| Full name: mitofusin 1 | Alias Symbol: FLJ20693 | ||
| Type: protein-coding gene | Cytoband: 3q26.33 | ||
| Entrez ID: 55669 | HGNC ID: HGNC:18262 | Ensembl Gene: ENSG00000171109 | OMIM ID: 608506 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MFN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MFN1 | 55669 | 207098_s_at | 0.1320 | 0.8544 | |
| GSE20347 | MFN1 | 55669 | 207098_s_at | 0.3012 | 0.0402 | |
| GSE23400 | MFN1 | 55669 | 217043_s_at | 0.2714 | 0.0018 | |
| GSE26886 | MFN1 | 55669 | 207098_s_at | -0.0730 | 0.8174 | |
| GSE29001 | MFN1 | 55669 | 207098_s_at | -0.0456 | 0.9133 | |
| GSE38129 | MFN1 | 55669 | 207098_s_at | 0.5275 | 0.0028 | |
| GSE45670 | MFN1 | 55669 | 207098_s_at | 0.2900 | 0.1211 | |
| GSE53622 | MFN1 | 55669 | 93118 | 0.3306 | 0.0000 | |
| GSE53624 | MFN1 | 55669 | 93118 | 0.2909 | 0.0000 | |
| GSE63941 | MFN1 | 55669 | 217043_s_at | 1.0522 | 0.0339 | |
| GSE77861 | MFN1 | 55669 | 207098_s_at | 0.1089 | 0.7542 | |
| GSE97050 | MFN1 | 55669 | A_23_P80648 | 0.1592 | 0.4601 | |
| SRP007169 | MFN1 | 55669 | RNAseq | 1.3118 | 0.0475 | |
| SRP008496 | MFN1 | 55669 | RNAseq | 0.0412 | 0.7649 | |
| SRP064894 | MFN1 | 55669 | RNAseq | -0.0698 | 0.7271 | |
| SRP133303 | MFN1 | 55669 | RNAseq | 0.5033 | 0.0038 | |
| SRP159526 | MFN1 | 55669 | RNAseq | 0.4915 | 0.1692 | |
| SRP193095 | MFN1 | 55669 | RNAseq | 0.0592 | 0.5856 | |
| SRP219564 | MFN1 | 55669 | RNAseq | -0.3918 | 0.2886 | |
| TCGA | MFN1 | 55669 | RNAseq | 0.0537 | 0.2612 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by MFN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MFN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MFN1 | 55669 | 25 | 0 | 5 | |
| GSE20123 | MFN1 | 55669 | 25 | 0 | 5 | |
| GSE43470 | MFN1 | 55669 | 24 | 0 | 19 | |
| GSE46452 | MFN1 | 55669 | 19 | 1 | 39 | |
| GSE47630 | MFN1 | 55669 | 27 | 2 | 11 | |
| GSE54993 | MFN1 | 55669 | 1 | 18 | 51 | |
| GSE54994 | MFN1 | 55669 | 41 | 0 | 12 | |
| GSE60625 | MFN1 | 55669 | 0 | 6 | 5 | |
| GSE74703 | MFN1 | 55669 | 20 | 0 | 16 | |
| GSE74704 | MFN1 | 55669 | 16 | 0 | 4 | |
| TCGA | MFN1 | 55669 | 78 | 0 | 18 |
Total number of gains: 276; Total number of losses: 27; Total Number of normals: 185.
Somatic mutations of MFN1:
Generating mutation plots.
Highly correlated genes for MFN1:
Showing top 20/730 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MFN1 | ANKRD13C | 0.836561 | 3 | 0 | 3 |
| MFN1 | TMEM117 | 0.81253 | 3 | 0 | 3 |
| MFN1 | UBE2L3 | 0.805798 | 3 | 0 | 3 |
| MFN1 | PPWD1 | 0.780765 | 3 | 0 | 3 |
| MFN1 | HSD17B12 | 0.779734 | 3 | 0 | 3 |
| MFN1 | NHSL1 | 0.777306 | 3 | 0 | 3 |
| MFN1 | TBC1D2 | 0.774171 | 3 | 0 | 3 |
| MFN1 | ARL6 | 0.774164 | 3 | 0 | 3 |
| MFN1 | PIBF1 | 0.769594 | 3 | 0 | 3 |
| MFN1 | ACBD5 | 0.769074 | 3 | 0 | 3 |
| MFN1 | MED4 | 0.763609 | 4 | 0 | 4 |
| MFN1 | TBC1D15 | 0.75773 | 3 | 0 | 3 |
| MFN1 | PIK3C3 | 0.750915 | 3 | 0 | 3 |
| MFN1 | LIPT1 | 0.750879 | 4 | 0 | 3 |
| MFN1 | SPTY2D1 | 0.744217 | 3 | 0 | 3 |
| MFN1 | SCO1 | 0.741843 | 3 | 0 | 3 |
| MFN1 | REST | 0.741113 | 3 | 0 | 3 |
| MFN1 | TMEM60 | 0.739124 | 3 | 0 | 3 |
| MFN1 | XBP1 | 0.737544 | 3 | 0 | 3 |
| MFN1 | IWS1 | 0.736386 | 3 | 0 | 3 |
For details and further investigation, click here
