| Full name: syntaxin binding protein 5 | Alias Symbol: tomosyn|LLGL3 | ||
| Type: protein-coding gene | Cytoband: 6q24.3 | ||
| Entrez ID: 134957 | HGNC ID: HGNC:19665 | Ensembl Gene: ENSG00000164506 | OMIM ID: 604586 |
| Drug and gene relationship at DGIdb | |||
Expression of STXBP5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STXBP5 | 134957 | 226794_at | -0.7342 | 0.3745 | |
| GSE26886 | STXBP5 | 134957 | 226794_at | -1.6802 | 0.0000 | |
| GSE45670 | STXBP5 | 134957 | 235227_at | -0.9293 | 0.0033 | |
| GSE53622 | STXBP5 | 134957 | 5408 | -0.7677 | 0.0000 | |
| GSE53624 | STXBP5 | 134957 | 5408 | -1.3418 | 0.0000 | |
| GSE63941 | STXBP5 | 134957 | 226794_at | -1.3866 | 0.0322 | |
| GSE77861 | STXBP5 | 134957 | 235227_at | -0.8439 | 0.0173 | |
| GSE97050 | STXBP5 | 134957 | A_24_P29595 | 0.1484 | 0.5598 | |
| SRP007169 | STXBP5 | 134957 | RNAseq | -1.1038 | 0.0025 | |
| SRP008496 | STXBP5 | 134957 | RNAseq | -0.7196 | 0.0014 | |
| SRP064894 | STXBP5 | 134957 | RNAseq | -0.7950 | 0.0011 | |
| SRP133303 | STXBP5 | 134957 | RNAseq | -0.1855 | 0.4913 | |
| SRP159526 | STXBP5 | 134957 | RNAseq | -1.4475 | 0.0001 | |
| SRP193095 | STXBP5 | 134957 | RNAseq | -0.9349 | 0.0000 | |
| SRP219564 | STXBP5 | 134957 | RNAseq | -1.2877 | 0.0012 | |
| TCGA | STXBP5 | 134957 | RNAseq | -0.1443 | 0.0477 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by STXBP5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STXBP5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STXBP5 | 134957 | 2 | 4 | 24 | |
| GSE20123 | STXBP5 | 134957 | 2 | 3 | 25 | |
| GSE43470 | STXBP5 | 134957 | 5 | 0 | 38 | |
| GSE46452 | STXBP5 | 134957 | 3 | 11 | 45 | |
| GSE47630 | STXBP5 | 134957 | 9 | 4 | 27 | |
| GSE54993 | STXBP5 | 134957 | 3 | 2 | 65 | |
| GSE54994 | STXBP5 | 134957 | 8 | 8 | 37 | |
| GSE60625 | STXBP5 | 134957 | 0 | 1 | 10 | |
| GSE74703 | STXBP5 | 134957 | 4 | 0 | 32 | |
| GSE74704 | STXBP5 | 134957 | 0 | 1 | 19 | |
| TCGA | STXBP5 | 134957 | 14 | 20 | 62 |
Total number of gains: 50; Total number of losses: 54; Total Number of normals: 384.
Somatic mutations of STXBP5:
Generating mutation plots.
Highly correlated genes for STXBP5:
Showing top 20/1525 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STXBP5 | GOLGA4 | 0.816376 | 5 | 0 | 5 |
| STXBP5 | IMPACT | 0.806052 | 3 | 0 | 3 |
| STXBP5 | CYP2J2 | 0.804562 | 6 | 0 | 6 |
| STXBP5 | TMOD3 | 0.794064 | 6 | 0 | 6 |
| STXBP5 | HDHD2 | 0.79195 | 4 | 0 | 4 |
| STXBP5 | ACAA1 | 0.778847 | 6 | 0 | 6 |
| STXBP5 | C18orf25 | 0.778131 | 7 | 0 | 7 |
| STXBP5 | OSTF1 | 0.77676 | 7 | 0 | 7 |
| STXBP5 | CCNYL1 | 0.775306 | 5 | 0 | 5 |
| STXBP5 | NAA35 | 0.7718 | 3 | 0 | 3 |
| STXBP5 | VPS4B | 0.771094 | 7 | 0 | 7 |
| STXBP5 | SCP2 | 0.769938 | 8 | 0 | 8 |
| STXBP5 | SFTA2 | 0.769853 | 4 | 0 | 4 |
| STXBP5 | UGP2 | 0.7692 | 4 | 0 | 4 |
| STXBP5 | TMEM40 | 0.76867 | 6 | 0 | 6 |
| STXBP5 | BBIP1 | 0.767478 | 5 | 0 | 5 |
| STXBP5 | NT5C2 | 0.765385 | 7 | 0 | 7 |
| STXBP5 | KRT78 | 0.765278 | 6 | 0 | 6 |
| STXBP5 | MINK1 | 0.76448 | 3 | 0 | 3 |
| STXBP5 | SLC16A6 | 0.764192 | 7 | 0 | 7 |
For details and further investigation, click here
