| Full name: SH3 domain containing GRB2 like 3, endophilin A3 | Alias Symbol: SH3D2C|SH3P13|CNSA3|EEN-B2|HsT19371 | ||
| Type: protein-coding gene | Cytoband: 15q25.2 | ||
| Entrez ID: 6457 | HGNC ID: HGNC:10832 | Ensembl Gene: ENSG00000140600 | OMIM ID: 603362 |
| Drug and gene relationship at DGIdb | |||
Expression of SH3GL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH3GL3 | 6457 | 205637_s_at | -0.6316 | 0.2180 | |
| GSE20347 | SH3GL3 | 6457 | 205637_s_at | -0.5589 | 0.0374 | |
| GSE23400 | SH3GL3 | 6457 | 205637_s_at | -0.4604 | 0.0000 | |
| GSE26886 | SH3GL3 | 6457 | 205637_s_at | -1.4092 | 0.0020 | |
| GSE29001 | SH3GL3 | 6457 | 205637_s_at | -1.1258 | 0.0003 | |
| GSE38129 | SH3GL3 | 6457 | 205637_s_at | -0.2919 | 0.3097 | |
| GSE45670 | SH3GL3 | 6457 | 205637_s_at | -0.5973 | 0.1358 | |
| GSE53622 | SH3GL3 | 6457 | 26336 | -0.4766 | 0.0003 | |
| GSE53624 | SH3GL3 | 6457 | 26336 | -0.9110 | 0.0000 | |
| GSE63941 | SH3GL3 | 6457 | 205637_s_at | 1.7642 | 0.0497 | |
| GSE77861 | SH3GL3 | 6457 | 205637_s_at | -0.8294 | 0.0179 | |
| GSE97050 | SH3GL3 | 6457 | A_33_P3340961 | -0.5873 | 0.3552 | |
| SRP007169 | SH3GL3 | 6457 | RNAseq | -4.1461 | 0.0000 | |
| SRP064894 | SH3GL3 | 6457 | RNAseq | -1.9655 | 0.0000 | |
| SRP133303 | SH3GL3 | 6457 | RNAseq | -0.9940 | 0.0000 | |
| SRP159526 | SH3GL3 | 6457 | RNAseq | -0.0813 | 0.8951 | |
| SRP219564 | SH3GL3 | 6457 | RNAseq | -2.6367 | 0.0012 | |
| TCGA | SH3GL3 | 6457 | RNAseq | 0.7085 | 0.0288 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by SH3GL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH3GL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH3GL3 | 6457 | 8 | 0 | 22 | |
| GSE20123 | SH3GL3 | 6457 | 8 | 0 | 22 | |
| GSE43470 | SH3GL3 | 6457 | 4 | 4 | 35 | |
| GSE46452 | SH3GL3 | 6457 | 3 | 7 | 49 | |
| GSE47630 | SH3GL3 | 6457 | 8 | 10 | 22 | |
| GSE54993 | SH3GL3 | 6457 | 5 | 6 | 59 | |
| GSE54994 | SH3GL3 | 6457 | 6 | 6 | 41 | |
| GSE60625 | SH3GL3 | 6457 | 4 | 0 | 7 | |
| GSE74703 | SH3GL3 | 6457 | 4 | 2 | 30 | |
| GSE74704 | SH3GL3 | 6457 | 4 | 0 | 16 | |
| TCGA | SH3GL3 | 6457 | 14 | 15 | 67 |
Total number of gains: 68; Total number of losses: 50; Total Number of normals: 370.
Somatic mutations of SH3GL3:
Generating mutation plots.
Highly correlated genes for SH3GL3:
Showing top 20/403 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH3GL3 | BBS12 | 0.708175 | 3 | 0 | 3 |
| SH3GL3 | ZNF416 | 0.690694 | 3 | 0 | 3 |
| SH3GL3 | GPBP1 | 0.626267 | 3 | 0 | 3 |
| SH3GL3 | FUT11 | 0.625614 | 3 | 0 | 3 |
| SH3GL3 | STXBP5 | 0.625528 | 5 | 0 | 4 |
| SH3GL3 | UPRT | 0.625346 | 5 | 0 | 4 |
| SH3GL3 | LINC01343 | 0.6231 | 3 | 0 | 3 |
| SH3GL3 | GRPEL2 | 0.620563 | 4 | 0 | 3 |
| SH3GL3 | GNG7 | 0.61971 | 3 | 0 | 3 |
| SH3GL3 | PPM1K | 0.619099 | 5 | 0 | 3 |
| SH3GL3 | XPC | 0.618882 | 3 | 0 | 3 |
| SH3GL3 | PCBP1-AS1 | 0.617856 | 3 | 0 | 3 |
| SH3GL3 | LINC00852 | 0.616993 | 3 | 0 | 3 |
| SH3GL3 | ZNF619 | 0.615939 | 4 | 0 | 3 |
| SH3GL3 | TMEM185A | 0.614868 | 3 | 0 | 3 |
| SH3GL3 | UBE2E2 | 0.609527 | 3 | 0 | 3 |
| SH3GL3 | ZRANB1 | 0.609278 | 4 | 0 | 4 |
| SH3GL3 | STRADB | 0.608359 | 6 | 0 | 5 |
| SH3GL3 | BARHL1 | 0.606511 | 3 | 0 | 3 |
| SH3GL3 | SNORA68 | 0.605142 | 4 | 0 | 4 |
For details and further investigation, click here
