| Full name: apolipoprotein B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p24.1 | ||
| Entrez ID: 338 | HGNC ID: HGNC:603 | Ensembl Gene: ENSG00000084674 | OMIM ID: 107730 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of APOB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APOB | 338 | 223579_s_at | -0.3291 | 0.1862 | |
| GSE20347 | APOB | 338 | 205108_s_at | -0.0538 | 0.5116 | |
| GSE23400 | APOB | 338 | 205108_s_at | -0.1499 | 0.0004 | |
| GSE26886 | APOB | 338 | 223579_s_at | -0.4973 | 0.0002 | |
| GSE29001 | APOB | 338 | 205108_s_at | -0.0081 | 0.9669 | |
| GSE38129 | APOB | 338 | 205108_s_at | -0.3420 | 0.0008 | |
| GSE45670 | APOB | 338 | 223579_s_at | -0.0409 | 0.7901 | |
| GSE53622 | APOB | 338 | 101898 | 0.1371 | 0.3438 | |
| GSE53624 | APOB | 338 | 101898 | 0.0317 | 0.8655 | |
| GSE63941 | APOB | 338 | 223579_s_at | 0.0290 | 0.8455 | |
| GSE77861 | APOB | 338 | 223579_s_at | -0.2366 | 0.0292 | |
| GSE97050 | APOB | 338 | A_33_P3267420 | -0.0502 | 0.8345 | |
| SRP133303 | APOB | 338 | RNAseq | -1.7159 | 0.0171 | |
| TCGA | APOB | 338 | RNAseq | -1.7172 | 0.0028 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by APOB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APOB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APOB | 338 | 10 | 1 | 19 | |
| GSE20123 | APOB | 338 | 10 | 1 | 19 | |
| GSE43470 | APOB | 338 | 2 | 0 | 41 | |
| GSE46452 | APOB | 338 | 3 | 4 | 52 | |
| GSE47630 | APOB | 338 | 7 | 0 | 33 | |
| GSE54993 | APOB | 338 | 0 | 7 | 63 | |
| GSE54994 | APOB | 338 | 11 | 0 | 42 | |
| GSE60625 | APOB | 338 | 0 | 3 | 8 | |
| GSE74703 | APOB | 338 | 2 | 0 | 34 | |
| GSE74704 | APOB | 338 | 9 | 1 | 10 | |
| TCGA | APOB | 338 | 35 | 2 | 59 |
Total number of gains: 89; Total number of losses: 19; Total Number of normals: 380.
Somatic mutations of APOB:
Generating mutation plots.
Highly correlated genes for APOB:
Showing top 20/1041 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APOB | SETBP1 | 0.805146 | 3 | 0 | 3 |
| APOB | FGF7 | 0.791635 | 3 | 0 | 3 |
| APOB | OR2T33 | 0.785493 | 3 | 0 | 3 |
| APOB | MBOAT2 | 0.783595 | 3 | 0 | 3 |
| APOB | KIR3DL2 | 0.78134 | 3 | 0 | 3 |
| APOB | CGGBP1 | 0.779498 | 3 | 0 | 3 |
| APOB | ITPKC | 0.778478 | 4 | 0 | 4 |
| APOB | ARHGEF6 | 0.776948 | 4 | 0 | 4 |
| APOB | CLTB | 0.77459 | 4 | 0 | 4 |
| APOB | KRTAP19-2 | 0.773767 | 3 | 0 | 3 |
| APOB | PRSS36 | 0.77371 | 3 | 0 | 3 |
| APOB | OLFML1 | 0.769921 | 3 | 0 | 3 |
| APOB | DYNC1I2 | 0.76811 | 3 | 0 | 3 |
| APOB | KLF2 | 0.766449 | 3 | 0 | 3 |
| APOB | OR2AT4 | 0.765048 | 3 | 0 | 3 |
| APOB | SPEG | 0.76413 | 3 | 0 | 3 |
| APOB | SLC26A5 | 0.760989 | 3 | 0 | 3 |
| APOB | ACAA1 | 0.754545 | 4 | 0 | 4 |
| APOB | MOB4 | 0.752127 | 3 | 0 | 3 |
| APOB | UBAP1 | 0.745331 | 5 | 0 | 4 |
For details and further investigation, click here
