| Full name: TruB pseudouridine synthase family member 1 | Alias Symbol: PUS4 | ||
| Type: protein-coding gene | Cytoband: 10q25.3 | ||
| Entrez ID: 142940 | HGNC ID: HGNC:16060 | Ensembl Gene: ENSG00000165832 | OMIM ID: 610726 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TRUB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRUB1 | 142940 | 226339_at | 0.6102 | 0.1500 | |
| GSE26886 | TRUB1 | 142940 | 226339_at | 0.4112 | 0.1780 | |
| GSE45670 | TRUB1 | 142940 | 226339_at | 0.4399 | 0.0018 | |
| GSE53622 | TRUB1 | 142940 | 52485 | 0.4267 | 0.0007 | |
| GSE53624 | TRUB1 | 142940 | 52485 | 0.4655 | 0.0000 | |
| GSE63941 | TRUB1 | 142940 | 226339_at | -0.0089 | 0.9808 | |
| GSE77861 | TRUB1 | 142940 | 226339_at | 0.3350 | 0.3606 | |
| GSE97050 | TRUB1 | 142940 | A_23_P63908 | 0.0714 | 0.7344 | |
| SRP007169 | TRUB1 | 142940 | RNAseq | 1.1304 | 0.0493 | |
| SRP008496 | TRUB1 | 142940 | RNAseq | 0.8352 | 0.0393 | |
| SRP064894 | TRUB1 | 142940 | RNAseq | 0.0006 | 0.9984 | |
| SRP133303 | TRUB1 | 142940 | RNAseq | 0.7625 | 0.0001 | |
| SRP159526 | TRUB1 | 142940 | RNAseq | 0.2993 | 0.4093 | |
| SRP193095 | TRUB1 | 142940 | RNAseq | 0.0869 | 0.4676 | |
| SRP219564 | TRUB1 | 142940 | RNAseq | 0.1448 | 0.6363 | |
| TCGA | TRUB1 | 142940 | RNAseq | 0.0370 | 0.4781 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TRUB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRUB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRUB1 | 142940 | 1 | 8 | 21 | |
| GSE20123 | TRUB1 | 142940 | 1 | 7 | 22 | |
| GSE43470 | TRUB1 | 142940 | 0 | 9 | 34 | |
| GSE46452 | TRUB1 | 142940 | 0 | 11 | 48 | |
| GSE47630 | TRUB1 | 142940 | 2 | 14 | 24 | |
| GSE54993 | TRUB1 | 142940 | 8 | 0 | 62 | |
| GSE54994 | TRUB1 | 142940 | 1 | 9 | 43 | |
| GSE60625 | TRUB1 | 142940 | 0 | 0 | 11 | |
| GSE74703 | TRUB1 | 142940 | 0 | 6 | 30 | |
| GSE74704 | TRUB1 | 142940 | 1 | 3 | 16 | |
| TCGA | TRUB1 | 142940 | 4 | 28 | 64 |
Total number of gains: 18; Total number of losses: 95; Total Number of normals: 375.
Somatic mutations of TRUB1:
Generating mutation plots.
Highly correlated genes for TRUB1:
Showing top 20/930 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRUB1 | RBM12 | 0.83822 | 3 | 0 | 3 |
| TRUB1 | CENPBD1 | 0.819607 | 3 | 0 | 3 |
| TRUB1 | LRRC42 | 0.810972 | 3 | 0 | 3 |
| TRUB1 | DLG5 | 0.804784 | 3 | 0 | 3 |
| TRUB1 | GPD2 | 0.794 | 3 | 0 | 3 |
| TRUB1 | DNAJC9 | 0.791197 | 4 | 0 | 4 |
| TRUB1 | NCBP1 | 0.784724 | 3 | 0 | 3 |
| TRUB1 | DEK | 0.782381 | 3 | 0 | 3 |
| TRUB1 | MRPL11 | 0.77928 | 3 | 0 | 3 |
| TRUB1 | SIKE1 | 0.779181 | 3 | 0 | 3 |
| TRUB1 | RCN2 | 0.773651 | 4 | 0 | 4 |
| TRUB1 | MRTO4 | 0.76963 | 3 | 0 | 3 |
| TRUB1 | ALG1 | 0.767509 | 3 | 0 | 3 |
| TRUB1 | FARS2 | 0.766213 | 3 | 0 | 3 |
| TRUB1 | NIF3L1 | 0.761775 | 4 | 0 | 3 |
| TRUB1 | ANAPC4 | 0.761183 | 3 | 0 | 3 |
| TRUB1 | FBXW8 | 0.756488 | 3 | 0 | 3 |
| TRUB1 | NSMCE4A | 0.752893 | 3 | 0 | 3 |
| TRUB1 | NCAPD3 | 0.75074 | 4 | 0 | 3 |
| TRUB1 | C1QBP | 0.746078 | 4 | 0 | 4 |
For details and further investigation, click here
