| Full name: F-box and WD repeat domain containing 4 | Alias Symbol: Fbw4|dactylin | ||
| Type: protein-coding gene | Cytoband: 10q24.32 | ||
| Entrez ID: 6468 | HGNC ID: HGNC:10847 | Ensembl Gene: ENSG00000107829 | OMIM ID: 608071 |
| Drug and gene relationship at DGIdb | |||
Expression of FBXW4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXW4 | 6468 | 221519_at | -0.3993 | 0.3794 | |
| GSE20347 | FBXW4 | 6468 | 221519_at | -0.3113 | 0.0219 | |
| GSE23400 | FBXW4 | 6468 | 221519_at | -0.1278 | 0.1102 | |
| GSE26886 | FBXW4 | 6468 | 221519_at | -0.1378 | 0.5592 | |
| GSE29001 | FBXW4 | 6468 | 221519_at | -0.2369 | 0.1870 | |
| GSE38129 | FBXW4 | 6468 | 221519_at | -0.3644 | 0.0025 | |
| GSE45670 | FBXW4 | 6468 | 221519_at | -0.4074 | 0.0005 | |
| GSE53622 | FBXW4 | 6468 | 31050 | -0.5306 | 0.0000 | |
| GSE53624 | FBXW4 | 6468 | 31050 | -0.5096 | 0.0000 | |
| GSE63941 | FBXW4 | 6468 | 221519_at | 0.3752 | 0.4002 | |
| GSE77861 | FBXW4 | 6468 | 221519_at | -0.0374 | 0.8520 | |
| GSE97050 | FBXW4 | 6468 | A_23_P342825 | -0.0615 | 0.8584 | |
| SRP007169 | FBXW4 | 6468 | RNAseq | -1.4070 | 0.0001 | |
| SRP008496 | FBXW4 | 6468 | RNAseq | -0.9368 | 0.0007 | |
| SRP064894 | FBXW4 | 6468 | RNAseq | 0.0082 | 0.9780 | |
| SRP133303 | FBXW4 | 6468 | RNAseq | -0.4057 | 0.0098 | |
| SRP159526 | FBXW4 | 6468 | RNAseq | -0.2291 | 0.5031 | |
| SRP193095 | FBXW4 | 6468 | RNAseq | -0.2702 | 0.0142 | |
| SRP219564 | FBXW4 | 6468 | RNAseq | -0.4323 | 0.3568 | |
| TCGA | FBXW4 | 6468 | RNAseq | -0.1360 | 0.0058 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FBXW4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXW4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXW4 | 6468 | 2 | 9 | 19 | |
| GSE20123 | FBXW4 | 6468 | 2 | 8 | 20 | |
| GSE43470 | FBXW4 | 6468 | 0 | 8 | 35 | |
| GSE46452 | FBXW4 | 6468 | 0 | 11 | 48 | |
| GSE47630 | FBXW4 | 6468 | 2 | 14 | 24 | |
| GSE54993 | FBXW4 | 6468 | 8 | 0 | 62 | |
| GSE54994 | FBXW4 | 6468 | 1 | 12 | 40 | |
| GSE60625 | FBXW4 | 6468 | 0 | 0 | 11 | |
| GSE74703 | FBXW4 | 6468 | 0 | 5 | 31 | |
| GSE74704 | FBXW4 | 6468 | 1 | 4 | 15 | |
| TCGA | FBXW4 | 6468 | 5 | 28 | 63 |
Total number of gains: 21; Total number of losses: 99; Total Number of normals: 368.
Somatic mutations of FBXW4:
Generating mutation plots.
Highly correlated genes for FBXW4:
Showing top 20/602 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXW4 | DOCK1 | 0.789373 | 3 | 0 | 3 |
| FBXW4 | SHF | 0.756374 | 3 | 0 | 3 |
| FBXW4 | RASD2 | 0.717065 | 3 | 0 | 3 |
| FBXW4 | ZRANB1 | 0.708215 | 3 | 0 | 3 |
| FBXW4 | KBTBD7 | 0.706234 | 3 | 0 | 3 |
| FBXW4 | KAT5 | 0.701717 | 4 | 0 | 3 |
| FBXW4 | ADH1C | 0.686401 | 4 | 0 | 3 |
| FBXW4 | IRF2BP1 | 0.684866 | 4 | 0 | 4 |
| FBXW4 | ZCRB1 | 0.679657 | 3 | 0 | 3 |
| FBXW4 | ALKBH7 | 0.679532 | 6 | 0 | 5 |
| FBXW4 | RASSF3 | 0.67797 | 3 | 0 | 3 |
| FBXW4 | ARL6 | 0.676165 | 3 | 0 | 3 |
| FBXW4 | ZNF844 | 0.673071 | 4 | 0 | 4 |
| FBXW4 | PAN2 | 0.671628 | 3 | 0 | 3 |
| FBXW4 | CHADL | 0.665649 | 4 | 0 | 3 |
| FBXW4 | SLC4A4 | 0.662718 | 5 | 0 | 4 |
| FBXW4 | C17orf97 | 0.662258 | 3 | 0 | 3 |
| FBXW4 | NDUFA13 | 0.662142 | 4 | 0 | 3 |
| FBXW4 | ANAPC16 | 0.661783 | 5 | 0 | 4 |
| FBXW4 | FAM102B | 0.660912 | 3 | 0 | 3 |
For details and further investigation, click here
