| Full name: ECSIT signalling integrator | Alias Symbol: SITPEC | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 51295 | HGNC ID: HGNC:29548 | Ensembl Gene: ENSG00000130159 | OMIM ID: 608388 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ECSIT involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of ECSIT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ECSIT | 51295 | 218225_at | 0.3199 | 0.6643 | |
| GSE20347 | ECSIT | 51295 | 218225_at | 0.1593 | 0.3001 | |
| GSE23400 | ECSIT | 51295 | 218225_at | 0.1101 | 0.1466 | |
| GSE26886 | ECSIT | 51295 | 218225_at | 0.7873 | 0.0000 | |
| GSE29001 | ECSIT | 51295 | 218225_at | 0.3473 | 0.1953 | |
| GSE38129 | ECSIT | 51295 | 218225_at | 0.0807 | 0.5207 | |
| GSE45670 | ECSIT | 51295 | 218225_at | 0.0567 | 0.7011 | |
| GSE53622 | ECSIT | 51295 | 7391 | -0.1715 | 0.0549 | |
| GSE53624 | ECSIT | 51295 | 7391 | 0.4205 | 0.0000 | |
| GSE63941 | ECSIT | 51295 | 218225_at | 0.9326 | 0.0229 | |
| GSE77861 | ECSIT | 51295 | 218225_at | 0.1782 | 0.3341 | |
| GSE97050 | ECSIT | 51295 | A_23_P119295 | -0.0509 | 0.8689 | |
| SRP007169 | ECSIT | 51295 | RNAseq | 0.1323 | 0.7251 | |
| SRP008496 | ECSIT | 51295 | RNAseq | 0.2921 | 0.3903 | |
| SRP064894 | ECSIT | 51295 | RNAseq | 0.5568 | 0.1416 | |
| SRP133303 | ECSIT | 51295 | RNAseq | -0.0419 | 0.8399 | |
| SRP159526 | ECSIT | 51295 | RNAseq | 0.2352 | 0.2322 | |
| SRP193095 | ECSIT | 51295 | RNAseq | -0.0086 | 0.9324 | |
| SRP219564 | ECSIT | 51295 | RNAseq | 0.8509 | 0.1838 | |
| TCGA | ECSIT | 51295 | RNAseq | -0.1225 | 0.0405 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ECSIT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ECSIT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ECSIT | 51295 | 4 | 2 | 24 | |
| GSE20123 | ECSIT | 51295 | 3 | 1 | 26 | |
| GSE43470 | ECSIT | 51295 | 2 | 6 | 35 | |
| GSE46452 | ECSIT | 51295 | 47 | 1 | 11 | |
| GSE47630 | ECSIT | 51295 | 4 | 7 | 29 | |
| GSE54993 | ECSIT | 51295 | 16 | 3 | 51 | |
| GSE54994 | ECSIT | 51295 | 6 | 13 | 34 | |
| GSE60625 | ECSIT | 51295 | 9 | 0 | 2 | |
| GSE74703 | ECSIT | 51295 | 2 | 4 | 30 | |
| GSE74704 | ECSIT | 51295 | 0 | 1 | 19 | |
| TCGA | ECSIT | 51295 | 16 | 12 | 68 |
Total number of gains: 109; Total number of losses: 50; Total Number of normals: 329.
Somatic mutations of ECSIT:
Generating mutation plots.
Highly correlated genes for ECSIT:
Showing top 20/893 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ECSIT | COMMD7 | 0.829284 | 3 | 0 | 3 |
| ECSIT | BOD1 | 0.810155 | 3 | 0 | 3 |
| ECSIT | FEZ1 | 0.791845 | 3 | 0 | 3 |
| ECSIT | PANK4 | 0.789924 | 3 | 0 | 3 |
| ECSIT | SHF | 0.784578 | 3 | 0 | 3 |
| ECSIT | ZNF496 | 0.784292 | 3 | 0 | 3 |
| ECSIT | DHX40 | 0.779347 | 3 | 0 | 3 |
| ECSIT | THAP5 | 0.776727 | 3 | 0 | 3 |
| ECSIT | ZNF627 | 0.776297 | 3 | 0 | 3 |
| ECSIT | STRADA | 0.775243 | 3 | 0 | 3 |
| ECSIT | RFX7 | 0.767746 | 3 | 0 | 3 |
| ECSIT | TLN2 | 0.765757 | 4 | 0 | 4 |
| ECSIT | SLC39A3 | 0.764166 | 3 | 0 | 3 |
| ECSIT | PELI3 | 0.762995 | 3 | 0 | 3 |
| ECSIT | MRPL32 | 0.762685 | 3 | 0 | 3 |
| ECSIT | TRIM21 | 0.755653 | 3 | 0 | 3 |
| ECSIT | INO80E | 0.754268 | 4 | 0 | 4 |
| ECSIT | MRPL9 | 0.75338 | 3 | 0 | 3 |
| ECSIT | PEX10 | 0.753175 | 3 | 0 | 3 |
| ECSIT | RPS19BP1 | 0.74605 | 5 | 0 | 5 |
For details and further investigation, click here
