| Full name: prickle planar cell polarity protein 1 | Alias Symbol: FLJ31937|EPM1B|RILP | ||
| Type: protein-coding gene | Cytoband: 12q12 | ||
| Entrez ID: 144165 | HGNC ID: HGNC:17019 | Ensembl Gene: ENSG00000139174 | OMIM ID: 608500 |
| Drug and gene relationship at DGIdb | |||
PRICKLE1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of PRICKLE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRICKLE1 | 144165 | 226065_at | 0.6017 | 0.3734 | |
| GSE26886 | PRICKLE1 | 144165 | 226065_at | 0.6525 | 0.0110 | |
| GSE45670 | PRICKLE1 | 144165 | 226065_at | 0.0251 | 0.9650 | |
| GSE53622 | PRICKLE1 | 144165 | 19934 | 0.4643 | 0.0000 | |
| GSE53624 | PRICKLE1 | 144165 | 19934 | 0.7415 | 0.0000 | |
| GSE63941 | PRICKLE1 | 144165 | 226065_at | -0.9691 | 0.2219 | |
| GSE77861 | PRICKLE1 | 144165 | 226065_at | 1.0287 | 0.0184 | |
| GSE97050 | PRICKLE1 | 144165 | A_23_P408285 | -0.1124 | 0.6223 | |
| SRP007169 | PRICKLE1 | 144165 | RNAseq | 3.0626 | 0.0001 | |
| SRP008496 | PRICKLE1 | 144165 | RNAseq | 4.1258 | 0.0000 | |
| SRP064894 | PRICKLE1 | 144165 | RNAseq | 1.6113 | 0.0000 | |
| SRP133303 | PRICKLE1 | 144165 | RNAseq | 0.8639 | 0.0070 | |
| SRP159526 | PRICKLE1 | 144165 | RNAseq | 1.3649 | 0.0044 | |
| SRP193095 | PRICKLE1 | 144165 | RNAseq | 1.1725 | 0.0000 | |
| SRP219564 | PRICKLE1 | 144165 | RNAseq | 0.2312 | 0.8005 | |
| TCGA | PRICKLE1 | 144165 | RNAseq | 0.2873 | 0.0545 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by PRICKLE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRICKLE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRICKLE1 | 144165 | 4 | 1 | 25 | |
| GSE20123 | PRICKLE1 | 144165 | 4 | 1 | 25 | |
| GSE43470 | PRICKLE1 | 144165 | 4 | 3 | 36 | |
| GSE46452 | PRICKLE1 | 144165 | 8 | 1 | 50 | |
| GSE47630 | PRICKLE1 | 144165 | 11 | 2 | 27 | |
| GSE54993 | PRICKLE1 | 144165 | 0 | 7 | 63 | |
| GSE54994 | PRICKLE1 | 144165 | 7 | 2 | 44 | |
| GSE60625 | PRICKLE1 | 144165 | 0 | 0 | 11 | |
| GSE74703 | PRICKLE1 | 144165 | 3 | 2 | 31 | |
| GSE74704 | PRICKLE1 | 144165 | 2 | 1 | 17 | |
| TCGA | PRICKLE1 | 144165 | 16 | 15 | 65 |
Total number of gains: 59; Total number of losses: 35; Total Number of normals: 394.
Somatic mutations of PRICKLE1:
Generating mutation plots.
Highly correlated genes for PRICKLE1:
Showing top 20/767 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRICKLE1 | SMTN | 0.787217 | 3 | 0 | 3 |
| PRICKLE1 | FAM20B | 0.782184 | 3 | 0 | 3 |
| PRICKLE1 | SIX5 | 0.781414 | 3 | 0 | 3 |
| PRICKLE1 | IRF9 | 0.779455 | 3 | 0 | 3 |
| PRICKLE1 | IMPDH1 | 0.776769 | 3 | 0 | 3 |
| PRICKLE1 | TRADD | 0.771666 | 3 | 0 | 3 |
| PRICKLE1 | CEBPZ | 0.750014 | 3 | 0 | 3 |
| PRICKLE1 | KBTBD2 | 0.74253 | 3 | 0 | 3 |
| PRICKLE1 | AP3B2 | 0.739538 | 3 | 0 | 3 |
| PRICKLE1 | DNAH14 | 0.735419 | 3 | 0 | 3 |
| PRICKLE1 | ULK1 | 0.734892 | 3 | 0 | 3 |
| PRICKLE1 | UBXN7 | 0.731924 | 3 | 0 | 3 |
| PRICKLE1 | APLP2 | 0.727853 | 3 | 0 | 3 |
| PRICKLE1 | ZNF423 | 0.726021 | 3 | 0 | 3 |
| PRICKLE1 | HNRNPU | 0.72397 | 4 | 0 | 3 |
| PRICKLE1 | NGF | 0.719343 | 3 | 0 | 3 |
| PRICKLE1 | CHD1 | 0.71923 | 3 | 0 | 3 |
| PRICKLE1 | STK17A | 0.716891 | 4 | 0 | 3 |
| PRICKLE1 | FGFRL1 | 0.715704 | 3 | 0 | 3 |
| PRICKLE1 | GAS2L1 | 0.713041 | 3 | 0 | 3 |
For details and further investigation, click here
