| Full name: solute carrier family 22 member 8 | Alias Symbol: OAT3 | ||
| Type: protein-coding gene | Cytoband: 11q12.3 | ||
| Entrez ID: 9376 | HGNC ID: HGNC:10972 | Ensembl Gene: ENSG00000149452 | OMIM ID: 607581 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC22A8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC22A8 | 9376 | 231352_at | -0.2493 | 0.2663 | |
| GSE20347 | SLC22A8 | 9376 | 221298_s_at | -0.2236 | 0.0095 | |
| GSE23400 | SLC22A8 | 9376 | 221298_s_at | -0.0442 | 0.3256 | |
| GSE26886 | SLC22A8 | 9376 | 221298_s_at | -0.2579 | 0.3008 | |
| GSE29001 | SLC22A8 | 9376 | 221298_s_at | -0.2282 | 0.1382 | |
| GSE38129 | SLC22A8 | 9376 | 221298_s_at | -0.2304 | 0.0384 | |
| GSE45670 | SLC22A8 | 9376 | 221298_s_at | 0.1828 | 0.1857 | |
| GSE53622 | SLC22A8 | 9376 | 12680 | 0.0839 | 0.3869 | |
| GSE53624 | SLC22A8 | 9376 | 12680 | 0.0780 | 0.3465 | |
| GSE63941 | SLC22A8 | 9376 | 231352_at | 0.3787 | 0.0164 | |
| GSE77861 | SLC22A8 | 9376 | 221298_s_at | -0.1158 | 0.3721 | |
| GSE97050 | SLC22A8 | 9376 | A_33_P3367171 | 0.0510 | 0.8255 | |
| TCGA | SLC22A8 | 9376 | RNAseq | -2.3749 | 0.0489 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SLC22A8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC22A8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC22A8 | 9376 | 6 | 5 | 19 | |
| GSE20123 | SLC22A8 | 9376 | 6 | 4 | 20 | |
| GSE43470 | SLC22A8 | 9376 | 1 | 6 | 36 | |
| GSE46452 | SLC22A8 | 9376 | 8 | 4 | 47 | |
| GSE47630 | SLC22A8 | 9376 | 3 | 7 | 30 | |
| GSE54993 | SLC22A8 | 9376 | 3 | 0 | 67 | |
| GSE54994 | SLC22A8 | 9376 | 5 | 5 | 43 | |
| GSE60625 | SLC22A8 | 9376 | 0 | 3 | 8 | |
| GSE74703 | SLC22A8 | 9376 | 1 | 3 | 32 | |
| GSE74704 | SLC22A8 | 9376 | 4 | 3 | 13 | |
| TCGA | SLC22A8 | 9376 | 17 | 11 | 68 |
Total number of gains: 54; Total number of losses: 51; Total Number of normals: 383.
Somatic mutations of SLC22A8:
Generating mutation plots.
Highly correlated genes for SLC22A8:
Showing top 20/1152 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC22A8 | YY2 | 0.817799 | 3 | 0 | 3 |
| SLC22A8 | PRSS38 | 0.814193 | 3 | 0 | 3 |
| SLC22A8 | STRC | 0.803353 | 3 | 0 | 3 |
| SLC22A8 | PABPN1L | 0.792554 | 3 | 0 | 3 |
| SLC22A8 | MRGPRG | 0.790407 | 3 | 0 | 3 |
| SLC22A8 | CTSE | 0.789776 | 3 | 0 | 3 |
| SLC22A8 | DCDC1 | 0.782373 | 3 | 0 | 3 |
| SLC22A8 | C9orf153 | 0.778742 | 3 | 0 | 3 |
| SLC22A8 | LHB | 0.77531 | 3 | 0 | 3 |
| SLC22A8 | C1QL2 | 0.772551 | 3 | 0 | 3 |
| SLC22A8 | C19orf71 | 0.769901 | 3 | 0 | 3 |
| SLC22A8 | PLA2G2C | 0.764509 | 3 | 0 | 3 |
| SLC22A8 | LIME1 | 0.762401 | 3 | 0 | 3 |
| SLC22A8 | BSX | 0.762038 | 3 | 0 | 3 |
| SLC22A8 | OR2B11 | 0.760271 | 3 | 0 | 3 |
| SLC22A8 | LRRC3C | 0.759968 | 3 | 0 | 3 |
| SLC22A8 | OR10AD1 | 0.75583 | 3 | 0 | 3 |
| SLC22A8 | TUBA3D | 0.748073 | 3 | 0 | 3 |
| SLC22A8 | OR2T27 | 0.747241 | 3 | 0 | 3 |
| SLC22A8 | BBC3 | 0.747008 | 3 | 0 | 3 |
For details and further investigation, click here
