| Full name: vacuolar protein sorting 25 homolog | Alias Symbol: MGC10540|EAP20|DERP9 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 84313 | HGNC ID: HGNC:28122 | Ensembl Gene: ENSG00000131475 | OMIM ID: 610907 |
| Drug and gene relationship at DGIdb | |||
Expression of VPS25:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS25 | 84313 | 224608_s_at | -0.5229 | 0.3931 | |
| GSE26886 | VPS25 | 84313 | 224608_s_at | -1.2376 | 0.0000 | |
| GSE45670 | VPS25 | 84313 | 224608_s_at | -0.1851 | 0.2137 | |
| GSE53622 | VPS25 | 84313 | 89466 | -0.8274 | 0.0000 | |
| GSE53624 | VPS25 | 84313 | 89466 | -0.6564 | 0.0000 | |
| GSE63941 | VPS25 | 84313 | 224608_s_at | 0.0558 | 0.8792 | |
| GSE77861 | VPS25 | 84313 | 224608_s_at | -0.4391 | 0.0700 | |
| GSE97050 | VPS25 | 84313 | A_23_P66599 | -0.0366 | 0.9500 | |
| SRP007169 | VPS25 | 84313 | RNAseq | -0.9206 | 0.0034 | |
| SRP008496 | VPS25 | 84313 | RNAseq | -0.9734 | 0.0000 | |
| SRP064894 | VPS25 | 84313 | RNAseq | -0.0816 | 0.7110 | |
| SRP133303 | VPS25 | 84313 | RNAseq | -0.1919 | 0.2722 | |
| SRP159526 | VPS25 | 84313 | RNAseq | -0.6065 | 0.0002 | |
| SRP193095 | VPS25 | 84313 | RNAseq | -0.6929 | 0.0000 | |
| SRP219564 | VPS25 | 84313 | RNAseq | -0.3420 | 0.3495 | |
| TCGA | VPS25 | 84313 | RNAseq | 0.1012 | 0.0525 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by VPS25 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS25:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS25 | 84313 | 6 | 2 | 22 | |
| GSE20123 | VPS25 | 84313 | 6 | 2 | 22 | |
| GSE43470 | VPS25 | 84313 | 1 | 2 | 40 | |
| GSE46452 | VPS25 | 84313 | 34 | 0 | 25 | |
| GSE47630 | VPS25 | 84313 | 8 | 1 | 31 | |
| GSE54993 | VPS25 | 84313 | 3 | 4 | 63 | |
| GSE54994 | VPS25 | 84313 | 8 | 5 | 40 | |
| GSE60625 | VPS25 | 84313 | 4 | 0 | 7 | |
| GSE74703 | VPS25 | 84313 | 1 | 1 | 34 | |
| GSE74704 | VPS25 | 84313 | 4 | 1 | 15 | |
| TCGA | VPS25 | 84313 | 22 | 7 | 67 |
Total number of gains: 97; Total number of losses: 25; Total Number of normals: 366.
Somatic mutations of VPS25:
Generating mutation plots.
Highly correlated genes for VPS25:
Showing top 20/1475 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS25 | CPT2 | 0.798289 | 3 | 0 | 3 |
| VPS25 | PSMD7 | 0.784556 | 3 | 0 | 3 |
| VPS25 | PPL | 0.780475 | 5 | 0 | 5 |
| VPS25 | TWF1 | 0.776234 | 5 | 0 | 5 |
| VPS25 | PSMD8 | 0.776186 | 3 | 0 | 3 |
| VPS25 | CSTB | 0.773658 | 5 | 0 | 5 |
| VPS25 | GTF3C1 | 0.769348 | 6 | 0 | 6 |
| VPS25 | ORMDL2 | 0.767896 | 5 | 0 | 4 |
| VPS25 | ANXA1 | 0.766211 | 5 | 0 | 5 |
| VPS25 | IL1RN | 0.765948 | 5 | 0 | 5 |
| VPS25 | PRSS2 | 0.76236 | 3 | 0 | 3 |
| VPS25 | STOML2 | 0.761223 | 3 | 0 | 3 |
| VPS25 | TMPRSS11E | 0.759801 | 5 | 0 | 5 |
| VPS25 | MFSD5 | 0.758688 | 8 | 0 | 7 |
| VPS25 | KRT13 | 0.758358 | 5 | 0 | 5 |
| VPS25 | CNFN | 0.754774 | 5 | 0 | 5 |
| VPS25 | ARPC1A | 0.751456 | 3 | 0 | 3 |
| VPS25 | SCEL | 0.749637 | 5 | 0 | 5 |
| VPS25 | SERPINB2 | 0.749021 | 5 | 0 | 5 |
| VPS25 | HIBCH | 0.748763 | 3 | 0 | 3 |
For details and further investigation, click here
