| Full name: protein tyrosine phosphatase 4A3 | Alias Symbol: PRL-3|PRL-R|PRL3 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 11156 | HGNC ID: HGNC:9636 | Ensembl Gene: ENSG00000184489 | OMIM ID: 606449 |
| Drug and gene relationship at DGIdb | |||
Expression of PTP4A3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTP4A3 | 11156 | 206574_s_at | 0.7651 | 0.3955 | |
| GSE20347 | PTP4A3 | 11156 | 209695_at | 0.9949 | 0.0000 | |
| GSE23400 | PTP4A3 | 11156 | 209695_at | 0.1444 | 0.2603 | |
| GSE26886 | PTP4A3 | 11156 | 214223_at | 0.2573 | 0.0486 | |
| GSE29001 | PTP4A3 | 11156 | 209695_at | 0.9650 | 0.0663 | |
| GSE38129 | PTP4A3 | 11156 | 209695_at | 0.5014 | 0.0995 | |
| GSE45670 | PTP4A3 | 11156 | 214223_at | -0.1368 | 0.1192 | |
| GSE53622 | PTP4A3 | 11156 | 140248 | 0.7199 | 0.0000 | |
| GSE53624 | PTP4A3 | 11156 | 62582 | 0.6740 | 0.0000 | |
| GSE63941 | PTP4A3 | 11156 | 214223_at | -0.0031 | 0.9862 | |
| GSE77861 | PTP4A3 | 11156 | 214223_at | -0.1064 | 0.5066 | |
| GSE97050 | PTP4A3 | 11156 | A_33_P3315906 | 0.1105 | 0.7394 | |
| SRP007169 | PTP4A3 | 11156 | RNAseq | 3.2797 | 0.0001 | |
| SRP008496 | PTP4A3 | 11156 | RNAseq | 4.4214 | 0.0000 | |
| SRP064894 | PTP4A3 | 11156 | RNAseq | 1.3461 | 0.0000 | |
| SRP133303 | PTP4A3 | 11156 | RNAseq | 1.1900 | 0.0000 | |
| SRP159526 | PTP4A3 | 11156 | RNAseq | 1.4538 | 0.0003 | |
| SRP193095 | PTP4A3 | 11156 | RNAseq | 2.3309 | 0.0000 | |
| SRP219564 | PTP4A3 | 11156 | RNAseq | 0.2222 | 0.8203 | |
| TCGA | PTP4A3 | 11156 | RNAseq | -0.2644 | 0.0134 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by PTP4A3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTP4A3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTP4A3 | 11156 | 17 | 0 | 13 | |
| GSE20123 | PTP4A3 | 11156 | 16 | 0 | 14 | |
| GSE43470 | PTP4A3 | 11156 | 20 | 2 | 21 | |
| GSE46452 | PTP4A3 | 11156 | 27 | 0 | 32 | |
| GSE47630 | PTP4A3 | 11156 | 23 | 1 | 16 | |
| GSE54993 | PTP4A3 | 11156 | 0 | 25 | 45 | |
| GSE54994 | PTP4A3 | 11156 | 39 | 1 | 13 | |
| GSE60625 | PTP4A3 | 11156 | 3 | 4 | 4 | |
| GSE74703 | PTP4A3 | 11156 | 18 | 1 | 17 | |
| GSE74704 | PTP4A3 | 11156 | 10 | 0 | 10 | |
| TCGA | PTP4A3 | 11156 | 64 | 2 | 30 |
Total number of gains: 237; Total number of losses: 36; Total Number of normals: 215.
Somatic mutations of PTP4A3:
Generating mutation plots.
Highly correlated genes for PTP4A3:
Showing top 20/842 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTP4A3 | TRIM47 | 0.850746 | 3 | 0 | 3 |
| PTP4A3 | SIX5 | 0.777039 | 3 | 0 | 3 |
| PTP4A3 | ZDHHC1 | 0.771478 | 3 | 0 | 3 |
| PTP4A3 | SLC41A2 | 0.760251 | 3 | 0 | 3 |
| PTP4A3 | SSC5D | 0.756652 | 4 | 0 | 3 |
| PTP4A3 | SYNC | 0.74773 | 3 | 0 | 3 |
| PTP4A3 | ZNF683 | 0.744887 | 5 | 0 | 4 |
| PTP4A3 | ACY1 | 0.742328 | 4 | 0 | 4 |
| PTP4A3 | SIK1 | 0.733944 | 4 | 0 | 3 |
| PTP4A3 | SLC39A13 | 0.732322 | 4 | 0 | 4 |
| PTP4A3 | RAB11B | 0.730858 | 3 | 0 | 3 |
| PTP4A3 | ABHD16B | 0.728564 | 3 | 0 | 3 |
| PTP4A3 | ACTN1 | 0.724724 | 5 | 0 | 5 |
| PTP4A3 | GLIS2 | 0.722924 | 3 | 0 | 3 |
| PTP4A3 | RNF31 | 0.721713 | 3 | 0 | 3 |
| PTP4A3 | CDH24 | 0.721212 | 3 | 0 | 3 |
| PTP4A3 | HCFC1R1 | 0.709549 | 6 | 0 | 6 |
| PTP4A3 | SARDH | 0.708668 | 4 | 0 | 3 |
| PTP4A3 | DERL3 | 0.707193 | 4 | 0 | 3 |
| PTP4A3 | LINC00608 | 0.706877 | 4 | 0 | 3 |
For details and further investigation, click here
