: DBP-RB | ||
| Type: protein-coding gene | Cytoband: 2p24.3 | ||
| Entrez ID: 1653 | HGNC ID: HGNC:2734 | Ensembl Gene: ENSG00000079785 | OMIM ID: 601257 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DDX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX1 | 1653 | 201241_at | -0.2001 | 0.7133 | |
| GSE20347 | DDX1 | 1653 | 201241_at | -0.0138 | 0.9368 | |
| GSE23400 | DDX1 | 1653 | 201241_at | 0.1675 | 0.0054 | |
| GSE26886 | DDX1 | 1653 | 201241_at | -0.2566 | 0.2517 | |
| GSE29001 | DDX1 | 1653 | 201241_at | -0.0601 | 0.7973 | |
| GSE38129 | DDX1 | 1653 | 201241_at | 0.0377 | 0.7697 | |
| GSE45670 | DDX1 | 1653 | 201241_at | 0.0509 | 0.6558 | |
| GSE53622 | DDX1 | 1653 | 108610 | -0.1943 | 0.0010 | |
| GSE53624 | DDX1 | 1653 | 108610 | 0.0633 | 0.2593 | |
| GSE63941 | DDX1 | 1653 | 201241_at | -0.0198 | 0.9646 | |
| GSE77861 | DDX1 | 1653 | 201241_at | -0.3541 | 0.5081 | |
| GSE97050 | DDX1 | 1653 | A_23_P108554 | 0.0023 | 0.9949 | |
| SRP007169 | DDX1 | 1653 | RNAseq | 0.0257 | 0.9328 | |
| SRP008496 | DDX1 | 1653 | RNAseq | 0.2979 | 0.2219 | |
| SRP064894 | DDX1 | 1653 | RNAseq | -0.0790 | 0.5806 | |
| SRP133303 | DDX1 | 1653 | RNAseq | 0.0547 | 0.6629 | |
| SRP159526 | DDX1 | 1653 | RNAseq | 0.1449 | 0.4764 | |
| SRP193095 | DDX1 | 1653 | RNAseq | -0.1850 | 0.1374 | |
| SRP219564 | DDX1 | 1653 | RNAseq | 0.0478 | 0.8900 | |
| TCGA | DDX1 | 1653 | RNAseq | 0.0021 | 0.9616 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DDX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX1 | 1653 | 9 | 2 | 19 | |
| GSE20123 | DDX1 | 1653 | 9 | 2 | 19 | |
| GSE43470 | DDX1 | 1653 | 2 | 0 | 41 | |
| GSE46452 | DDX1 | 1653 | 3 | 4 | 52 | |
| GSE47630 | DDX1 | 1653 | 7 | 0 | 33 | |
| GSE54993 | DDX1 | 1653 | 0 | 7 | 63 | |
| GSE54994 | DDX1 | 1653 | 11 | 0 | 42 | |
| GSE60625 | DDX1 | 1653 | 0 | 3 | 8 | |
| GSE74703 | DDX1 | 1653 | 2 | 0 | 34 | |
| GSE74704 | DDX1 | 1653 | 8 | 2 | 10 | |
| TCGA | DDX1 | 1653 | 33 | 5 | 58 |
Total number of gains: 84; Total number of losses: 25; Total Number of normals: 379.
Somatic mutations of DDX1:
Generating mutation plots.
Highly correlated genes for DDX1:
Showing top 20/335 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX1 | LRRC28 | 0.79235 | 3 | 0 | 3 |
| DDX1 | FAHD1 | 0.754943 | 3 | 0 | 3 |
| DDX1 | SCO1 | 0.72497 | 3 | 0 | 3 |
| DDX1 | TPM4 | 0.718278 | 3 | 0 | 3 |
| DDX1 | NDUFA10 | 0.715911 | 4 | 0 | 4 |
| DDX1 | SDHD | 0.712305 | 5 | 0 | 5 |
| DDX1 | TTI2 | 0.707873 | 3 | 0 | 3 |
| DDX1 | USP32 | 0.70666 | 4 | 0 | 4 |
| DDX1 | COX7B | 0.694132 | 4 | 0 | 3 |
| DDX1 | IDH3A | 0.693952 | 4 | 0 | 3 |
| DDX1 | GOT1 | 0.678634 | 4 | 0 | 4 |
| DDX1 | RRAD | 0.677763 | 3 | 0 | 3 |
| DDX1 | STT3B | 0.676994 | 3 | 0 | 3 |
| DDX1 | ALAS1 | 0.676816 | 5 | 0 | 4 |
| DDX1 | EAPP | 0.670175 | 3 | 0 | 3 |
| DDX1 | DTD1 | 0.669002 | 4 | 0 | 3 |
| DDX1 | IWS1 | 0.664549 | 3 | 0 | 3 |
| DDX1 | ZCCHC9 | 0.663153 | 4 | 0 | 3 |
| DDX1 | PGM1 | 0.662919 | 4 | 0 | 3 |
| DDX1 | ACER3 | 0.662602 | 3 | 0 | 3 |
For details and further investigation, click here
