GNG3

 

Full name: G protein subunit gamma 3 Alias Symbol: 
Type: protein-coding gene Cytoband: 11q12.3
Entrez ID: 2785 HGNC ID: HGNC:4405 Ensembl Gene: ENSG00000162188 OMIM ID: 608941
Drug and gene relationship at DGIdb

 

GNG3 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa05032Morphine addiction
hsa05034Alcoholism

 

Expression of GNG3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNG3 2785 222005_s_at 0.0764 0.7547
GSE20347 GNG3 2785 222005_s_at 0.0191 0.8459
GSE23400 GNG3 2785 222005_s_at -0.1230 0.0003
GSE26886 GNG3 2785 222005_s_at 0.0350 0.8254
GSE29001 GNG3 2785 222005_s_at -0.1061 0.4091
GSE38129 GNG3 2785 222005_s_at -0.1398 0.0746
GSE45670 GNG3 2785 222005_s_at 0.0799 0.3275
GSE53622 GNG3 2785 20631 0.0244 0.8601
GSE53624 GNG3 2785 20631 0.5027 0.0000
GSE63941 GNG3 2785 222005_s_at 0.0894 0.6166
GSE77861 GNG3 2785 222005_s_at -0.0562 0.6317
GSE97050 GNG3 2785 A_23_P139192 -0.1718 0.5992
TCGA GNG3 2785 RNAseq -0.8012 0.0037

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by GNG3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNG3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNG3 2785 6 5 19
GSE20123 GNG3 2785 6 5 19
GSE43470 GNG3 2785 1 6 36
GSE46452 GNG3 2785 8 4 47
GSE47630 GNG3 2785 3 7 30
GSE54993 GNG3 2785 3 0 67
GSE54994 GNG3 2785 4 5 44
GSE60625 GNG3 2785 0 3 8
GSE74703 GNG3 2785 1 3 32
GSE74704 GNG3 2785 4 3 13
TCGA GNG3 2785 12 11 73

Total number of gains: 48; Total number of losses: 52; Total Number of normals: 388.  

 

Somatic mutations of GNG3:

 

Generating mutation plots.

 

Highly correlated genes for GNG3:

 

Showing top 20/725 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNG3CNTF0.797316303
GNG3CSF2RA0.745213303
GNG3SIX50.735742303
GNG3GBF10.72916303
GNG3IFT1220.726697404
GNG3SLC29A30.711359303
GNG3CHN20.706446303
GNG3RBP40.700039303
GNG3COLEC100.698723404
GNG3ZFYVE90.697019303
GNG3IFNA50.692569303
GNG3ITGB30.692142403
GNG3DNASE2B0.68869303
GNG3RPGRIP10.686864404
GNG3AMOTL20.685236303
GNG3CDC14A0.684857403
GNG3CA80.684584403
GNG3IFNA160.6786403
GNG3ZNF3340.677197303
GNG3GLI20.675984303

For details and further investigation, click here