| Full name: semaphorin 6D | Alias Symbol: KIAA1479|FLJ11598 | ||
| Type: protein-coding gene | Cytoband: 15q21.1 | ||
| Entrez ID: 80031 | HGNC ID: HGNC:16770 | Ensembl Gene: ENSG00000137872 | OMIM ID: 609295 |
| Drug and gene relationship at DGIdb | |||
Expression of SEMA6D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEMA6D | 80031 | 233801_s_at | 0.1414 | 0.5995 | |
| GSE20347 | SEMA6D | 80031 | 220574_at | 0.3029 | 0.0137 | |
| GSE23400 | SEMA6D | 80031 | 220574_at | 0.0397 | 0.4800 | |
| GSE26886 | SEMA6D | 80031 | 233801_s_at | 0.1536 | 0.4638 | |
| GSE29001 | SEMA6D | 80031 | 220574_at | 0.3952 | 0.1512 | |
| GSE38129 | SEMA6D | 80031 | 220574_at | 0.1382 | 0.3259 | |
| GSE45670 | SEMA6D | 80031 | 226492_at | 0.0530 | 0.9506 | |
| GSE53622 | SEMA6D | 80031 | 980 | 0.7532 | 0.0002 | |
| GSE53624 | SEMA6D | 80031 | 980 | 0.8292 | 0.0000 | |
| GSE63941 | SEMA6D | 80031 | 233801_s_at | -0.0725 | 0.8760 | |
| GSE77861 | SEMA6D | 80031 | 233801_s_at | -0.0403 | 0.7978 | |
| GSE97050 | SEMA6D | 80031 | A_24_P10226 | -0.0414 | 0.9461 | |
| SRP007169 | SEMA6D | 80031 | RNAseq | 5.6672 | 0.0018 | |
| SRP064894 | SEMA6D | 80031 | RNAseq | 0.7496 | 0.0360 | |
| SRP133303 | SEMA6D | 80031 | RNAseq | 1.3402 | 0.0126 | |
| SRP159526 | SEMA6D | 80031 | RNAseq | 1.5604 | 0.0000 | |
| SRP193095 | SEMA6D | 80031 | RNAseq | 0.6768 | 0.0909 | |
| SRP219564 | SEMA6D | 80031 | RNAseq | 0.2826 | 0.7271 | |
| TCGA | SEMA6D | 80031 | RNAseq | 0.1809 | 0.4572 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SEMA6D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEMA6D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEMA6D | 80031 | 3 | 5 | 22 | |
| GSE20123 | SEMA6D | 80031 | 3 | 5 | 22 | |
| GSE43470 | SEMA6D | 80031 | 5 | 4 | 34 | |
| GSE46452 | SEMA6D | 80031 | 3 | 7 | 49 | |
| GSE47630 | SEMA6D | 80031 | 8 | 10 | 22 | |
| GSE54993 | SEMA6D | 80031 | 4 | 6 | 60 | |
| GSE54994 | SEMA6D | 80031 | 5 | 7 | 41 | |
| GSE60625 | SEMA6D | 80031 | 4 | 0 | 7 | |
| GSE74703 | SEMA6D | 80031 | 5 | 3 | 28 | |
| GSE74704 | SEMA6D | 80031 | 1 | 4 | 15 | |
| TCGA | SEMA6D | 80031 | 10 | 17 | 69 |
Total number of gains: 51; Total number of losses: 68; Total Number of normals: 369.
Somatic mutations of SEMA6D:
Generating mutation plots.
Highly correlated genes for SEMA6D:
Showing top 20/148 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEMA6D | ABCA3 | 0.738741 | 3 | 0 | 3 |
| SEMA6D | ADCK1 | 0.735113 | 3 | 0 | 3 |
| SEMA6D | MED15 | 0.727406 | 3 | 0 | 3 |
| SEMA6D | GDI1 | 0.711378 | 4 | 0 | 3 |
| SEMA6D | LMBR1 | 0.698302 | 3 | 0 | 3 |
| SEMA6D | B3GALT2 | 0.687502 | 3 | 0 | 3 |
| SEMA6D | ZBED1 | 0.684204 | 3 | 0 | 3 |
| SEMA6D | ARL10 | 0.682561 | 3 | 0 | 3 |
| SEMA6D | ZMYM3 | 0.680757 | 4 | 0 | 3 |
| SEMA6D | INPP5E | 0.678426 | 3 | 0 | 3 |
| SEMA6D | FBXO33 | 0.666364 | 3 | 0 | 3 |
| SEMA6D | STRAP | 0.666194 | 3 | 0 | 3 |
| SEMA6D | IGBP1 | 0.665541 | 3 | 0 | 3 |
| SEMA6D | AP3B2 | 0.665326 | 4 | 0 | 4 |
| SEMA6D | TCEAL4 | 0.664611 | 4 | 0 | 3 |
| SEMA6D | RPGR | 0.664414 | 3 | 0 | 3 |
| SEMA6D | ZCCHC3 | 0.660282 | 3 | 0 | 3 |
| SEMA6D | PPARA | 0.65963 | 3 | 0 | 3 |
| SEMA6D | MLF2 | 0.65523 | 3 | 0 | 3 |
| SEMA6D | POU2F1 | 0.652563 | 3 | 0 | 3 |
For details and further investigation, click here
