| Full name: Src homology 2 domain containing F | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q21.1 | ||
| Entrez ID: 90525 | HGNC ID: HGNC:25116 | Ensembl Gene: ENSG00000138606 | OMIM ID: 617313 |
| Drug and gene relationship at DGIdb | |||
Expression of SHF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHF | 90525 | 228922_at | -0.0112 | 0.9813 | |
| GSE26886 | SHF | 90525 | 228922_at | 0.3455 | 0.0063 | |
| GSE45670 | SHF | 90525 | 228922_at | -0.1465 | 0.1728 | |
| GSE53622 | SHF | 90525 | 70649 | -0.1081 | 0.6210 | |
| GSE53624 | SHF | 90525 | 70649 | 0.2229 | 0.0814 | |
| GSE63941 | SHF | 90525 | 228922_at | -0.0780 | 0.6816 | |
| GSE77861 | SHF | 90525 | 228922_at | -0.0425 | 0.6789 | |
| GSE97050 | SHF | 90525 | A_32_P183904 | 0.3314 | 0.1628 | |
| SRP007169 | SHF | 90525 | RNAseq | 1.2830 | 0.1098 | |
| SRP064894 | SHF | 90525 | RNAseq | 0.3591 | 0.3639 | |
| SRP133303 | SHF | 90525 | RNAseq | -0.2847 | 0.2225 | |
| SRP159526 | SHF | 90525 | RNAseq | 0.0748 | 0.8100 | |
| SRP193095 | SHF | 90525 | RNAseq | 0.2883 | 0.1399 | |
| SRP219564 | SHF | 90525 | RNAseq | -0.3770 | 0.3904 | |
| TCGA | SHF | 90525 | RNAseq | -0.1153 | 0.4634 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SHF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHF | 90525 | 4 | 5 | 21 | |
| GSE20123 | SHF | 90525 | 4 | 5 | 21 | |
| GSE43470 | SHF | 90525 | 4 | 4 | 35 | |
| GSE46452 | SHF | 90525 | 3 | 7 | 49 | |
| GSE47630 | SHF | 90525 | 8 | 10 | 22 | |
| GSE54993 | SHF | 90525 | 5 | 5 | 60 | |
| GSE54994 | SHF | 90525 | 5 | 7 | 41 | |
| GSE60625 | SHF | 90525 | 4 | 0 | 7 | |
| GSE74703 | SHF | 90525 | 4 | 3 | 29 | |
| GSE74704 | SHF | 90525 | 2 | 3 | 15 | |
| TCGA | SHF | 90525 | 11 | 16 | 69 |
Total number of gains: 54; Total number of losses: 65; Total Number of normals: 369.
Somatic mutations of SHF:
Generating mutation plots.
Highly correlated genes for SHF:
Showing top 20/219 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHF | ECSIT | 0.784578 | 3 | 0 | 3 |
| SHF | FBXW4 | 0.756374 | 3 | 0 | 3 |
| SHF | BIVM | 0.751613 | 3 | 0 | 3 |
| SHF | FAM131B | 0.739627 | 3 | 0 | 3 |
| SHF | AGBL5 | 0.72747 | 3 | 0 | 3 |
| SHF | GYG2 | 0.712246 | 3 | 0 | 3 |
| SHF | WHAMM | 0.707186 | 3 | 0 | 3 |
| SHF | CCDC24 | 0.702012 | 3 | 0 | 3 |
| SHF | PHF8 | 0.695043 | 3 | 0 | 3 |
| SHF | ZNF584 | 0.694197 | 3 | 0 | 3 |
| SHF | BOLA1 | 0.690886 | 3 | 0 | 3 |
| SHF | ATAT1 | 0.690685 | 3 | 0 | 3 |
| SHF | PCSK2 | 0.685821 | 3 | 0 | 3 |
| SHF | ZBTB10 | 0.685057 | 4 | 0 | 3 |
| SHF | TEAD2 | 0.678339 | 4 | 0 | 4 |
| SHF | NR1H2 | 0.677937 | 3 | 0 | 3 |
| SHF | GRAMD1A | 0.673022 | 3 | 0 | 3 |
| SHF | UBE2D4 | 0.669956 | 3 | 0 | 3 |
| SHF | LMBR1 | 0.669274 | 4 | 0 | 3 |
| SHF | SLC29A3 | 0.668875 | 5 | 0 | 4 |
For details and further investigation, click here
