| Full name: peroxiredoxin 5 | Alias Symbol: ACR1|AOEB166|MGC142285|PRXV|PMP20|B166|PRDX6|PLP|SBBI10|MGC117264|MGC142283 | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 25824 | HGNC ID: HGNC:9355 | Ensembl Gene: ENSG00000126432 | OMIM ID: 606583 |
| Drug and gene relationship at DGIdb | |||
Expression of PRDX5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRDX5 | 25824 | 1560587_s_at | -0.6867 | 0.3802 | |
| GSE26886 | PRDX5 | 25824 | 1560587_s_at | -1.0416 | 0.0000 | |
| GSE45670 | PRDX5 | 25824 | 1560587_s_at | -0.3681 | 0.0556 | |
| GSE53622 | PRDX5 | 25824 | 96416 | -0.6003 | 0.0000 | |
| GSE53624 | PRDX5 | 25824 | 96416 | -0.6498 | 0.0000 | |
| GSE63941 | PRDX5 | 25824 | 1560587_s_at | 0.3742 | 0.4628 | |
| GSE77861 | PRDX5 | 25824 | 1560587_s_at | -0.6223 | 0.0222 | |
| GSE97050 | PRDX5 | 25824 | A_23_P12989 | -0.1267 | 0.8624 | |
| SRP007169 | PRDX5 | 25824 | RNAseq | -2.2628 | 0.0000 | |
| SRP008496 | PRDX5 | 25824 | RNAseq | -1.9055 | 0.0000 | |
| SRP064894 | PRDX5 | 25824 | RNAseq | -0.6631 | 0.0424 | |
| SRP133303 | PRDX5 | 25824 | RNAseq | -0.8178 | 0.0000 | |
| SRP159526 | PRDX5 | 25824 | RNAseq | -0.9082 | 0.0000 | |
| SRP193095 | PRDX5 | 25824 | RNAseq | -1.1886 | 0.0000 | |
| SRP219564 | PRDX5 | 25824 | RNAseq | -0.7313 | 0.1886 | |
| TCGA | PRDX5 | 25824 | RNAseq | -0.1017 | 0.0706 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by PRDX5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRDX5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRDX5 | 25824 | 6 | 5 | 19 | |
| GSE20123 | PRDX5 | 25824 | 6 | 5 | 19 | |
| GSE43470 | PRDX5 | 25824 | 1 | 3 | 39 | |
| GSE46452 | PRDX5 | 25824 | 8 | 4 | 47 | |
| GSE47630 | PRDX5 | 25824 | 4 | 6 | 30 | |
| GSE54993 | PRDX5 | 25824 | 3 | 0 | 67 | |
| GSE54994 | PRDX5 | 25824 | 5 | 5 | 43 | |
| GSE60625 | PRDX5 | 25824 | 0 | 3 | 8 | |
| GSE74703 | PRDX5 | 25824 | 1 | 1 | 34 | |
| GSE74704 | PRDX5 | 25824 | 4 | 3 | 13 | |
| TCGA | PRDX5 | 25824 | 21 | 9 | 66 |
Total number of gains: 59; Total number of losses: 44; Total Number of normals: 385.
Somatic mutations of PRDX5:
Generating mutation plots.
Highly correlated genes for PRDX5:
Showing top 20/1111 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRDX5 | TVP23B | 0.746694 | 3 | 0 | 3 |
| PRDX5 | PMVK | 0.728817 | 5 | 0 | 5 |
| PRDX5 | ENDOU | 0.71391 | 6 | 0 | 6 |
| PRDX5 | CWH43 | 0.713753 | 6 | 0 | 6 |
| PRDX5 | EPGN | 0.713226 | 3 | 0 | 3 |
| PRDX5 | DUOX1 | 0.709046 | 7 | 0 | 6 |
| PRDX5 | CTNND1 | 0.70801 | 3 | 0 | 3 |
| PRDX5 | RCAN3 | 0.707303 | 4 | 0 | 4 |
| PRDX5 | P4HB | 0.704105 | 3 | 0 | 3 |
| PRDX5 | CMAS | 0.70287 | 4 | 0 | 4 |
| PRDX5 | LYPD3 | 0.702713 | 7 | 0 | 7 |
| PRDX5 | TMOD3 | 0.702183 | 7 | 0 | 7 |
| PRDX5 | ARAP2 | 0.698648 | 3 | 0 | 3 |
| PRDX5 | DESI1 | 0.696868 | 4 | 0 | 4 |
| PRDX5 | BTBD11 | 0.695046 | 7 | 0 | 7 |
| PRDX5 | AMER2 | 0.694972 | 3 | 0 | 3 |
| PRDX5 | PDCD6IP | 0.693908 | 7 | 0 | 7 |
| PRDX5 | BDKRB2 | 0.693886 | 5 | 0 | 5 |
| PRDX5 | GMDS | 0.690857 | 6 | 0 | 5 |
| PRDX5 | TSSK2 | 0.689165 | 3 | 0 | 3 |
For details and further investigation, click here
