| Full name: patatin like phospholipase domain containing 8 | Alias Symbol: IPLA2G|IPLA2-2|iPLA2gamma | ||
| Type: protein-coding gene | Cytoband: 7q31.1 | ||
| Entrez ID: 50640 | HGNC ID: HGNC:28900 | Ensembl Gene: ENSG00000135241 | OMIM ID: 612123 |
| Drug and gene relationship at DGIdb | |||
Expression of PNPLA8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PNPLA8 | 50640 | 223310_x_at | -0.4614 | 0.1399 | |
| GSE26886 | PNPLA8 | 50640 | 223310_x_at | -0.1315 | 0.6509 | |
| GSE45670 | PNPLA8 | 50640 | 223310_x_at | -0.0557 | 0.7189 | |
| GSE53622 | PNPLA8 | 50640 | 91128 | -0.2448 | 0.0004 | |
| GSE53624 | PNPLA8 | 50640 | 91128 | -0.1417 | 0.0043 | |
| GSE63941 | PNPLA8 | 50640 | 223310_x_at | -0.9193 | 0.0710 | |
| GSE77861 | PNPLA8 | 50640 | 223310_x_at | 0.0063 | 0.9855 | |
| GSE97050 | PNPLA8 | 50640 | A_23_P312718 | 0.0634 | 0.8069 | |
| SRP007169 | PNPLA8 | 50640 | RNAseq | -0.4860 | 0.1389 | |
| SRP008496 | PNPLA8 | 50640 | RNAseq | -0.3480 | 0.0929 | |
| SRP064894 | PNPLA8 | 50640 | RNAseq | -0.3099 | 0.2394 | |
| SRP133303 | PNPLA8 | 50640 | RNAseq | -0.0053 | 0.9739 | |
| SRP159526 | PNPLA8 | 50640 | RNAseq | -0.5619 | 0.1102 | |
| SRP193095 | PNPLA8 | 50640 | RNAseq | -0.2013 | 0.0953 | |
| SRP219564 | PNPLA8 | 50640 | RNAseq | -0.2507 | 0.5173 | |
| TCGA | PNPLA8 | 50640 | RNAseq | -0.0524 | 0.3128 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PNPLA8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PNPLA8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PNPLA8 | 50640 | 11 | 0 | 19 | |
| GSE20123 | PNPLA8 | 50640 | 11 | 0 | 19 | |
| GSE43470 | PNPLA8 | 50640 | 6 | 2 | 35 | |
| GSE46452 | PNPLA8 | 50640 | 9 | 2 | 48 | |
| GSE47630 | PNPLA8 | 50640 | 7 | 4 | 29 | |
| GSE54993 | PNPLA8 | 50640 | 2 | 9 | 59 | |
| GSE54994 | PNPLA8 | 50640 | 16 | 3 | 34 | |
| GSE60625 | PNPLA8 | 50640 | 0 | 0 | 11 | |
| GSE74703 | PNPLA8 | 50640 | 6 | 2 | 28 | |
| GSE74704 | PNPLA8 | 50640 | 7 | 0 | 13 | |
| TCGA | PNPLA8 | 50640 | 48 | 10 | 38 |
Total number of gains: 123; Total number of losses: 32; Total Number of normals: 333.
Somatic mutations of PNPLA8:
Generating mutation plots.
Highly correlated genes for PNPLA8:
Showing top 20/193 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PNPLA8 | BCAS2 | 0.782956 | 3 | 0 | 3 |
| PNPLA8 | GCC2 | 0.767414 | 3 | 0 | 3 |
| PNPLA8 | ZMAT3 | 0.767182 | 3 | 0 | 3 |
| PNPLA8 | TMUB2 | 0.759763 | 3 | 0 | 3 |
| PNPLA8 | CWC22 | 0.750367 | 3 | 0 | 3 |
| PNPLA8 | CYP2C19 | 0.747567 | 3 | 0 | 3 |
| PNPLA8 | NR2C1 | 0.747076 | 3 | 0 | 3 |
| PNPLA8 | PINK1 | 0.743486 | 4 | 0 | 3 |
| PNPLA8 | BECN1 | 0.741284 | 4 | 0 | 3 |
| PNPLA8 | BBS7 | 0.733541 | 3 | 0 | 3 |
| PNPLA8 | TTC37 | 0.731417 | 3 | 0 | 3 |
| PNPLA8 | KIF1B | 0.730858 | 3 | 0 | 3 |
| PNPLA8 | UBE2G2 | 0.730852 | 3 | 0 | 3 |
| PNPLA8 | RHBDD1 | 0.730725 | 3 | 0 | 3 |
| PNPLA8 | HEMK1 | 0.72905 | 3 | 0 | 3 |
| PNPLA8 | ACSL3 | 0.725069 | 3 | 0 | 3 |
| PNPLA8 | CNOT4 | 0.723791 | 3 | 0 | 3 |
| PNPLA8 | EZH1 | 0.721313 | 3 | 0 | 3 |
| PNPLA8 | TSPYL4 | 0.720184 | 3 | 0 | 3 |
| PNPLA8 | CETN2 | 0.718547 | 4 | 0 | 4 |
For details and further investigation, click here
