| Full name: transcription factor 7 like 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p11.2 | ||
| Entrez ID: 83439 | HGNC ID: HGNC:11640 | Ensembl Gene: ENSG00000152284 | OMIM ID: 604652 |
| Drug and gene relationship at DGIdb | |||
TCF7L1 involved pathways:
Expression of TCF7L1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TCF7L1 | 83439 | 221016_s_at | -0.3165 | 0.7372 | |
| GSE20347 | TCF7L1 | 83439 | 221016_s_at | 0.4927 | 0.0936 | |
| GSE23400 | TCF7L1 | 83439 | 221016_s_at | -0.1266 | 0.1727 | |
| GSE26886 | TCF7L1 | 83439 | 221016_s_at | 1.1685 | 0.0010 | |
| GSE29001 | TCF7L1 | 83439 | 221016_s_at | 0.8447 | 0.1490 | |
| GSE38129 | TCF7L1 | 83439 | 221016_s_at | 0.0235 | 0.9591 | |
| GSE45670 | TCF7L1 | 83439 | 221016_s_at | -0.4594 | 0.1613 | |
| GSE53622 | TCF7L1 | 83439 | 94618 | 0.3298 | 0.0360 | |
| GSE53624 | TCF7L1 | 83439 | 94618 | 0.3385 | 0.0062 | |
| GSE63941 | TCF7L1 | 83439 | 221016_s_at | -1.0193 | 0.2876 | |
| GSE77861 | TCF7L1 | 83439 | 221016_s_at | 0.4567 | 0.1506 | |
| GSE97050 | TCF7L1 | 83439 | A_23_P142872 | -0.3416 | 0.2816 | |
| SRP064894 | TCF7L1 | 83439 | RNAseq | 0.6319 | 0.0179 | |
| SRP133303 | TCF7L1 | 83439 | RNAseq | 0.2678 | 0.3305 | |
| SRP159526 | TCF7L1 | 83439 | RNAseq | 1.7934 | 0.0205 | |
| SRP193095 | TCF7L1 | 83439 | RNAseq | 1.1448 | 0.0000 | |
| SRP219564 | TCF7L1 | 83439 | RNAseq | -0.2811 | 0.6655 | |
| TCGA | TCF7L1 | 83439 | RNAseq | 0.1233 | 0.2581 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by TCF7L1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TCF7L1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TCF7L1 | 83439 | 9 | 2 | 19 | |
| GSE20123 | TCF7L1 | 83439 | 9 | 2 | 19 | |
| GSE43470 | TCF7L1 | 83439 | 6 | 2 | 35 | |
| GSE46452 | TCF7L1 | 83439 | 2 | 3 | 54 | |
| GSE47630 | TCF7L1 | 83439 | 7 | 0 | 33 | |
| GSE54993 | TCF7L1 | 83439 | 0 | 6 | 64 | |
| GSE54994 | TCF7L1 | 83439 | 10 | 0 | 43 | |
| GSE60625 | TCF7L1 | 83439 | 0 | 3 | 8 | |
| GSE74703 | TCF7L1 | 83439 | 5 | 1 | 30 | |
| GSE74704 | TCF7L1 | 83439 | 7 | 0 | 13 | |
| TCGA | TCF7L1 | 83439 | 35 | 4 | 57 |
Total number of gains: 90; Total number of losses: 23; Total Number of normals: 375.
Somatic mutations of TCF7L1:
Generating mutation plots.
Highly correlated genes for TCF7L1:
Showing top 20/1050 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TCF7L1 | TRIM47 | 0.814017 | 3 | 0 | 3 |
| TCF7L1 | NEK9 | 0.775399 | 5 | 0 | 4 |
| TCF7L1 | MSRB2 | 0.764056 | 3 | 0 | 3 |
| TCF7L1 | TMEM92 | 0.755318 | 3 | 0 | 3 |
| TCF7L1 | IGF2R | 0.748219 | 3 | 0 | 3 |
| TCF7L1 | SKI | 0.748084 | 3 | 0 | 3 |
| TCF7L1 | THEM4 | 0.747781 | 3 | 0 | 3 |
| TCF7L1 | INTS3 | 0.740994 | 4 | 0 | 4 |
| TCF7L1 | STRADA | 0.740183 | 3 | 0 | 3 |
| TCF7L1 | ERG | 0.737143 | 3 | 0 | 3 |
| TCF7L1 | KCND3 | 0.733074 | 3 | 0 | 3 |
| TCF7L1 | SIX5 | 0.732152 | 3 | 0 | 3 |
| TCF7L1 | DNAJC27 | 0.731751 | 3 | 0 | 3 |
| TCF7L1 | RAVER1 | 0.73089 | 3 | 0 | 3 |
| TCF7L1 | SGTB | 0.726958 | 3 | 0 | 3 |
| TCF7L1 | ZNF827 | 0.726085 | 4 | 0 | 4 |
| TCF7L1 | BHLHE41 | 0.720196 | 5 | 0 | 4 |
| TCF7L1 | BRAT1 | 0.718227 | 3 | 0 | 3 |
| TCF7L1 | SOCS5 | 0.715483 | 6 | 0 | 6 |
| TCF7L1 | DOCK5 | 0.714439 | 3 | 0 | 3 |
For details and further investigation, click here
