| Full name: kelch domain containing 1 | Alias Symbol: MST025 | ||
| Type: protein-coding gene | Cytoband: 14q21.3 | ||
| Entrez ID: 122773 | HGNC ID: HGNC:19836 | Ensembl Gene: ENSG00000197776 | OMIM ID: 611281 |
| Drug and gene relationship at DGIdb | |||
Expression of KLHDC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHDC1 | 122773 | 1552733_at | -0.6218 | 0.3958 | |
| GSE26886 | KLHDC1 | 122773 | 1552733_at | -0.4995 | 0.0471 | |
| GSE45670 | KLHDC1 | 122773 | 1552733_at | -1.4168 | 0.0000 | |
| GSE53622 | KLHDC1 | 122773 | 101378 | -1.0328 | 0.0000 | |
| GSE53624 | KLHDC1 | 122773 | 101378 | -1.0564 | 0.0000 | |
| GSE63941 | KLHDC1 | 122773 | 1552733_at | -1.6663 | 0.0030 | |
| GSE77861 | KLHDC1 | 122773 | 1552733_at | -0.1042 | 0.5036 | |
| GSE97050 | KLHDC1 | 122773 | A_23_P422766 | -0.0571 | 0.7968 | |
| SRP007169 | KLHDC1 | 122773 | RNAseq | 0.3661 | 0.6464 | |
| SRP064894 | KLHDC1 | 122773 | RNAseq | -0.4176 | 0.2369 | |
| SRP133303 | KLHDC1 | 122773 | RNAseq | -0.8635 | 0.0021 | |
| SRP159526 | KLHDC1 | 122773 | RNAseq | -1.0999 | 0.0002 | |
| SRP193095 | KLHDC1 | 122773 | RNAseq | -0.7925 | 0.0000 | |
| SRP219564 | KLHDC1 | 122773 | RNAseq | -0.5688 | 0.2519 | |
| TCGA | KLHDC1 | 122773 | RNAseq | -0.8390 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by KLHDC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHDC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHDC1 | 122773 | 8 | 2 | 20 | |
| GSE20123 | KLHDC1 | 122773 | 8 | 3 | 19 | |
| GSE43470 | KLHDC1 | 122773 | 9 | 1 | 33 | |
| GSE46452 | KLHDC1 | 122773 | 16 | 3 | 40 | |
| GSE47630 | KLHDC1 | 122773 | 11 | 10 | 19 | |
| GSE54993 | KLHDC1 | 122773 | 3 | 9 | 58 | |
| GSE54994 | KLHDC1 | 122773 | 19 | 4 | 30 | |
| GSE60625 | KLHDC1 | 122773 | 0 | 2 | 9 | |
| GSE74703 | KLHDC1 | 122773 | 7 | 1 | 28 | |
| GSE74704 | KLHDC1 | 122773 | 3 | 2 | 15 | |
| TCGA | KLHDC1 | 122773 | 34 | 13 | 49 |
Total number of gains: 118; Total number of losses: 50; Total Number of normals: 320.
Somatic mutations of KLHDC1:
Generating mutation plots.
Highly correlated genes for KLHDC1:
Showing top 20/1016 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHDC1 | TK2 | 0.798524 | 3 | 0 | 3 |
| KLHDC1 | SETD2 | 0.772543 | 3 | 0 | 3 |
| KLHDC1 | HOXA4 | 0.771246 | 3 | 0 | 3 |
| KLHDC1 | NPY1R | 0.761983 | 3 | 0 | 3 |
| KLHDC1 | NFXL1 | 0.743236 | 3 | 0 | 3 |
| KLHDC1 | TNFSF12 | 0.738024 | 3 | 0 | 3 |
| KLHDC1 | KIAA0513 | 0.732286 | 3 | 0 | 3 |
| KLHDC1 | GOLGA4 | 0.724092 | 3 | 0 | 3 |
| KLHDC1 | CAPN7 | 0.723051 | 6 | 0 | 6 |
| KLHDC1 | GPRASP2 | 0.722638 | 3 | 0 | 3 |
| KLHDC1 | CRBN | 0.719085 | 4 | 0 | 4 |
| KLHDC1 | BCL6 | 0.717971 | 3 | 0 | 3 |
| KLHDC1 | RNF125 | 0.71109 | 5 | 0 | 5 |
| KLHDC1 | TCEAL5 | 0.709874 | 3 | 0 | 3 |
| KLHDC1 | ARHGAP15 | 0.706725 | 3 | 0 | 3 |
| KLHDC1 | MMRN1 | 0.706002 | 4 | 0 | 4 |
| KLHDC1 | C1QTNF7 | 0.705255 | 5 | 0 | 5 |
| KLHDC1 | RAB27A | 0.704948 | 3 | 0 | 3 |
| KLHDC1 | SYTL4 | 0.704307 | 3 | 0 | 3 |
| KLHDC1 | RNASE4 | 0.703003 | 5 | 0 | 5 |
For details and further investigation, click here
