SHC2

 

Full name: SHC adaptor protein 2 Alias Symbol: SLI|SCK|SHCB
Type: protein-coding gene Cytoband: 19p13.3
Entrez ID: 25759 HGNC ID: HGNC:29869 Ensembl Gene: ENSG00000129946 OMIM ID: 605217
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

SHC2 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04650Natural killer cell mediated cytotoxicity
hsa04722Neurotrophin signaling pathway
hsa04910Insulin signaling pathway
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa05214Glioma
hsa05220Chronic myeloid leukemia

 

Expression of SHC2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SHC2 25759 213464_at -0.1224 0.7803
GSE20347 SHC2 25759 213464_at 0.0512 0.6287
GSE23400 SHC2 25759 213464_at -0.0315 0.6263
GSE26886 SHC2 25759 213464_at 0.6961 0.0000
GSE29001 SHC2 25759 213464_at -0.2334 0.2695
GSE38129 SHC2 25759 213464_at -0.0910 0.5234
GSE45670 SHC2 25759 213464_at -0.1275 0.4053
GSE53622 SHC2 25759 97509 -0.0562 0.4620
GSE53624 SHC2 25759 97509 0.0592 0.5175
GSE63941 SHC2 25759 213464_at -0.3594 0.2540
GSE77861 SHC2 25759 213464_at 0.1194 0.5730
GSE97050 SHC2 25759 A_32_P205624 -0.1425 0.5530
SRP007169 SHC2 25759 RNAseq 0.4344 0.5546
SRP064894 SHC2 25759 RNAseq 0.8302 0.0466
SRP133303 SHC2 25759 RNAseq -0.5011 0.0898
SRP159526 SHC2 25759 RNAseq 0.1248 0.7241
SRP193095 SHC2 25759 RNAseq 0.6007 0.0871
SRP219564 SHC2 25759 RNAseq 0.3752 0.5322
TCGA SHC2 25759 RNAseq -0.6834 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SHC2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SHC2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SHC2 25759 6 6 18
GSE20123 SHC2 25759 6 5 19
GSE43470 SHC2 25759 1 10 32
GSE46452 SHC2 25759 47 1 11
GSE47630 SHC2 25759 5 7 28
GSE54993 SHC2 25759 13 4 53
GSE54994 SHC2 25759 8 15 30
GSE60625 SHC2 25759 9 0 2
GSE74703 SHC2 25759 1 7 28
GSE74704 SHC2 25759 5 3 12
TCGA SHC2 25759 8 25 63

Total number of gains: 109; Total number of losses: 83; Total Number of normals: 296.  

 

Somatic mutations of SHC2:

 

Generating mutation plots.

 

Highly correlated genes for SHC2:

 

Showing top 20/433 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SHC2GTF2IRD20.811857303
SHC2TREM10.781448303
SHC2USH1C0.777372303
SHC2ZMYND150.777083303
SHC2STAC30.763732303
SHC2SHISA70.763694303
SHC2OLIG30.761131303
SHC2CHRND0.752197303
SHC2SHISA40.748447404
SHC2SLC10A10.741232303
SHC2ZNF5270.732646404
SHC2BMP8B0.730986303
SHC2CACNG40.728888404
SHC2HCRTR10.727399303
SHC2EDA0.727067505
SHC2MOGAT30.722394303
SHC2ZBTB240.716192303
SHC2ADCY10.715395303
SHC2ABCA40.711666303
SHC2U2AF1L40.705271404

For details and further investigation, click here