LRP1

 

Full name: LDL receptor related protein 1 Alias Symbol: LRP|CD91|LRP1A|APOER
Type: protein-coding gene Cytoband: 12q13.3
Entrez ID: 4035 HGNC ID: HGNC:6692 Ensembl Gene: ENSG00000123384 OMIM ID: 107770
Drug and gene relationship at DGIdb

 

LRP1 involved pathways:

KEGG pathway Description View
hsa05010Alzheimer's disease

 

Expression of LRP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LRP1 4035 200785_s_at 0.1225 0.6992
GSE20347 LRP1 4035 200784_s_at 0.0211 0.8111
GSE23400 LRP1 4035 200785_s_at 0.1279 0.0855
GSE26886 LRP1 4035 200784_s_at 0.4870 0.0157
GSE29001 LRP1 4035 200785_s_at 0.0925 0.7332
GSE38129 LRP1 4035 200784_s_at -0.0650 0.4902
GSE45670 LRP1 4035 200784_s_at -0.0133 0.9334
GSE53622 LRP1 4035 133921 0.2281 0.0208
GSE53624 LRP1 4035 64670 -0.2008 0.0075
GSE63941 LRP1 4035 200784_s_at -0.2761 0.2244
GSE77861 LRP1 4035 200785_s_at 0.1399 0.5539
GSE97050 LRP1 4035 A_23_P124837 0.4783 0.2411
SRP007169 LRP1 4035 RNAseq 1.9553 0.0000
SRP008496 LRP1 4035 RNAseq 2.1454 0.0000
SRP064894 LRP1 4035 RNAseq 0.5397 0.0287
SRP133303 LRP1 4035 RNAseq 0.1163 0.6744
SRP159526 LRP1 4035 RNAseq 0.1065 0.7142
SRP193095 LRP1 4035 RNAseq 0.6727 0.0000
SRP219564 LRP1 4035 RNAseq 0.1189 0.7960
TCGA LRP1 4035 RNAseq -0.0736 0.2577

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by LRP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LRP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LRP1 4035 7 1 22
GSE20123 LRP1 4035 7 0 23
GSE43470 LRP1 4035 3 0 40
GSE46452 LRP1 4035 8 1 50
GSE47630 LRP1 4035 10 2 28
GSE54993 LRP1 4035 0 5 65
GSE54994 LRP1 4035 4 1 48
GSE60625 LRP1 4035 0 0 11
GSE74703 LRP1 4035 3 0 33
GSE74704 LRP1 4035 4 0 16
TCGA LRP1 4035 14 10 72

Total number of gains: 60; Total number of losses: 20; Total Number of normals: 408.  

 

Somatic mutations of LRP1:

 

Generating mutation plots.

 

Highly correlated genes for LRP1:

 

Showing top 20/515 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LRP1SIX50.766639303
LRP1GMPPA0.756151303
LRP1ACIN10.747823303
LRP1INTS10.718306303
LRP1LNP10.71322303
LRP1SOX170.707202303
LRP1MYPOP0.689883403
LRP1TNFRSF40.68665303
LRP1ZC3H30.684153303
LRP1BCAS40.683506303
LRP1ADRM10.68016303
LRP1MKNK10.676143303
LRP1ARF30.674826303
LRP1PACS10.672671403
LRP1SYNGR20.67064303
LRP1PRR120.670114303
LRP1EEFSEC0.66721404
LRP1IMPDH10.665847404
LRP1RBM140.665239404
LRP1SIK10.662958303

For details and further investigation, click here