| Full name: charged multivesicular body protein 4C | Alias Symbol: MGC22825|Shax3|VPS32C | ||
| Type: protein-coding gene | Cytoband: 8q21.13 | ||
| Entrez ID: 92421 | HGNC ID: HGNC:30599 | Ensembl Gene: ENSG00000164695 | OMIM ID: 610899 |
| Drug and gene relationship at DGIdb | |||
Expression of CHMP4C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHMP4C | 92421 | 226803_at | 0.0024 | 0.9987 | |
| GSE26886 | CHMP4C | 92421 | 226803_at | -1.5950 | 0.0060 | |
| GSE45670 | CHMP4C | 92421 | 226803_at | -0.4161 | 0.0397 | |
| GSE53622 | CHMP4C | 92421 | 118341 | -0.3663 | 0.0624 | |
| GSE53624 | CHMP4C | 92421 | 118341 | -0.9608 | 0.0000 | |
| GSE63941 | CHMP4C | 92421 | 226803_at | 5.2440 | 0.0005 | |
| GSE77861 | CHMP4C | 92421 | 226803_at | -1.0731 | 0.0117 | |
| GSE97050 | CHMP4C | 92421 | A_23_P432598 | 0.4460 | 0.2494 | |
| SRP007169 | CHMP4C | 92421 | RNAseq | -2.9133 | 0.0000 | |
| SRP008496 | CHMP4C | 92421 | RNAseq | -2.2213 | 0.0000 | |
| SRP064894 | CHMP4C | 92421 | RNAseq | -1.1612 | 0.0006 | |
| SRP133303 | CHMP4C | 92421 | RNAseq | -0.7615 | 0.0015 | |
| SRP159526 | CHMP4C | 92421 | RNAseq | -0.9698 | 0.0339 | |
| SRP193095 | CHMP4C | 92421 | RNAseq | -1.3889 | 0.0000 | |
| SRP219564 | CHMP4C | 92421 | RNAseq | -1.3184 | 0.1669 | |
| TCGA | CHMP4C | 92421 | RNAseq | 0.0167 | 0.9042 |
Upregulated datasets: 1; Downregulated datasets: 6.
Survival by CHMP4C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHMP4C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHMP4C | 92421 | 15 | 1 | 14 | |
| GSE20123 | CHMP4C | 92421 | 17 | 1 | 12 | |
| GSE43470 | CHMP4C | 92421 | 18 | 1 | 24 | |
| GSE46452 | CHMP4C | 92421 | 21 | 0 | 38 | |
| GSE47630 | CHMP4C | 92421 | 23 | 0 | 17 | |
| GSE54993 | CHMP4C | 92421 | 0 | 19 | 51 | |
| GSE54994 | CHMP4C | 92421 | 30 | 0 | 23 | |
| GSE60625 | CHMP4C | 92421 | 0 | 4 | 7 | |
| GSE74703 | CHMP4C | 92421 | 15 | 1 | 20 | |
| GSE74704 | CHMP4C | 92421 | 11 | 0 | 9 | |
| TCGA | CHMP4C | 92421 | 51 | 2 | 43 |
Total number of gains: 201; Total number of losses: 29; Total Number of normals: 258.
Somatic mutations of CHMP4C:
Generating mutation plots.
Highly correlated genes for CHMP4C:
Showing top 20/904 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHMP4C | MARVELD2 | 0.839156 | 4 | 0 | 4 |
| CHMP4C | SORD | 0.757165 | 3 | 0 | 3 |
| CHMP4C | SH2D3A | 0.745845 | 5 | 0 | 4 |
| CHMP4C | RAB25 | 0.733428 | 8 | 0 | 8 |
| CHMP4C | GTF2IRD1 | 0.732306 | 3 | 0 | 3 |
| CHMP4C | RPP38 | 0.725901 | 3 | 0 | 3 |
| CHMP4C | SAMD9 | 0.722157 | 4 | 0 | 4 |
| CHMP4C | BAIAP2L1 | 0.717962 | 4 | 0 | 4 |
| CHMP4C | SLC25A39 | 0.714244 | 4 | 0 | 4 |
| CHMP4C | NIPAL1 | 0.714201 | 3 | 0 | 3 |
| CHMP4C | KDM2B | 0.70145 | 5 | 0 | 4 |
| CHMP4C | PIH1D2 | 0.70106 | 3 | 0 | 3 |
| CHMP4C | MARK2 | 0.70034 | 5 | 0 | 4 |
| CHMP4C | KIF21A | 0.698327 | 5 | 0 | 5 |
| CHMP4C | PPP1CC | 0.694706 | 3 | 0 | 3 |
| CHMP4C | ARHGAP27 | 0.69193 | 8 | 0 | 8 |
| CHMP4C | ALG14 | 0.691546 | 4 | 0 | 3 |
| CHMP4C | E2F8 | 0.6911 | 5 | 0 | 4 |
| CHMP4C | ARPC5L | 0.690729 | 4 | 0 | 4 |
| CHMP4C | BLOC1S1 | 0.690385 | 4 | 0 | 4 |
For details and further investigation, click here
