| Full name: POU class 2 homeobox 1 | Alias Symbol: OCT1 | ||
| Type: protein-coding gene | Cytoband: 1q24.2 | ||
| Entrez ID: 5451 | HGNC ID: HGNC:9212 | Ensembl Gene: ENSG00000143190 | OMIM ID: 164175 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of POU2F1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POU2F1 | 5451 | 206789_s_at | 0.4449 | 0.2437 | |
| GSE20347 | POU2F1 | 5451 | 206789_s_at | 0.4329 | 0.0004 | |
| GSE23400 | POU2F1 | 5451 | 206789_s_at | 0.1527 | 0.0000 | |
| GSE26886 | POU2F1 | 5451 | 206789_s_at | 0.7105 | 0.0009 | |
| GSE29001 | POU2F1 | 5451 | 206789_s_at | 0.5615 | 0.0285 | |
| GSE38129 | POU2F1 | 5451 | 206789_s_at | 0.3725 | 0.0026 | |
| GSE45670 | POU2F1 | 5451 | 206789_s_at | 0.2347 | 0.0475 | |
| GSE53622 | POU2F1 | 5451 | 34342 | 0.5026 | 0.0000 | |
| GSE53624 | POU2F1 | 5451 | 34342 | 0.4764 | 0.0000 | |
| GSE63941 | POU2F1 | 5451 | 206789_s_at | 0.4176 | 0.1326 | |
| GSE77861 | POU2F1 | 5451 | 227254_at | 0.1995 | 0.0811 | |
| GSE97050 | POU2F1 | 5451 | A_23_P424002 | -0.0577 | 0.8328 | |
| SRP007169 | POU2F1 | 5451 | RNAseq | 0.5864 | 0.0996 | |
| SRP008496 | POU2F1 | 5451 | RNAseq | 0.5601 | 0.0063 | |
| SRP064894 | POU2F1 | 5451 | RNAseq | 0.1187 | 0.3834 | |
| SRP133303 | POU2F1 | 5451 | RNAseq | 0.2141 | 0.0611 | |
| SRP159526 | POU2F1 | 5451 | RNAseq | 0.4952 | 0.0413 | |
| SRP193095 | POU2F1 | 5451 | RNAseq | 0.2399 | 0.0020 | |
| SRP219564 | POU2F1 | 5451 | RNAseq | 0.1041 | 0.6447 | |
| TCGA | POU2F1 | 5451 | RNAseq | 0.2173 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POU2F1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POU2F1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POU2F1 | 5451 | 11 | 1 | 18 | |
| GSE20123 | POU2F1 | 5451 | 11 | 1 | 18 | |
| GSE43470 | POU2F1 | 5451 | 7 | 2 | 34 | |
| GSE46452 | POU2F1 | 5451 | 3 | 1 | 55 | |
| GSE47630 | POU2F1 | 5451 | 14 | 0 | 26 | |
| GSE54993 | POU2F1 | 5451 | 0 | 5 | 65 | |
| GSE54994 | POU2F1 | 5451 | 16 | 0 | 37 | |
| GSE60625 | POU2F1 | 5451 | 0 | 0 | 11 | |
| GSE74703 | POU2F1 | 5451 | 7 | 2 | 27 | |
| GSE74704 | POU2F1 | 5451 | 5 | 0 | 15 | |
| TCGA | POU2F1 | 5451 | 44 | 3 | 49 |
Total number of gains: 118; Total number of losses: 15; Total Number of normals: 355.
Somatic mutations of POU2F1:
Generating mutation plots.
Highly correlated genes for POU2F1:
Showing top 20/912 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POU2F1 | SLC5A3 | 0.784853 | 3 | 0 | 3 |
| POU2F1 | LMLN | 0.782019 | 3 | 0 | 3 |
| POU2F1 | NACC1 | 0.770684 | 4 | 0 | 4 |
| POU2F1 | CPLX1 | 0.767713 | 3 | 0 | 3 |
| POU2F1 | AARS2 | 0.763029 | 3 | 0 | 3 |
| POU2F1 | SLC22A5 | 0.762866 | 3 | 0 | 3 |
| POU2F1 | TFIP11 | 0.754082 | 3 | 0 | 3 |
| POU2F1 | R3HDM2 | 0.751286 | 3 | 0 | 3 |
| POU2F1 | SP3 | 0.749661 | 4 | 0 | 4 |
| POU2F1 | ZNF417 | 0.747689 | 3 | 0 | 3 |
| POU2F1 | ACAD9 | 0.740416 | 3 | 0 | 3 |
| POU2F1 | ZGPAT | 0.737199 | 4 | 0 | 4 |
| POU2F1 | MRPS6 | 0.734823 | 3 | 0 | 3 |
| POU2F1 | SPDYE3 | 0.733258 | 3 | 0 | 3 |
| POU2F1 | NOM1 | 0.729521 | 3 | 0 | 3 |
| POU2F1 | CELF1 | 0.723962 | 5 | 0 | 4 |
| POU2F1 | SRSF11 | 0.721612 | 5 | 0 | 5 |
| POU2F1 | DGCR8 | 0.720393 | 4 | 0 | 3 |
| POU2F1 | DCLRE1C | 0.718532 | 4 | 0 | 4 |
| POU2F1 | MRPL38 | 0.718113 | 4 | 0 | 4 |
For details and further investigation, click here
