| Full name: solute carrier family 5 member 5 | Alias Symbol: NIS | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 6528 | HGNC ID: HGNC:11040 | Ensembl Gene: ENSG00000105641 | OMIM ID: 601843 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC5A5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC5A5 | 6528 | 211123_at | 0.0196 | 0.9615 | |
| GSE20347 | SLC5A5 | 6528 | 211123_at | -0.0562 | 0.5353 | |
| GSE23400 | SLC5A5 | 6528 | 211123_at | -0.1268 | 0.0012 | |
| GSE26886 | SLC5A5 | 6528 | 211123_at | 0.0631 | 0.7391 | |
| GSE29001 | SLC5A5 | 6528 | 211123_at | -0.1836 | 0.3802 | |
| GSE38129 | SLC5A5 | 6528 | 211123_at | -0.1217 | 0.1154 | |
| GSE45670 | SLC5A5 | 6528 | 211123_at | 0.0548 | 0.5899 | |
| GSE53622 | SLC5A5 | 6528 | 56098 | 0.0679 | 0.7292 | |
| GSE53624 | SLC5A5 | 6528 | 56098 | 0.0791 | 0.5598 | |
| GSE63941 | SLC5A5 | 6528 | 211123_at | 0.1398 | 0.3876 | |
| GSE77861 | SLC5A5 | 6528 | 211123_at | -0.0336 | 0.7730 | |
| GSE97050 | SLC5A5 | 6528 | A_23_P101774 | 0.3258 | 0.1994 | |
| SRP133303 | SLC5A5 | 6528 | RNAseq | 0.1010 | 0.6630 | |
| TCGA | SLC5A5 | 6528 | RNAseq | -3.4848 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SLC5A5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC5A5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC5A5 | 6528 | 4 | 4 | 22 | |
| GSE20123 | SLC5A5 | 6528 | 3 | 2 | 25 | |
| GSE43470 | SLC5A5 | 6528 | 2 | 6 | 35 | |
| GSE46452 | SLC5A5 | 6528 | 47 | 1 | 11 | |
| GSE47630 | SLC5A5 | 6528 | 4 | 8 | 28 | |
| GSE54993 | SLC5A5 | 6528 | 15 | 4 | 51 | |
| GSE54994 | SLC5A5 | 6528 | 6 | 14 | 33 | |
| GSE60625 | SLC5A5 | 6528 | 9 | 0 | 2 | |
| GSE74703 | SLC5A5 | 6528 | 2 | 4 | 30 | |
| GSE74704 | SLC5A5 | 6528 | 0 | 2 | 18 | |
| TCGA | SLC5A5 | 6528 | 17 | 9 | 70 |
Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.
Somatic mutations of SLC5A5:
Generating mutation plots.
Highly correlated genes for SLC5A5:
Showing top 20/1248 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC5A5 | POU1F1 | 0.802313 | 3 | 0 | 3 |
| SLC5A5 | C10orf91 | 0.797787 | 3 | 0 | 3 |
| SLC5A5 | SCLY | 0.780541 | 3 | 0 | 3 |
| SLC5A5 | TMEM229A | 0.776282 | 3 | 0 | 3 |
| SLC5A5 | C1QTNF1 | 0.754374 | 3 | 0 | 3 |
| SLC5A5 | REG3A | 0.749757 | 5 | 0 | 5 |
| SLC5A5 | FUT7 | 0.747887 | 3 | 0 | 3 |
| SLC5A5 | LRRC71 | 0.747386 | 3 | 0 | 3 |
| SLC5A5 | MAGEA8 | 0.744315 | 3 | 0 | 3 |
| SLC5A5 | CLCNKA | 0.742921 | 3 | 0 | 3 |
| SLC5A5 | IL1RAPL2 | 0.741467 | 4 | 0 | 4 |
| SLC5A5 | PNPLA7 | 0.732057 | 3 | 0 | 3 |
| SLC5A5 | RAI1 | 0.731056 | 5 | 0 | 5 |
| SLC5A5 | RNF17 | 0.724853 | 5 | 0 | 5 |
| SLC5A5 | GPHB5 | 0.719816 | 4 | 0 | 3 |
| SLC5A5 | IL9R | 0.719325 | 7 | 0 | 6 |
| SLC5A5 | OR7C2 | 0.718573 | 4 | 0 | 4 |
| SLC5A5 | NOS3 | 0.717945 | 4 | 0 | 4 |
| SLC5A5 | SHANK1 | 0.717527 | 4 | 0 | 4 |
| SLC5A5 | PHF7 | 0.716388 | 6 | 0 | 5 |
For details and further investigation, click here
