| Full name: phosphodiesterase 7B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q23.3 | ||
| Entrez ID: 27115 | HGNC ID: HGNC:8792 | Ensembl Gene: ENSG00000171408 | OMIM ID: 604645 |
| Drug and gene relationship at DGIdb | |||
Expression of PDE7B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDE7B | 27115 | 230109_at | -0.3543 | 0.4570 | |
| GSE20347 | PDE7B | 27115 | 220343_at | -0.0821 | 0.3553 | |
| GSE23400 | PDE7B | 27115 | 220343_at | -0.1630 | 0.0000 | |
| GSE26886 | PDE7B | 27115 | 230109_at | 0.1799 | 0.4841 | |
| GSE29001 | PDE7B | 27115 | 220343_at | -0.0897 | 0.3887 | |
| GSE38129 | PDE7B | 27115 | 220343_at | -0.1744 | 0.0146 | |
| GSE45670 | PDE7B | 27115 | 230109_at | -0.7945 | 0.0012 | |
| GSE53622 | PDE7B | 27115 | 110092 | -1.2603 | 0.0000 | |
| GSE53624 | PDE7B | 27115 | 110092 | -0.5761 | 0.0006 | |
| GSE63941 | PDE7B | 27115 | 230109_at | -3.1369 | 0.0000 | |
| GSE77861 | PDE7B | 27115 | 243438_at | 0.0931 | 0.4505 | |
| GSE97050 | PDE7B | 27115 | A_33_P3301940 | -0.1973 | 0.4256 | |
| SRP007169 | PDE7B | 27115 | RNAseq | -0.1919 | 0.7443 | |
| SRP064894 | PDE7B | 27115 | RNAseq | 0.7469 | 0.0459 | |
| SRP133303 | PDE7B | 27115 | RNAseq | -0.7666 | 0.0171 | |
| SRP159526 | PDE7B | 27115 | RNAseq | -0.1999 | 0.6719 | |
| SRP193095 | PDE7B | 27115 | RNAseq | 0.1300 | 0.5407 | |
| SRP219564 | PDE7B | 27115 | RNAseq | 0.3580 | 0.6150 | |
| TCGA | PDE7B | 27115 | RNAseq | -0.8226 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PDE7B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDE7B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDE7B | 27115 | 3 | 4 | 23 | |
| GSE20123 | PDE7B | 27115 | 3 | 3 | 24 | |
| GSE43470 | PDE7B | 27115 | 5 | 0 | 38 | |
| GSE46452 | PDE7B | 27115 | 3 | 10 | 46 | |
| GSE47630 | PDE7B | 27115 | 10 | 4 | 26 | |
| GSE54993 | PDE7B | 27115 | 3 | 2 | 65 | |
| GSE54994 | PDE7B | 27115 | 9 | 7 | 37 | |
| GSE60625 | PDE7B | 27115 | 0 | 1 | 10 | |
| GSE74703 | PDE7B | 27115 | 4 | 0 | 32 | |
| GSE74704 | PDE7B | 27115 | 1 | 1 | 18 | |
| TCGA | PDE7B | 27115 | 12 | 18 | 66 |
Total number of gains: 53; Total number of losses: 50; Total Number of normals: 385.
Somatic mutations of PDE7B:
Generating mutation plots.
Highly correlated genes for PDE7B:
Showing top 20/848 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDE7B | CCDC102B | 0.803142 | 3 | 0 | 3 |
| PDE7B | MMRN1 | 0.801855 | 5 | 0 | 5 |
| PDE7B | CNRIP1 | 0.798907 | 6 | 0 | 6 |
| PDE7B | CPEB4 | 0.765084 | 3 | 0 | 3 |
| PDE7B | SRPX | 0.762737 | 4 | 0 | 4 |
| PDE7B | GIMAP6 | 0.757558 | 5 | 0 | 5 |
| PDE7B | PEG3 | 0.75211 | 4 | 0 | 3 |
| PDE7B | GIMAP1 | 0.749603 | 5 | 0 | 5 |
| PDE7B | GNG11 | 0.747298 | 7 | 0 | 6 |
| PDE7B | SYNC | 0.745681 | 3 | 0 | 3 |
| PDE7B | FIBIN | 0.742643 | 4 | 0 | 3 |
| PDE7B | TBX5-AS1 | 0.741903 | 3 | 0 | 3 |
| PDE7B | TNFSF12 | 0.738774 | 3 | 0 | 3 |
| PDE7B | TCF21 | 0.7376 | 7 | 0 | 7 |
| PDE7B | ST3GAL2 | 0.735932 | 3 | 0 | 3 |
| PDE7B | SEC22C | 0.735882 | 4 | 0 | 4 |
| PDE7B | KCNJ2 | 0.732065 | 3 | 0 | 3 |
| PDE7B | ARHGEF6 | 0.726107 | 6 | 0 | 5 |
| PDE7B | CLMP | 0.725807 | 5 | 0 | 5 |
| PDE7B | GIMAP5 | 0.725259 | 3 | 0 | 3 |
For details and further investigation, click here
