| Full name: mediator complex subunit 15 | Alias Symbol: TIG-1|CAG7A|Arc105 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 51586 | HGNC ID: HGNC:14248 | Ensembl Gene: ENSG00000099917 | OMIM ID: 607372 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MED15:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MED15 | 51586 | 222175_s_at | 0.3478 | 0.2415 | |
| GSE20347 | MED15 | 51586 | 222175_s_at | 0.0597 | 0.5791 | |
| GSE23400 | MED15 | 51586 | 222175_s_at | 0.4239 | 0.0000 | |
| GSE26886 | MED15 | 51586 | 222175_s_at | 0.3776 | 0.0291 | |
| GSE29001 | MED15 | 51586 | 222175_s_at | 0.1661 | 0.5851 | |
| GSE38129 | MED15 | 51586 | 222175_s_at | 0.0998 | 0.4111 | |
| GSE45670 | MED15 | 51586 | 222175_s_at | 0.5873 | 0.0142 | |
| GSE53622 | MED15 | 51586 | 107857 | 0.2901 | 0.0002 | |
| GSE53624 | MED15 | 51586 | 107857 | 0.4618 | 0.0000 | |
| GSE63941 | MED15 | 51586 | 222175_s_at | 0.6880 | 0.1312 | |
| GSE77861 | MED15 | 51586 | 222175_s_at | 0.4545 | 0.0128 | |
| GSE97050 | MED15 | 51586 | A_24_P207727 | 0.1650 | 0.4601 | |
| SRP007169 | MED15 | 51586 | RNAseq | 0.2951 | 0.5032 | |
| SRP008496 | MED15 | 51586 | RNAseq | 0.0826 | 0.7725 | |
| SRP064894 | MED15 | 51586 | RNAseq | 0.7767 | 0.0001 | |
| SRP133303 | MED15 | 51586 | RNAseq | 0.2209 | 0.1273 | |
| SRP159526 | MED15 | 51586 | RNAseq | -0.0355 | 0.8977 | |
| SRP193095 | MED15 | 51586 | RNAseq | 0.5527 | 0.0009 | |
| SRP219564 | MED15 | 51586 | RNAseq | 0.7764 | 0.0234 | |
| TCGA | MED15 | 51586 | RNAseq | 0.1441 | 0.0054 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MED15 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MED15:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MED15 | 51586 | 6 | 7 | 17 | |
| GSE20123 | MED15 | 51586 | 6 | 7 | 17 | |
| GSE43470 | MED15 | 51586 | 4 | 7 | 32 | |
| GSE46452 | MED15 | 51586 | 33 | 1 | 25 | |
| GSE47630 | MED15 | 51586 | 8 | 5 | 27 | |
| GSE54993 | MED15 | 51586 | 3 | 6 | 61 | |
| GSE54994 | MED15 | 51586 | 11 | 7 | 35 | |
| GSE60625 | MED15 | 51586 | 5 | 0 | 6 | |
| GSE74703 | MED15 | 51586 | 4 | 5 | 27 | |
| GSE74704 | MED15 | 51586 | 3 | 4 | 13 | |
| TCGA | MED15 | 51586 | 27 | 17 | 52 |
Total number of gains: 110; Total number of losses: 66; Total Number of normals: 312.
Somatic mutations of MED15:
Generating mutation plots.
Highly correlated genes for MED15:
Showing top 20/978 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MED15 | ZNF518B | 0.797671 | 3 | 0 | 3 |
| MED15 | RNF130 | 0.773291 | 3 | 0 | 3 |
| MED15 | MRPS35 | 0.772288 | 3 | 0 | 3 |
| MED15 | KHNYN | 0.771087 | 3 | 0 | 3 |
| MED15 | JMJD4 | 0.745469 | 3 | 0 | 3 |
| MED15 | PLEKHO2 | 0.738463 | 3 | 0 | 3 |
| MED15 | WIZ | 0.731601 | 5 | 0 | 5 |
| MED15 | SEMA6D | 0.727406 | 3 | 0 | 3 |
| MED15 | ZNF830 | 0.724152 | 3 | 0 | 3 |
| MED15 | NDUFS2 | 0.720591 | 3 | 0 | 3 |
| MED15 | ARHGEF2 | 0.717934 | 3 | 0 | 3 |
| MED15 | TYK2 | 0.713837 | 6 | 0 | 5 |
| MED15 | DEPDC5 | 0.711874 | 3 | 0 | 3 |
| MED15 | SH2B3 | 0.710768 | 3 | 0 | 3 |
| MED15 | ETV6 | 0.710489 | 3 | 0 | 3 |
| MED15 | TMEM60 | 0.709743 | 3 | 0 | 3 |
| MED15 | PPP1R35 | 0.708666 | 4 | 0 | 4 |
| MED15 | MOB3C | 0.704571 | 3 | 0 | 3 |
| MED15 | PRR3 | 0.698379 | 3 | 0 | 3 |
| MED15 | CEP250 | 0.697743 | 3 | 0 | 3 |
For details and further investigation, click here
