| Full name: dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit | Alias Symbol: OST|KIAA0115|OST48|WBP1|GATD6 | ||
| Type: protein-coding gene | Cytoband: 1p36.12 | ||
| Entrez ID: 1650 | HGNC ID: HGNC:2728 | Ensembl Gene: ENSG00000244038 | OMIM ID: 602202 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DDOST:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDOST | 1650 | 208675_s_at | 0.6611 | 0.1410 | |
| GSE20347 | DDOST | 1650 | 208675_s_at | 0.3803 | 0.0349 | |
| GSE23400 | DDOST | 1650 | 208675_s_at | 0.5829 | 0.0000 | |
| GSE26886 | DDOST | 1650 | 208674_x_at | 0.5744 | 0.0142 | |
| GSE29001 | DDOST | 1650 | 208674_x_at | 0.3409 | 0.0393 | |
| GSE38129 | DDOST | 1650 | 208675_s_at | 0.5990 | 0.0000 | |
| GSE45670 | DDOST | 1650 | 208674_x_at | 0.4586 | 0.0007 | |
| GSE53622 | DDOST | 1650 | 4771 | 0.5385 | 0.0000 | |
| GSE53624 | DDOST | 1650 | 4771 | 0.4693 | 0.0000 | |
| GSE63941 | DDOST | 1650 | 208675_s_at | 1.5053 | 0.0003 | |
| GSE77861 | DDOST | 1650 | 208675_s_at | 0.1268 | 0.6474 | |
| GSE97050 | DDOST | 1650 | A_23_P149099 | 0.4828 | 0.2261 | |
| SRP007169 | DDOST | 1650 | RNAseq | -0.2466 | 0.5797 | |
| SRP008496 | DDOST | 1650 | RNAseq | -0.2989 | 0.2116 | |
| SRP064894 | DDOST | 1650 | RNAseq | 0.8298 | 0.0000 | |
| SRP133303 | DDOST | 1650 | RNAseq | 0.6341 | 0.0000 | |
| SRP159526 | DDOST | 1650 | RNAseq | 0.5605 | 0.0059 | |
| SRP193095 | DDOST | 1650 | RNAseq | 0.2485 | 0.0901 | |
| SRP219564 | DDOST | 1650 | RNAseq | 0.4546 | 0.1044 | |
| TCGA | DDOST | 1650 | RNAseq | 0.0411 | 0.3177 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DDOST expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDOST:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDOST | 1650 | 0 | 5 | 25 | |
| GSE20123 | DDOST | 1650 | 0 | 4 | 26 | |
| GSE43470 | DDOST | 1650 | 0 | 8 | 35 | |
| GSE46452 | DDOST | 1650 | 5 | 1 | 53 | |
| GSE47630 | DDOST | 1650 | 8 | 3 | 29 | |
| GSE54993 | DDOST | 1650 | 3 | 1 | 66 | |
| GSE54994 | DDOST | 1650 | 11 | 4 | 38 | |
| GSE60625 | DDOST | 1650 | 0 | 0 | 11 | |
| GSE74703 | DDOST | 1650 | 0 | 5 | 31 | |
| GSE74704 | DDOST | 1650 | 0 | 0 | 20 | |
| TCGA | DDOST | 1650 | 10 | 22 | 64 |
Total number of gains: 37; Total number of losses: 53; Total Number of normals: 398.
Somatic mutations of DDOST:
Generating mutation plots.
Highly correlated genes for DDOST:
Showing top 20/1649 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDOST | POLDIP2 | 0.764902 | 3 | 0 | 3 |
| DDOST | KTI12 | 0.757768 | 3 | 0 | 3 |
| DDOST | INTS10 | 0.757758 | 3 | 0 | 3 |
| DDOST | ZBTB9 | 0.757737 | 4 | 0 | 4 |
| DDOST | SLC25A29 | 0.752745 | 3 | 0 | 3 |
| DDOST | PLEKHH1 | 0.747473 | 3 | 0 | 3 |
| DDOST | EMC1 | 0.737032 | 10 | 0 | 10 |
| DDOST | TSEN54 | 0.735549 | 3 | 0 | 3 |
| DDOST | MTHFD1L | 0.731967 | 3 | 0 | 3 |
| DDOST | SORL1 | 0.731618 | 3 | 0 | 3 |
| DDOST | ATXN7L3 | 0.726188 | 3 | 0 | 3 |
| DDOST | SLC35B2 | 0.725669 | 3 | 0 | 3 |
| DDOST | TMEM209 | 0.725141 | 5 | 0 | 5 |
| DDOST | PDIA6 | 0.719799 | 10 | 0 | 10 |
| DDOST | PDIA5 | 0.718889 | 3 | 0 | 3 |
| DDOST | PPIL1 | 0.712687 | 6 | 0 | 6 |
| DDOST | TRIM59 | 0.709553 | 3 | 0 | 3 |
| DDOST | EIF5A | 0.708723 | 3 | 0 | 3 |
| DDOST | RRNAD1 | 0.705771 | 3 | 0 | 3 |
| DDOST | RPRD1B | 0.703067 | 3 | 0 | 3 |
For details and further investigation, click here
