| Full name: SIX homeobox 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 147912 | HGNC ID: HGNC:10891 | Ensembl Gene: ENSG00000177045 | OMIM ID: 600963 |
| Drug and gene relationship at DGIdb | |||
Expression of SIX5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIX5 | 147912 | 229009_at | 0.3200 | 0.4238 | |
| GSE20347 | SIX5 | 147912 | 217661_x_at | 0.0534 | 0.4862 | |
| GSE23400 | SIX5 | 147912 | 217661_x_at | -0.0861 | 0.0050 | |
| GSE26886 | SIX5 | 147912 | 229009_at | 0.6118 | 0.0078 | |
| GSE29001 | SIX5 | 147912 | 217661_x_at | -0.0053 | 0.9772 | |
| GSE38129 | SIX5 | 147912 | 217661_x_at | -0.0549 | 0.3453 | |
| GSE45670 | SIX5 | 147912 | 229009_at | -0.0249 | 0.8750 | |
| GSE63941 | SIX5 | 147912 | 229009_at | 0.2777 | 0.5885 | |
| GSE77861 | SIX5 | 147912 | 229009_at | 0.2273 | 0.3849 | |
| GSE97050 | SIX5 | 147912 | A_33_P3412975 | -0.3345 | 0.3889 | |
| SRP007169 | SIX5 | 147912 | RNAseq | 0.1004 | 0.8310 | |
| SRP008496 | SIX5 | 147912 | RNAseq | 0.1729 | 0.6686 | |
| SRP064894 | SIX5 | 147912 | RNAseq | 0.5749 | 0.0315 | |
| SRP133303 | SIX5 | 147912 | RNAseq | 0.0124 | 0.9609 | |
| SRP159526 | SIX5 | 147912 | RNAseq | 0.7719 | 0.0168 | |
| SRP193095 | SIX5 | 147912 | RNAseq | 0.5474 | 0.0003 | |
| SRP219564 | SIX5 | 147912 | RNAseq | 0.2502 | 0.5831 | |
| TCGA | SIX5 | 147912 | RNAseq | 0.0578 | 0.2675 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SIX5 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SIX5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIX5 | 147912 | 4 | 5 | 21 | |
| GSE20123 | SIX5 | 147912 | 4 | 4 | 22 | |
| GSE43470 | SIX5 | 147912 | 3 | 11 | 29 | |
| GSE46452 | SIX5 | 147912 | 45 | 1 | 13 | |
| GSE47630 | SIX5 | 147912 | 8 | 7 | 25 | |
| GSE54993 | SIX5 | 147912 | 17 | 4 | 49 | |
| GSE54994 | SIX5 | 147912 | 5 | 13 | 35 | |
| GSE60625 | SIX5 | 147912 | 9 | 0 | 2 | |
| GSE74703 | SIX5 | 147912 | 3 | 7 | 26 | |
| GSE74704 | SIX5 | 147912 | 4 | 2 | 14 | |
| TCGA | SIX5 | 147912 | 16 | 15 | 65 |
Total number of gains: 118; Total number of losses: 69; Total Number of normals: 301.
Somatic mutations of SIX5:
Generating mutation plots.
Highly correlated genes for SIX5:
Showing top 20/632 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIX5 | SSBP4 | 0.803304 | 3 | 0 | 3 |
| SIX5 | PRICKLE1 | 0.781414 | 3 | 0 | 3 |
| SIX5 | PTP4A3 | 0.777039 | 3 | 0 | 3 |
| SIX5 | SLC23A2 | 0.771977 | 3 | 0 | 3 |
| SIX5 | ZNF280C | 0.770633 | 3 | 0 | 3 |
| SIX5 | CD151 | 0.767844 | 3 | 0 | 3 |
| SIX5 | LRP1 | 0.766639 | 3 | 0 | 3 |
| SIX5 | AKT1 | 0.764007 | 3 | 0 | 3 |
| SIX5 | GNAI2 | 0.750345 | 3 | 0 | 3 |
| SIX5 | EHMT2 | 0.744665 | 3 | 0 | 3 |
| SIX5 | B3GNT9 | 0.744469 | 4 | 0 | 4 |
| SIX5 | NENF | 0.743817 | 4 | 0 | 4 |
| SIX5 | RAB7B | 0.74377 | 3 | 0 | 3 |
| SIX5 | IL13RA2 | 0.738399 | 3 | 0 | 3 |
| SIX5 | GNG3 | 0.735742 | 3 | 0 | 3 |
| SIX5 | APCDD1L | 0.735626 | 3 | 0 | 3 |
| SIX5 | TTC7B | 0.733828 | 4 | 0 | 4 |
| SIX5 | TCF7L1 | 0.732152 | 3 | 0 | 3 |
| SIX5 | ZNF358 | 0.730725 | 3 | 0 | 3 |
| SIX5 | S1PR3 | 0.727972 | 3 | 0 | 3 |
For details and further investigation, click here
