| Full name: proprotein convertase subtilisin/kexin type 2 | Alias Symbol: PC2|SPC2 | ||
| Type: protein-coding gene | Cytoband: 20p12.1 | ||
| Entrez ID: 5126 | HGNC ID: HGNC:8744 | Ensembl Gene: ENSG00000125851 | OMIM ID: 162151 |
| Drug and gene relationship at DGIdb | |||
Expression of PCSK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCSK2 | 5126 | 204870_s_at | -0.4286 | 0.6386 | |
| GSE20347 | PCSK2 | 5126 | 204870_s_at | -0.0768 | 0.3836 | |
| GSE23400 | PCSK2 | 5126 | 204870_s_at | -0.1950 | 0.0000 | |
| GSE26886 | PCSK2 | 5126 | 204870_s_at | -0.0136 | 0.9365 | |
| GSE29001 | PCSK2 | 5126 | 204870_s_at | -0.2292 | 0.0714 | |
| GSE38129 | PCSK2 | 5126 | 204870_s_at | -0.3682 | 0.0039 | |
| GSE45670 | PCSK2 | 5126 | 204870_s_at | -0.3133 | 0.0239 | |
| GSE53622 | PCSK2 | 5126 | 72138 | -3.0275 | 0.0000 | |
| GSE53624 | PCSK2 | 5126 | 72138 | -3.0777 | 0.0000 | |
| GSE63941 | PCSK2 | 5126 | 204870_s_at | -0.1453 | 0.5417 | |
| GSE77861 | PCSK2 | 5126 | 204870_s_at | -0.0382 | 0.7700 | |
| GSE97050 | PCSK2 | 5126 | A_23_P79968 | -0.7955 | 0.2151 | |
| SRP064894 | PCSK2 | 5126 | RNAseq | -1.4509 | 0.0117 | |
| SRP133303 | PCSK2 | 5126 | RNAseq | -0.4688 | 0.6556 | |
| SRP159526 | PCSK2 | 5126 | RNAseq | -1.3235 | 0.0303 | |
| TCGA | PCSK2 | 5126 | RNAseq | -1.8840 | 0.0138 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by PCSK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCSK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCSK2 | 5126 | 11 | 2 | 17 | |
| GSE20123 | PCSK2 | 5126 | 11 | 2 | 17 | |
| GSE43470 | PCSK2 | 5126 | 11 | 1 | 31 | |
| GSE46452 | PCSK2 | 5126 | 27 | 1 | 31 | |
| GSE47630 | PCSK2 | 5126 | 17 | 4 | 19 | |
| GSE54993 | PCSK2 | 5126 | 0 | 15 | 55 | |
| GSE54994 | PCSK2 | 5126 | 26 | 2 | 25 | |
| GSE60625 | PCSK2 | 5126 | 0 | 0 | 11 | |
| GSE74703 | PCSK2 | 5126 | 8 | 1 | 27 | |
| GSE74704 | PCSK2 | 5126 | 6 | 2 | 12 | |
| TCGA | PCSK2 | 5126 | 43 | 10 | 43 |
Total number of gains: 160; Total number of losses: 40; Total Number of normals: 288.
Somatic mutations of PCSK2:
Generating mutation plots.
Highly correlated genes for PCSK2:
Showing top 20/880 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCSK2 | CLEC3B | 0.828217 | 3 | 0 | 3 |
| PCSK2 | XKR4 | 0.813251 | 4 | 0 | 4 |
| PCSK2 | CYP21A2 | 0.808387 | 3 | 0 | 3 |
| PCSK2 | UBXN10 | 0.796342 | 3 | 0 | 3 |
| PCSK2 | ANO5 | 0.792241 | 4 | 0 | 4 |
| PCSK2 | RASL11A | 0.759309 | 3 | 0 | 3 |
| PCSK2 | TTLL11 | 0.751137 | 3 | 0 | 3 |
| PCSK2 | C3orf70 | 0.748901 | 4 | 0 | 4 |
| PCSK2 | RBFOX3 | 0.747317 | 3 | 0 | 3 |
| PCSK2 | LONRF2 | 0.745638 | 4 | 0 | 4 |
| PCSK2 | NCAM1 | 0.734788 | 6 | 0 | 6 |
| PCSK2 | NTN4 | 0.728535 | 4 | 0 | 4 |
| PCSK2 | NEXN | 0.724148 | 4 | 0 | 4 |
| PCSK2 | KCNMA1 | 0.723799 | 6 | 0 | 6 |
| PCSK2 | PARD3B | 0.723621 | 4 | 0 | 4 |
| PCSK2 | ATP1A2 | 0.722197 | 7 | 0 | 6 |
| PCSK2 | COL28A1 | 0.719624 | 3 | 0 | 3 |
| PCSK2 | NR2F1 | 0.716949 | 3 | 0 | 3 |
| PCSK2 | ABRA | 0.713577 | 3 | 0 | 3 |
| PCSK2 | ZNF470 | 0.711146 | 3 | 0 | 3 |
For details and further investigation, click here
