| Full name: single Ig and TIR domain containing | Alias Symbol: TIR8|IL-1R8 | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 59307 | HGNC ID: HGNC:30575 | Ensembl Gene: ENSG00000185187 | OMIM ID: 605478 |
| Drug and gene relationship at DGIdb | |||
Expression of SIGIRR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIGIRR | 59307 | 52940_at | -0.0592 | 0.9238 | |
| GSE20347 | SIGIRR | 59307 | 52940_at | -0.1205 | 0.5105 | |
| GSE23400 | SIGIRR | 59307 | 52940_at | -0.1338 | 0.0340 | |
| GSE26886 | SIGIRR | 59307 | 52940_at | 0.8493 | 0.0230 | |
| GSE29001 | SIGIRR | 59307 | 52940_at | -0.0483 | 0.9063 | |
| GSE38129 | SIGIRR | 59307 | 52940_at | -0.2944 | 0.2340 | |
| GSE45670 | SIGIRR | 59307 | 52940_at | -0.1566 | 0.3043 | |
| GSE53622 | SIGIRR | 59307 | 50278 | 0.0438 | 0.5612 | |
| GSE53624 | SIGIRR | 59307 | 56710 | -0.0323 | 0.7115 | |
| GSE63941 | SIGIRR | 59307 | 52940_at | 0.6589 | 0.0872 | |
| GSE77861 | SIGIRR | 59307 | 52940_at | 0.2502 | 0.3425 | |
| GSE97050 | SIGIRR | 59307 | A_33_P3259705 | -0.0236 | 0.9285 | |
| SRP007169 | SIGIRR | 59307 | RNAseq | -0.4095 | 0.3503 | |
| SRP008496 | SIGIRR | 59307 | RNAseq | -0.2956 | 0.3817 | |
| SRP064894 | SIGIRR | 59307 | RNAseq | -0.0247 | 0.9335 | |
| SRP133303 | SIGIRR | 59307 | RNAseq | -0.6139 | 0.0009 | |
| SRP159526 | SIGIRR | 59307 | RNAseq | -0.5550 | 0.0183 | |
| SRP193095 | SIGIRR | 59307 | RNAseq | 0.0545 | 0.8039 | |
| SRP219564 | SIGIRR | 59307 | RNAseq | 0.0640 | 0.9020 | |
| TCGA | SIGIRR | 59307 | RNAseq | -0.3790 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SIGIRR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIGIRR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIGIRR | 59307 | 1 | 11 | 18 | |
| GSE20123 | SIGIRR | 59307 | 1 | 12 | 17 | |
| GSE43470 | SIGIRR | 59307 | 1 | 10 | 32 | |
| GSE46452 | SIGIRR | 59307 | 7 | 8 | 44 | |
| GSE47630 | SIGIRR | 59307 | 4 | 12 | 24 | |
| GSE54993 | SIGIRR | 59307 | 3 | 2 | 65 | |
| GSE54994 | SIGIRR | 59307 | 1 | 12 | 40 | |
| GSE60625 | SIGIRR | 59307 | 0 | 0 | 11 | |
| GSE74703 | SIGIRR | 59307 | 1 | 8 | 27 | |
| GSE74704 | SIGIRR | 59307 | 0 | 8 | 12 | |
| TCGA | SIGIRR | 59307 | 8 | 38 | 50 |
Total number of gains: 27; Total number of losses: 121; Total Number of normals: 340.
Somatic mutations of SIGIRR:
Generating mutation plots.
Highly correlated genes for SIGIRR:
Showing top 20/215 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIGIRR | RELB | 0.808079 | 3 | 0 | 3 |
| SIGIRR | SCAMP5 | 0.775903 | 3 | 0 | 3 |
| SIGIRR | CHMP6 | 0.772258 | 3 | 0 | 3 |
| SIGIRR | SHISA7 | 0.768101 | 3 | 0 | 3 |
| SIGIRR | STAC3 | 0.753987 | 3 | 0 | 3 |
| SIGIRR | RUNDC3A | 0.750157 | 3 | 0 | 3 |
| SIGIRR | ATP13A2 | 0.745681 | 3 | 0 | 3 |
| SIGIRR | C19orf25 | 0.744074 | 4 | 0 | 4 |
| SIGIRR | GRIPAP1 | 0.742077 | 4 | 0 | 4 |
| SIGIRR | SPN | 0.737721 | 3 | 0 | 3 |
| SIGIRR | ZNF524 | 0.734954 | 4 | 0 | 4 |
| SIGIRR | TTC21A | 0.730866 | 3 | 0 | 3 |
| SIGIRR | CLSTN3 | 0.724554 | 4 | 0 | 3 |
| SIGIRR | MFSD10 | 0.72356 | 3 | 0 | 3 |
| SIGIRR | TNIP2 | 0.713355 | 3 | 0 | 3 |
| SIGIRR | LINC01278 | 0.712071 | 3 | 0 | 3 |
| SIGIRR | BMF | 0.709234 | 4 | 0 | 3 |
| SIGIRR | FBRSL1 | 0.709233 | 4 | 0 | 3 |
| SIGIRR | ATCAY | 0.70915 | 4 | 0 | 4 |
| SIGIRR | RHBDD3 | 0.708167 | 3 | 0 | 3 |
For details and further investigation, click here
