NOS3

 

Full name: nitric oxide synthase 3 Alias Symbol: ECNOS|eNOS
Type: protein-coding gene Cytoband: 7q36.1
Entrez ID: 4846 HGNC ID: HGNC:7876 Ensembl Gene: ENSG00000164867 OMIM ID: 163729
Drug and gene relationship at DGIdb

 

NOS3 involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04066HIF-1 signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04370VEGF signaling pathway
hsa04611Platelet activation
hsa04915Estrogen signaling pathway
hsa04921Oxytocin signaling pathway
hsa04931Insulin resistance
hsa04933AGE-RAGE signaling pathway in diabetic complications

 

Expression of NOS3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NOS3 4846 205581_s_at 0.1587 0.7322
GSE20347 NOS3 4846 205581_s_at -0.0374 0.7162
GSE23400 NOS3 4846 205581_s_at -0.0608 0.0813
GSE26886 NOS3 4846 205581_s_at 0.1575 0.2440
GSE29001 NOS3 4846 205581_s_at 0.0215 0.9103
GSE38129 NOS3 4846 205581_s_at -0.0139 0.9064
GSE45670 NOS3 4846 205581_s_at -0.0334 0.8570
GSE53622 NOS3 4846 69924 -0.0682 0.4782
GSE53624 NOS3 4846 69924 -0.1095 0.1161
GSE63941 NOS3 4846 205581_s_at 0.0634 0.7987
GSE77861 NOS3 4846 205581_s_at 0.0401 0.7317
GSE97050 NOS3 4846 A_33_P3305790 0.3446 0.2642
SRP007169 NOS3 4846 RNAseq 0.6427 0.3859
SRP064894 NOS3 4846 RNAseq -1.6054 0.0000
SRP133303 NOS3 4846 RNAseq -0.7734 0.0000
SRP159526 NOS3 4846 RNAseq -0.6987 0.1069
SRP193095 NOS3 4846 RNAseq -0.3765 0.0051
SRP219564 NOS3 4846 RNAseq -1.5369 0.0000
TCGA NOS3 4846 RNAseq -0.4102 0.0004

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by NOS3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NOS3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NOS3 4846 2 4 24
GSE20123 NOS3 4846 2 4 24
GSE43470 NOS3 4846 2 5 36
GSE46452 NOS3 4846 7 2 50
GSE47630 NOS3 4846 5 9 26
GSE54993 NOS3 4846 3 3 64
GSE54994 NOS3 4846 5 8 40
GSE60625 NOS3 4846 0 0 11
GSE74703 NOS3 4846 2 4 30
GSE74704 NOS3 4846 1 4 15
TCGA NOS3 4846 26 26 44

Total number of gains: 55; Total number of losses: 69; Total Number of normals: 364.  

 

Somatic mutations of NOS3:

 

Generating mutation plots.

 

Highly correlated genes for NOS3:

 

Showing top 20/277 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NOS3CCL260.771997303
NOS3SLC5A50.717945404
NOS3FOXA20.710886404
NOS3CALCA0.710753303
NOS3DUSP90.689644303
NOS3LGALS120.688551303
NOS3ABCC20.685601404
NOS3LCN10.681136303
NOS3GPHB50.679677403
NOS3MYLK30.677374303
NOS3DNAI10.676927303
NOS3KIR3DL30.676286303
NOS3WDR600.67486303
NOS3C20orf850.670715303
NOS3AICDA0.668692303
NOS3TOR2A0.662207404
NOS3SLC6A30.661961404
NOS3CCL270.661018404
NOS3CCDC330.657751303
NOS3MPPED10.65627303

For details and further investigation, click here