| Full name: RELB proto-oncogene, NF-kB subunit | Alias Symbol: REL-B | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 5971 | HGNC ID: HGNC:9956 | Ensembl Gene: ENSG00000104856 | OMIM ID: 604758 |
| Drug and gene relationship at DGIdb | |||
RELB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04064 | NF-kappa B signaling pathway | |
| hsa04380 | Osteoclast differentiation | |
| hsa05166 | HTLV-I infection | |
| hsa05169 | Epstein-Barr virus infection |
Expression of RELB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RELB | 5971 | 205205_at | 0.9800 | 0.0376 | |
| GSE20347 | RELB | 5971 | 205205_at | 0.6398 | 0.0000 | |
| GSE23400 | RELB | 5971 | 205205_at | 0.3889 | 0.0000 | |
| GSE26886 | RELB | 5971 | 205205_at | 1.2562 | 0.0000 | |
| GSE29001 | RELB | 5971 | 205205_at | 0.3830 | 0.0447 | |
| GSE38129 | RELB | 5971 | 205205_at | 0.7687 | 0.0000 | |
| GSE45670 | RELB | 5971 | 205205_at | 0.4818 | 0.0017 | |
| GSE53622 | RELB | 5971 | 117347 | 0.5928 | 0.0000 | |
| GSE53624 | RELB | 5971 | 117347 | 0.7443 | 0.0000 | |
| GSE63941 | RELB | 5971 | 205205_at | 0.3462 | 0.4772 | |
| GSE77861 | RELB | 5971 | 205205_at | 0.4285 | 0.0168 | |
| GSE97050 | RELB | 5971 | A_23_P55706 | 0.4944 | 0.2040 | |
| SRP007169 | RELB | 5971 | RNAseq | 1.1941 | 0.0078 | |
| SRP008496 | RELB | 5971 | RNAseq | 0.9447 | 0.0175 | |
| SRP064894 | RELB | 5971 | RNAseq | 1.1451 | 0.0001 | |
| SRP133303 | RELB | 5971 | RNAseq | 1.2949 | 0.0000 | |
| SRP159526 | RELB | 5971 | RNAseq | 1.1770 | 0.0015 | |
| SRP193095 | RELB | 5971 | RNAseq | 1.2102 | 0.0000 | |
| SRP219564 | RELB | 5971 | RNAseq | 1.1079 | 0.0266 | |
| TCGA | RELB | 5971 | RNAseq | 0.2734 | 0.0002 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by RELB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RELB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RELB | 5971 | 4 | 5 | 21 | |
| GSE20123 | RELB | 5971 | 4 | 4 | 22 | |
| GSE43470 | RELB | 5971 | 3 | 11 | 29 | |
| GSE46452 | RELB | 5971 | 45 | 1 | 13 | |
| GSE47630 | RELB | 5971 | 8 | 6 | 26 | |
| GSE54993 | RELB | 5971 | 17 | 4 | 49 | |
| GSE54994 | RELB | 5971 | 6 | 12 | 35 | |
| GSE60625 | RELB | 5971 | 9 | 0 | 2 | |
| GSE74703 | RELB | 5971 | 3 | 7 | 26 | |
| GSE74704 | RELB | 5971 | 4 | 2 | 14 | |
| TCGA | RELB | 5971 | 14 | 17 | 65 |
Total number of gains: 117; Total number of losses: 69; Total Number of normals: 302.
Somatic mutations of RELB:
Generating mutation plots.
Highly correlated genes for RELB:
Showing top 20/677 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RELB | SIGIRR | 0.808079 | 3 | 0 | 3 |
| RELB | HOXC9 | 0.781261 | 5 | 0 | 5 |
| RELB | ZNF526 | 0.755495 | 4 | 0 | 4 |
| RELB | KRT25 | 0.739753 | 3 | 0 | 3 |
| RELB | BMF | 0.736311 | 5 | 0 | 5 |
| RELB | CTSE | 0.730809 | 3 | 0 | 3 |
| RELB | LRWD1 | 0.722126 | 3 | 0 | 3 |
| RELB | ACVR2B | 0.720273 | 4 | 0 | 4 |
| RELB | PARP10 | 0.714201 | 3 | 0 | 3 |
| RELB | PSTPIP1 | 0.713188 | 3 | 0 | 3 |
| RELB | TNFAIP8L1 | 0.704858 | 5 | 0 | 5 |
| RELB | SDK1 | 0.704338 | 5 | 0 | 5 |
| RELB | RAG2 | 0.701358 | 4 | 0 | 3 |
| RELB | SHARPIN | 0.69538 | 5 | 0 | 4 |
| RELB | SLC8B1 | 0.692631 | 4 | 0 | 4 |
| RELB | PLEC | 0.692001 | 5 | 0 | 5 |
| RELB | LHFPL1 | 0.691399 | 3 | 0 | 3 |
| RELB | HAUS8 | 0.690138 | 6 | 0 | 5 |
| RELB | NFKBIE | 0.684033 | 11 | 0 | 10 |
| RELB | FUT1 | 0.68365 | 5 | 0 | 4 |
For details and further investigation, click here
