| Full name: peroxisome proliferator activated receptor alpha | Alias Symbol: hPPAR|NR1C1 | ||
| Type: protein-coding gene | Cytoband: 22q13.31 | ||
| Entrez ID: 5465 | HGNC ID: HGNC:9232 | Ensembl Gene: ENSG00000186951 | OMIM ID: 170998 |
| Drug and gene relationship at DGIdb | |||
PPARA involved pathways:
Expression of PPARA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPARA | 5465 | 226978_at | -0.0366 | 0.9162 | |
| GSE20347 | PPARA | 5465 | 206870_at | -0.1005 | 0.0404 | |
| GSE23400 | PPARA | 5465 | 206870_at | -0.0121 | 0.6826 | |
| GSE26886 | PPARA | 5465 | 223437_at | 0.1129 | 0.6656 | |
| GSE29001 | PPARA | 5465 | 206870_at | -0.1300 | 0.2723 | |
| GSE38129 | PPARA | 5465 | 206870_at | -0.1276 | 0.0248 | |
| GSE45670 | PPARA | 5465 | 226978_at | -0.1418 | 0.5041 | |
| GSE53622 | PPARA | 5465 | 75172 | -0.0701 | 0.4161 | |
| GSE53624 | PPARA | 5465 | 40182 | -0.4658 | 0.0000 | |
| GSE63941 | PPARA | 5465 | 223437_at | -0.0816 | 0.9046 | |
| GSE77861 | PPARA | 5465 | 223437_at | 0.0247 | 0.9314 | |
| GSE97050 | PPARA | 5465 | A_23_P211643 | -0.5521 | 0.2502 | |
| SRP007169 | PPARA | 5465 | RNAseq | 0.3522 | 0.3018 | |
| SRP008496 | PPARA | 5465 | RNAseq | 0.3856 | 0.1085 | |
| SRP064894 | PPARA | 5465 | RNAseq | -0.0490 | 0.7936 | |
| SRP133303 | PPARA | 5465 | RNAseq | -0.3794 | 0.0520 | |
| SRP159526 | PPARA | 5465 | RNAseq | -0.4508 | 0.0631 | |
| SRP193095 | PPARA | 5465 | RNAseq | -0.2055 | 0.0756 | |
| SRP219564 | PPARA | 5465 | RNAseq | -0.3649 | 0.2124 | |
| TCGA | PPARA | 5465 | RNAseq | -0.2498 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPARA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPARA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPARA | 5465 | 5 | 6 | 19 | |
| GSE20123 | PPARA | 5465 | 4 | 5 | 21 | |
| GSE43470 | PPARA | 5465 | 2 | 6 | 35 | |
| GSE46452 | PPARA | 5465 | 31 | 2 | 26 | |
| GSE47630 | PPARA | 5465 | 9 | 4 | 27 | |
| GSE54993 | PPARA | 5465 | 3 | 6 | 61 | |
| GSE54994 | PPARA | 5465 | 11 | 7 | 35 | |
| GSE60625 | PPARA | 5465 | 5 | 0 | 6 | |
| GSE74703 | PPARA | 5465 | 2 | 4 | 30 | |
| GSE74704 | PPARA | 5465 | 2 | 3 | 15 | |
| TCGA | PPARA | 5465 | 27 | 16 | 53 |
Total number of gains: 101; Total number of losses: 59; Total Number of normals: 328.
Somatic mutations of PPARA:
Generating mutation plots.
Highly correlated genes for PPARA:
Showing top 20/89 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPARA | ARV1 | 0.763438 | 3 | 0 | 3 |
| PPARA | REEP5 | 0.73373 | 3 | 0 | 3 |
| PPARA | VAMP2 | 0.724976 | 3 | 0 | 3 |
| PPARA | OPHN1 | 0.719088 | 3 | 0 | 3 |
| PPARA | CCDC146 | 0.712297 | 3 | 0 | 3 |
| PPARA | RALGAPA2 | 0.705328 | 3 | 0 | 3 |
| PPARA | ANKRD46 | 0.701606 | 3 | 0 | 3 |
| PPARA | ALDH1A2 | 0.694215 | 3 | 0 | 3 |
| PPARA | OR7A10 | 0.693715 | 3 | 0 | 3 |
| PPARA | NDUFB1 | 0.689081 | 3 | 0 | 3 |
| PPARA | CLN5 | 0.687559 | 3 | 0 | 3 |
| PPARA | ADH1A | 0.686722 | 3 | 0 | 3 |
| PPARA | AP2A2 | 0.686397 | 3 | 0 | 3 |
| PPARA | VPS53 | 0.683711 | 3 | 0 | 3 |
| PPARA | HNF4G | 0.680178 | 3 | 0 | 3 |
| PPARA | TDRD3 | 0.662598 | 3 | 0 | 3 |
| PPARA | SEMA6D | 0.65963 | 3 | 0 | 3 |
| PPARA | SLC25A23 | 0.659441 | 3 | 0 | 3 |
| PPARA | FOXO3 | 0.651649 | 4 | 0 | 4 |
| PPARA | ZNF250 | 0.64923 | 4 | 0 | 3 |
For details and further investigation, click here
