| Full name: siah E3 ubiquitin protein ligase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q25.1 | ||
| Entrez ID: 6478 | HGNC ID: HGNC:10858 | Ensembl Gene: ENSG00000181788 | OMIM ID: 602213 |
| Drug and gene relationship at DGIdb | |||
Expression of SIAH2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIAH2 | 6478 | 209339_at | 0.3327 | 0.4888 | |
| GSE20347 | SIAH2 | 6478 | 209339_at | -0.1780 | 0.3630 | |
| GSE23400 | SIAH2 | 6478 | 209339_at | -0.0359 | 0.7258 | |
| GSE26886 | SIAH2 | 6478 | 209339_at | -1.2417 | 0.0000 | |
| GSE29001 | SIAH2 | 6478 | 209339_at | 0.0221 | 0.9397 | |
| GSE38129 | SIAH2 | 6478 | 209339_at | 0.0712 | 0.6913 | |
| GSE45670 | SIAH2 | 6478 | 209339_at | 0.1500 | 0.4678 | |
| GSE53622 | SIAH2 | 6478 | 33641 | -0.1666 | 0.0820 | |
| GSE53624 | SIAH2 | 6478 | 33641 | -0.1558 | 0.0123 | |
| GSE63941 | SIAH2 | 6478 | 209339_at | 1.5646 | 0.0163 | |
| GSE77861 | SIAH2 | 6478 | 209339_at | -0.0164 | 0.9671 | |
| GSE97050 | SIAH2 | 6478 | A_33_P3358342 | 0.1126 | 0.7503 | |
| SRP007169 | SIAH2 | 6478 | RNAseq | -0.5777 | 0.0521 | |
| SRP008496 | SIAH2 | 6478 | RNAseq | -0.6652 | 0.0000 | |
| SRP064894 | SIAH2 | 6478 | RNAseq | -0.0550 | 0.7990 | |
| SRP133303 | SIAH2 | 6478 | RNAseq | 0.0548 | 0.7984 | |
| SRP159526 | SIAH2 | 6478 | RNAseq | 0.3714 | 0.4117 | |
| SRP193095 | SIAH2 | 6478 | RNAseq | 0.1068 | 0.5529 | |
| SRP219564 | SIAH2 | 6478 | RNAseq | -0.3993 | 0.3880 | |
| TCGA | SIAH2 | 6478 | RNAseq | 0.2440 | 0.0003 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by SIAH2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIAH2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIAH2 | 6478 | 21 | 0 | 9 | |
| GSE20123 | SIAH2 | 6478 | 21 | 0 | 9 | |
| GSE43470 | SIAH2 | 6478 | 23 | 0 | 20 | |
| GSE46452 | SIAH2 | 6478 | 18 | 2 | 39 | |
| GSE47630 | SIAH2 | 6478 | 19 | 3 | 18 | |
| GSE54993 | SIAH2 | 6478 | 1 | 10 | 59 | |
| GSE54994 | SIAH2 | 6478 | 37 | 1 | 15 | |
| GSE60625 | SIAH2 | 6478 | 0 | 6 | 5 | |
| GSE74703 | SIAH2 | 6478 | 20 | 0 | 16 | |
| GSE74704 | SIAH2 | 6478 | 14 | 0 | 6 | |
| TCGA | SIAH2 | 6478 | 72 | 1 | 23 |
Total number of gains: 246; Total number of losses: 23; Total Number of normals: 219.
Somatic mutations of SIAH2:
Generating mutation plots.
Highly correlated genes for SIAH2:
Showing top 20/525 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIAH2 | CERS3 | 0.767734 | 3 | 0 | 3 |
| SIAH2 | KIF21A | 0.733483 | 3 | 0 | 3 |
| SIAH2 | FAM83B | 0.720141 | 3 | 0 | 3 |
| SIAH2 | FAM83G | 0.715512 | 3 | 0 | 3 |
| SIAH2 | ULK3 | 0.712593 | 3 | 0 | 3 |
| SIAH2 | NDFIP2 | 0.704413 | 3 | 0 | 3 |
| SIAH2 | SLC25A39 | 0.703471 | 6 | 0 | 6 |
| SIAH2 | RPUSD2 | 0.702897 | 3 | 0 | 3 |
| SIAH2 | CDA | 0.690776 | 3 | 0 | 3 |
| SIAH2 | ARHGAP32 | 0.68366 | 3 | 0 | 3 |
| SIAH2 | CYB561 | 0.682361 | 3 | 0 | 3 |
| SIAH2 | CHMP4C | 0.681295 | 3 | 0 | 3 |
| SIAH2 | GABPB1 | 0.680214 | 3 | 0 | 3 |
| SIAH2 | VPS25 | 0.678143 | 5 | 0 | 4 |
| SIAH2 | SLC22A15 | 0.674384 | 3 | 0 | 3 |
| SIAH2 | MARVELD2 | 0.672324 | 4 | 0 | 3 |
| SIAH2 | C1orf210 | 0.670388 | 3 | 0 | 3 |
| SIAH2 | PRDX5 | 0.669128 | 4 | 0 | 3 |
| SIAH2 | RCC2 | 0.666262 | 3 | 0 | 3 |
| SIAH2 | ZNF837 | 0.665858 | 3 | 0 | 3 |
For details and further investigation, click here
