| Full name: DEAD-box helicase 54 | Alias Symbol: MGC2835|APR-5|DP97 | ||
| Type: protein-coding gene | Cytoband: 12q24.13 | ||
| Entrez ID: 79039 | HGNC ID: HGNC:20084 | Ensembl Gene: ENSG00000123064 | OMIM ID: 611665 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DDX54:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX54 | 79039 | 219111_s_at | 0.5131 | 0.1634 | |
| GSE20347 | DDX54 | 79039 | 219111_s_at | 0.3958 | 0.0013 | |
| GSE23400 | DDX54 | 79039 | 219111_s_at | 0.2724 | 0.0000 | |
| GSE26886 | DDX54 | 79039 | 219111_s_at | 1.1085 | 0.0000 | |
| GSE29001 | DDX54 | 79039 | 219111_s_at | 0.4358 | 0.0163 | |
| GSE38129 | DDX54 | 79039 | 219111_s_at | 0.4634 | 0.0001 | |
| GSE45670 | DDX54 | 79039 | 219111_s_at | 0.1425 | 0.1259 | |
| GSE53622 | DDX54 | 79039 | 66314 | 0.2526 | 0.0002 | |
| GSE53624 | DDX54 | 79039 | 66314 | 0.5435 | 0.0000 | |
| GSE63941 | DDX54 | 79039 | 219111_s_at | 0.1825 | 0.5218 | |
| GSE77861 | DDX54 | 79039 | 225428_s_at | 0.0385 | 0.8238 | |
| GSE97050 | DDX54 | 79039 | A_32_P430359 | 0.0364 | 0.8926 | |
| SRP007169 | DDX54 | 79039 | RNAseq | 0.8239 | 0.0582 | |
| SRP008496 | DDX54 | 79039 | RNAseq | 0.9219 | 0.0020 | |
| SRP064894 | DDX54 | 79039 | RNAseq | 0.4240 | 0.0217 | |
| SRP133303 | DDX54 | 79039 | RNAseq | 0.2578 | 0.1477 | |
| SRP159526 | DDX54 | 79039 | RNAseq | 0.2913 | 0.0807 | |
| SRP193095 | DDX54 | 79039 | RNAseq | 0.2612 | 0.0027 | |
| SRP219564 | DDX54 | 79039 | RNAseq | 0.3070 | 0.3035 | |
| TCGA | DDX54 | 79039 | RNAseq | 0.1025 | 0.0255 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DDX54 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDX54:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX54 | 79039 | 4 | 3 | 23 | |
| GSE20123 | DDX54 | 79039 | 4 | 3 | 23 | |
| GSE43470 | DDX54 | 79039 | 2 | 0 | 41 | |
| GSE46452 | DDX54 | 79039 | 9 | 1 | 49 | |
| GSE47630 | DDX54 | 79039 | 9 | 3 | 28 | |
| GSE54993 | DDX54 | 79039 | 0 | 5 | 65 | |
| GSE54994 | DDX54 | 79039 | 4 | 2 | 47 | |
| GSE60625 | DDX54 | 79039 | 0 | 0 | 11 | |
| GSE74703 | DDX54 | 79039 | 2 | 0 | 34 | |
| GSE74704 | DDX54 | 79039 | 2 | 2 | 16 | |
| TCGA | DDX54 | 79039 | 22 | 11 | 63 |
Total number of gains: 58; Total number of losses: 30; Total Number of normals: 400.
Somatic mutations of DDX54:
Generating mutation plots.
Highly correlated genes for DDX54:
Showing top 20/1471 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX54 | FBXO31 | 0.861255 | 3 | 0 | 3 |
| DDX54 | CWF19L1 | 0.805415 | 3 | 0 | 3 |
| DDX54 | A4GALT | 0.80263 | 3 | 0 | 3 |
| DDX54 | ZNF764 | 0.80246 | 3 | 0 | 3 |
| DDX54 | SPNS1 | 0.800002 | 3 | 0 | 3 |
| DDX54 | RP9 | 0.795398 | 3 | 0 | 3 |
| DDX54 | RUNDC1 | 0.784726 | 3 | 0 | 3 |
| DDX54 | SSBP4 | 0.779297 | 3 | 0 | 3 |
| DDX54 | ANKRD16 | 0.776506 | 3 | 0 | 3 |
| DDX54 | RPS19BP1 | 0.775541 | 4 | 0 | 4 |
| DDX54 | C1orf216 | 0.769711 | 3 | 0 | 3 |
| DDX54 | THEM4 | 0.763176 | 3 | 0 | 3 |
| DDX54 | LRRC58 | 0.760104 | 4 | 0 | 3 |
| DDX54 | CBLB | 0.760027 | 4 | 0 | 4 |
| DDX54 | FAM171B | 0.758779 | 3 | 0 | 3 |
| DDX54 | ALKBH6 | 0.75653 | 3 | 0 | 3 |
| DDX54 | C12orf57 | 0.750005 | 3 | 0 | 3 |
| DDX54 | ROMO1 | 0.748707 | 4 | 0 | 3 |
| DDX54 | ZNF322 | 0.74614 | 3 | 0 | 3 |
| DDX54 | EFTUD2 | 0.745873 | 6 | 0 | 6 |
For details and further investigation, click here
