| Full name: solute carrier family 6 member 2 | Alias Symbol: NET | ||
| Type: protein-coding gene | Cytoband: 16q12.2 | ||
| Entrez ID: 6530 | HGNC ID: HGNC:11048 | Ensembl Gene: ENSG00000103546 | OMIM ID: 163970 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC6A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC6A2 | 6530 | 216611_s_at | 0.0189 | 0.9744 | |
| GSE20347 | SLC6A2 | 6530 | 216611_s_at | -0.1028 | 0.1906 | |
| GSE23400 | SLC6A2 | 6530 | 215715_at | 0.2354 | 0.0002 | |
| GSE26886 | SLC6A2 | 6530 | 216611_s_at | 0.1865 | 0.2661 | |
| GSE29001 | SLC6A2 | 6530 | 215715_at | 1.4309 | 0.0253 | |
| GSE38129 | SLC6A2 | 6530 | 216611_s_at | -0.2017 | 0.1842 | |
| GSE45670 | SLC6A2 | 6530 | 216611_s_at | -0.1973 | 0.2032 | |
| GSE53622 | SLC6A2 | 6530 | 70038 | 0.8914 | 0.0000 | |
| GSE53624 | SLC6A2 | 6530 | 70038 | 0.9298 | 0.0000 | |
| GSE63941 | SLC6A2 | 6530 | 216611_s_at | 0.1419 | 0.3740 | |
| GSE77861 | SLC6A2 | 6530 | 216611_s_at | -0.0697 | 0.7265 | |
| GSE97050 | SLC6A2 | 6530 | A_33_P3259022 | 0.3737 | 0.2286 | |
| SRP007169 | SLC6A2 | 6530 | RNAseq | 3.8471 | 0.0016 | |
| SRP219564 | SLC6A2 | 6530 | RNAseq | 3.5022 | 0.0000 | |
| TCGA | SLC6A2 | 6530 | RNAseq | 1.8187 | 0.0002 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by SLC6A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC6A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC6A2 | 6530 | 4 | 0 | 26 | |
| GSE20123 | SLC6A2 | 6530 | 4 | 0 | 26 | |
| GSE43470 | SLC6A2 | 6530 | 2 | 7 | 34 | |
| GSE46452 | SLC6A2 | 6530 | 38 | 1 | 20 | |
| GSE47630 | SLC6A2 | 6530 | 10 | 8 | 22 | |
| GSE54993 | SLC6A2 | 6530 | 2 | 4 | 64 | |
| GSE54994 | SLC6A2 | 6530 | 7 | 10 | 36 | |
| GSE60625 | SLC6A2 | 6530 | 4 | 0 | 7 | |
| GSE74703 | SLC6A2 | 6530 | 2 | 4 | 30 | |
| GSE74704 | SLC6A2 | 6530 | 3 | 0 | 17 | |
| TCGA | SLC6A2 | 6530 | 25 | 12 | 59 |
Total number of gains: 101; Total number of losses: 46; Total Number of normals: 341.
Somatic mutations of SLC6A2:
Generating mutation plots.
Highly correlated genes for SLC6A2:
Showing top 20/246 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC6A2 | ANKRD9 | 0.835436 | 3 | 0 | 3 |
| SLC6A2 | OR2AT4 | 0.775143 | 3 | 0 | 3 |
| SLC6A2 | OR2T12 | 0.745608 | 3 | 0 | 3 |
| SLC6A2 | CDH24 | 0.741099 | 4 | 0 | 4 |
| SLC6A2 | SZT2 | 0.740991 | 3 | 0 | 3 |
| SLC6A2 | OR2T33 | 0.737026 | 3 | 0 | 3 |
| SLC6A2 | SLC26A5 | 0.734978 | 3 | 0 | 3 |
| SLC6A2 | ALG11 | 0.716953 | 3 | 0 | 3 |
| SLC6A2 | LINC00475 | 0.713303 | 3 | 0 | 3 |
| SLC6A2 | APOB | 0.709617 | 3 | 0 | 3 |
| SLC6A2 | CDRT15L2 | 0.704459 | 3 | 0 | 3 |
| SLC6A2 | ZNF445 | 0.70019 | 3 | 0 | 3 |
| SLC6A2 | GRIA4 | 0.698671 | 3 | 0 | 3 |
| SLC6A2 | STARD7-AS1 | 0.695975 | 4 | 0 | 4 |
| SLC6A2 | DDOST | 0.69552 | 3 | 0 | 3 |
| SLC6A2 | DPP3 | 0.695135 | 3 | 0 | 3 |
| SLC6A2 | ARTN | 0.694824 | 4 | 0 | 3 |
| SLC6A2 | MRPS25 | 0.691065 | 3 | 0 | 3 |
| SLC6A2 | PAWR | 0.690437 | 3 | 0 | 3 |
| SLC6A2 | CCDC144A | 0.690338 | 3 | 0 | 3 |
For details and further investigation, click here
