| Full name: salt inducible kinase 2 | Alias Symbol: KIAA0781|QIK|DKFZp434K1115|LOH11CR1I | ||
| Type: protein-coding gene | Cytoband: 11q23.1 | ||
| Entrez ID: 23235 | HGNC ID: HGNC:21680 | Ensembl Gene: ENSG00000170145 | OMIM ID: 608973 |
| Drug and gene relationship at DGIdb | |||
SIK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04922 | Glucagon signaling pathway |
Expression of SIK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIK2 | 23235 | 223430_at | -0.2027 | 0.6730 | |
| GSE20347 | SIK2 | 23235 | 213221_s_at | -0.1724 | 0.1058 | |
| GSE23400 | SIK2 | 23235 | 215752_at | -0.0569 | 0.0447 | |
| GSE26886 | SIK2 | 23235 | 223430_at | 0.1988 | 0.3596 | |
| GSE29001 | SIK2 | 23235 | 213221_s_at | 0.0377 | 0.9087 | |
| GSE38129 | SIK2 | 23235 | 213221_s_at | -0.3333 | 0.0278 | |
| GSE45670 | SIK2 | 23235 | 223430_at | -0.4155 | 0.0073 | |
| GSE53622 | SIK2 | 23235 | 38011 | -0.5653 | 0.0000 | |
| GSE53624 | SIK2 | 23235 | 38011 | -0.3071 | 0.0031 | |
| GSE63941 | SIK2 | 23235 | 213221_s_at | -1.7088 | 0.0003 | |
| GSE77861 | SIK2 | 23235 | 1556056_at | -0.1155 | 0.2498 | |
| GSE97050 | SIK2 | 23235 | A_33_P3216933 | -0.2423 | 0.3091 | |
| SRP007169 | SIK2 | 23235 | RNAseq | -0.0776 | 0.8247 | |
| SRP008496 | SIK2 | 23235 | RNAseq | 0.1241 | 0.5980 | |
| SRP064894 | SIK2 | 23235 | RNAseq | -0.2627 | 0.1964 | |
| SRP133303 | SIK2 | 23235 | RNAseq | -0.2292 | 0.1370 | |
| SRP159526 | SIK2 | 23235 | RNAseq | -0.0613 | 0.7568 | |
| SRP193095 | SIK2 | 23235 | RNAseq | -0.1175 | 0.4550 | |
| SRP219564 | SIK2 | 23235 | RNAseq | 0.3740 | 0.3878 | |
| TCGA | SIK2 | 23235 | RNAseq | -0.6010 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SIK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIK2 | 23235 | 0 | 12 | 18 | |
| GSE20123 | SIK2 | 23235 | 0 | 12 | 18 | |
| GSE43470 | SIK2 | 23235 | 2 | 6 | 35 | |
| GSE46452 | SIK2 | 23235 | 3 | 26 | 30 | |
| GSE47630 | SIK2 | 23235 | 2 | 19 | 19 | |
| GSE54993 | SIK2 | 23235 | 10 | 0 | 60 | |
| GSE54994 | SIK2 | 23235 | 5 | 19 | 29 | |
| GSE60625 | SIK2 | 23235 | 0 | 3 | 8 | |
| GSE74703 | SIK2 | 23235 | 1 | 4 | 31 | |
| GSE74704 | SIK2 | 23235 | 0 | 8 | 12 | |
| TCGA | SIK2 | 23235 | 6 | 48 | 42 |
Total number of gains: 29; Total number of losses: 157; Total Number of normals: 302.
Somatic mutations of SIK2:
Generating mutation plots.
Highly correlated genes for SIK2:
Showing top 20/628 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIK2 | MPND | 0.765498 | 3 | 0 | 3 |
| SIK2 | EGLN1 | 0.763329 | 3 | 0 | 3 |
| SIK2 | MRFAP1 | 0.734788 | 3 | 0 | 3 |
| SIK2 | UTP14C | 0.734546 | 3 | 0 | 3 |
| SIK2 | CLMP | 0.731791 | 3 | 0 | 3 |
| SIK2 | FKBP7 | 0.727411 | 3 | 0 | 3 |
| SIK2 | GPR135 | 0.718646 | 3 | 0 | 3 |
| SIK2 | OR7E24 | 0.716468 | 4 | 0 | 4 |
| SIK2 | PDE7B | 0.713544 | 4 | 0 | 4 |
| SIK2 | UBE2Q2 | 0.709239 | 3 | 0 | 3 |
| SIK2 | PNPLA8 | 0.706595 | 3 | 0 | 3 |
| SIK2 | EPM2AIP1 | 0.706532 | 3 | 0 | 3 |
| SIK2 | SARNP | 0.704254 | 3 | 0 | 3 |
| SIK2 | GLIS3 | 0.691074 | 3 | 0 | 3 |
| SIK2 | ZNF564 | 0.690674 | 3 | 0 | 3 |
| SIK2 | APEH | 0.686803 | 3 | 0 | 3 |
| SIK2 | RBKS | 0.683998 | 3 | 0 | 3 |
| SIK2 | ATXN3L | 0.680409 | 3 | 0 | 3 |
| SIK2 | ABCD4 | 0.680258 | 3 | 0 | 3 |
| SIK2 | KLHDC1 | 0.679814 | 4 | 0 | 3 |
For details and further investigation, click here
