GNAI2

 

Full name: G protein subunit alpha i2 Alias Symbol: GIP
Type: protein-coding gene Cytoband: 3p21.31
Entrez ID: 2771 HGNC ID: HGNC:4385 Ensembl Gene: ENSG00000114353 OMIM ID: 139360
Drug and gene relationship at DGIdb

 

GNAI2 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04360Axon guidance
hsa04540Gap junction
hsa04611Platelet activation
hsa04670Leukocyte transendothelial migration
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04924Renin secretion
hsa04971Gastric acid secretion
hsa05012Parkinson's disease
hsa05030Cocaine addiction
hsa05032Morphine addiction
hsa05034Alcoholism
hsa05133Pertussis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis

 

Expression of GNAI2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNAI2 2771 201040_at 0.1479 0.6514
GSE20347 GNAI2 2771 201040_at -0.0803 0.4542
GSE23400 GNAI2 2771 201040_at -0.0362 0.5848
GSE26886 GNAI2 2771 201040_at -0.6261 0.0171
GSE29001 GNAI2 2771 201040_at -0.1450 0.5869
GSE38129 GNAI2 2771 201040_at -0.2088 0.3826
GSE45670 GNAI2 2771 201040_at -0.0020 0.9877
GSE53622 GNAI2 2771 86603 -0.0209 0.7451
GSE53624 GNAI2 2771 86603 0.1776 0.0002
GSE63941 GNAI2 2771 201040_at 0.1236 0.8408
GSE77861 GNAI2 2771 201040_at 0.1526 0.4336
GSE97050 GNAI2 2771 A_33_P3585268 0.1965 0.4120
SRP007169 GNAI2 2771 RNAseq 0.1534 0.8123
SRP008496 GNAI2 2771 RNAseq 0.2784 0.4524
SRP064894 GNAI2 2771 RNAseq 0.3534 0.1093
SRP133303 GNAI2 2771 RNAseq 0.1836 0.2671
SRP159526 GNAI2 2771 RNAseq -0.1031 0.5012
SRP193095 GNAI2 2771 RNAseq 0.1351 0.3859
SRP219564 GNAI2 2771 RNAseq -0.1536 0.7222
TCGA GNAI2 2771 RNAseq 0.0396 0.3305

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by GNAI2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNAI2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNAI2 2771 0 18 12
GSE20123 GNAI2 2771 0 19 11
GSE43470 GNAI2 2771 0 19 24
GSE46452 GNAI2 2771 2 16 41
GSE47630 GNAI2 2771 1 24 15
GSE54993 GNAI2 2771 6 2 62
GSE54994 GNAI2 2771 1 33 19
GSE60625 GNAI2 2771 5 0 6
GSE74703 GNAI2 2771 0 15 21
GSE74704 GNAI2 2771 0 12 8
TCGA GNAI2 2771 0 78 18

Total number of gains: 15; Total number of losses: 236; Total Number of normals: 237.  

 

Somatic mutations of GNAI2:

 

Generating mutation plots.

 

Highly correlated genes for GNAI2:

 

Showing top 20/307 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNAI2TMEM2220.773955303
GNAI2SIX50.750345303
GNAI2TSPAN150.740332303
GNAI2RPTOR0.739533404
GNAI2SYMPK0.736998303
GNAI2DOCK60.734665303
GNAI2TAF150.723896303
GNAI2FIBCD10.719781303
GNAI2S1PR10.715652303
GNAI2CCDC88A0.712803403
GNAI2SYNGR20.709702404
GNAI2CTSZ0.708742303
GNAI2CCDC1240.707365303
GNAI2CLU0.695774303
GNAI2GLYR10.692686404
GNAI2ZMYM60.691696303
GNAI2RBMS20.687166303
GNAI2CDK5RAP30.686776303
GNAI2RERE0.67389303
GNAI2INTS30.673146505

For details and further investigation, click here