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File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
Line: 123
Function: exec

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
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Function: drawSurvPlot

File: /data/webapp/var/www/html/ESCCdb/index.php
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Function: require_once

Multi-Omics Database of ESCC

 

MRPS25

 

Full name: mitochondrial ribosomal protein S25 Alias Symbol: MRP-S25|FLJ00023|DKFZp313H0817|RPMS25
Type: protein-coding gene Cytoband: 3p25.1
Entrez ID: 64432 HGNC ID: HGNC:14511 Ensembl Gene: ENSG00000131368 OMIM ID: 611987
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of MRPS25:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MRPS25 64432 224869_s_at -0.1387 0.6386
GSE26886 MRPS25 64432 224869_s_at -0.1939 0.2107
GSE45670 MRPS25 64432 224869_s_at 0.1160 0.3099
GSE63941 MRPS25 64432 224869_s_at 0.2952 0.2519
GSE77861 MRPS25 64432 224869_s_at -0.2493 0.2868
GSE97050 MRPS25 64432 A_33_P3266444 0.0410 0.8956
SRP007169 MRPS25 64432 RNAseq 0.0197 0.9606
SRP008496 MRPS25 64432 RNAseq 0.3233 0.3979
SRP064894 MRPS25 64432 RNAseq -0.1231 0.4961
SRP133303 MRPS25 64432 RNAseq -0.4777 0.0174
SRP159526 MRPS25 64432 RNAseq -0.5838 0.0051
SRP193095 MRPS25 64432 RNAseq -0.4277 0.0002
SRP219564 MRPS25 64432 RNAseq -0.3870 0.3360
TCGA MRPS25 64432 RNAseq -0.2612 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by MRPS25 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of MRPS25:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MRPS25 64432 1 19 10
GSE20123 MRPS25 64432 1 19 10
GSE43470 MRPS25 64432 0 21 22
GSE46452 MRPS25 64432 2 17 40
GSE47630 MRPS25 64432 2 23 15
GSE54993 MRPS25 64432 6 1 63
GSE54994 MRPS25 64432 1 32 20
GSE60625 MRPS25 64432 5 0 6
GSE74703 MRPS25 64432 0 17 19
GSE74704 MRPS25 64432 1 12 7
TCGA MRPS25 64432 2 68 26

Total number of gains: 21; Total number of losses: 229; Total Number of normals: 238.  

 

Somatic mutations of MRPS25:

 

Generating mutation plots.

 

Highly correlated genes for MRPS25:

 

Showing top 20/71 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MRPS25DIMT10.811706303
MRPS25ANO100.796095303
MRPS25MRPL390.791583303
MRPS25RPL140.732586303
MRPS25ACSL30.717013303
MRPS25TUBB2A0.709753303
MRPS25PPP2R5E0.706725303
MRPS25PDCD40.703939303
MRPS25RPS110.700261303
MRPS25CAPN30.69964303
MRPS25HMGCS10.699527303
MRPS25MTPN0.699045303
MRPS25OGFOD10.696012303
MRPS25SLC6A20.691065303
MRPS25RPL27A0.687361403
MRPS25USP190.68682303
MRPS25SIN3A0.682398303
MRPS25C9orf850.678496303
MRPS25GRPEL10.677485403
MRPS25UBE2E20.676794403

For details and further investigation, click here