| Full name: G protein-coupled receptor 135 | Alias Symbol: HUMNPIIY20|PAFR | ||
| Type: protein-coding gene | Cytoband: 14q23.1 | ||
| Entrez ID: 64582 | HGNC ID: HGNC:19991 | Ensembl Gene: ENSG00000181619 | OMIM ID: 607970 |
| Drug and gene relationship at DGIdb | |||
Expression of GPR135:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR135 | 64582 | 211659_at | -0.0068 | 0.9879 | |
| GSE20347 | GPR135 | 64582 | 211659_at | 0.0606 | 0.4682 | |
| GSE23400 | GPR135 | 64582 | 211659_at | -0.0769 | 0.0646 | |
| GSE26886 | GPR135 | 64582 | 211659_at | 0.2986 | 0.0062 | |
| GSE29001 | GPR135 | 64582 | 211659_at | -0.2567 | 0.0398 | |
| GSE38129 | GPR135 | 64582 | 211659_at | -0.0469 | 0.6402 | |
| GSE45670 | GPR135 | 64582 | 217641_at | -0.1896 | 0.4060 | |
| GSE53622 | GPR135 | 64582 | 55282 | 0.0980 | 0.4887 | |
| GSE53624 | GPR135 | 64582 | 55282 | 0.2200 | 0.0144 | |
| GSE63941 | GPR135 | 64582 | 211659_at | 0.0464 | 0.8179 | |
| GSE77861 | GPR135 | 64582 | 217641_at | -0.0566 | 0.5590 | |
| GSE97050 | GPR135 | 64582 | A_23_P205575 | -0.1409 | 0.6217 | |
| SRP064894 | GPR135 | 64582 | RNAseq | 0.7415 | 0.0092 | |
| SRP133303 | GPR135 | 64582 | RNAseq | 0.5200 | 0.1372 | |
| SRP159526 | GPR135 | 64582 | RNAseq | 0.0635 | 0.8783 | |
| SRP193095 | GPR135 | 64582 | RNAseq | 1.0033 | 0.0000 | |
| SRP219564 | GPR135 | 64582 | RNAseq | 0.2181 | 0.6804 | |
| TCGA | GPR135 | 64582 | RNAseq | -0.1672 | 0.3651 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GPR135 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPR135:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR135 | 64582 | 8 | 3 | 19 | |
| GSE20123 | GPR135 | 64582 | 7 | 3 | 20 | |
| GSE43470 | GPR135 | 64582 | 8 | 2 | 33 | |
| GSE46452 | GPR135 | 64582 | 16 | 3 | 40 | |
| GSE47630 | GPR135 | 64582 | 11 | 9 | 20 | |
| GSE54993 | GPR135 | 64582 | 3 | 8 | 59 | |
| GSE54994 | GPR135 | 64582 | 19 | 4 | 30 | |
| GSE60625 | GPR135 | 64582 | 0 | 2 | 9 | |
| GSE74703 | GPR135 | 64582 | 7 | 2 | 27 | |
| GSE74704 | GPR135 | 64582 | 3 | 2 | 15 | |
| TCGA | GPR135 | 64582 | 32 | 14 | 50 |
Total number of gains: 114; Total number of losses: 52; Total Number of normals: 322.
Somatic mutations of GPR135:
Generating mutation plots.
Highly correlated genes for GPR135:
Showing top 20/424 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR135 | KLHL31 | 0.774328 | 3 | 0 | 3 |
| GPR135 | TRAK1 | 0.734949 | 3 | 0 | 3 |
| GPR135 | TBX18 | 0.727937 | 3 | 0 | 3 |
| GPR135 | SIK2 | 0.718646 | 3 | 0 | 3 |
| GPR135 | ITGA8 | 0.711193 | 3 | 0 | 3 |
| GPR135 | NFE2 | 0.710547 | 3 | 0 | 3 |
| GPR135 | CBL | 0.7069 | 4 | 0 | 4 |
| GPR135 | UBXN10 | 0.690338 | 3 | 0 | 3 |
| GPR135 | NMNAT2 | 0.689227 | 5 | 0 | 5 |
| GPR135 | CNTD1 | 0.685381 | 3 | 0 | 3 |
| GPR135 | ZNF484 | 0.684373 | 3 | 0 | 3 |
| GPR135 | CALM1 | 0.680288 | 4 | 0 | 4 |
| GPR135 | PI16 | 0.679879 | 3 | 0 | 3 |
| GPR135 | PRDM8 | 0.679823 | 4 | 0 | 4 |
| GPR135 | HRH1 | 0.676054 | 3 | 0 | 3 |
| GPR135 | KCNMB4 | 0.674408 | 4 | 0 | 4 |
| GPR135 | FAM43B | 0.670881 | 3 | 0 | 3 |
| GPR135 | ATXN1L | 0.669849 | 3 | 0 | 3 |
| GPR135 | LMO1 | 0.661994 | 4 | 0 | 3 |
| GPR135 | B4GALNT4 | 0.659793 | 4 | 0 | 4 |
For details and further investigation, click here
