| Full name: pro-apoptotic WT1 regulator | Alias Symbol: par-4|PAR4 | ||
| Type: protein-coding gene | Cytoband: 12q21.2 | ||
| Entrez ID: 5074 | HGNC ID: HGNC:8614 | Ensembl Gene: ENSG00000177425 | OMIM ID: 601936 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PAWR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAWR | 5074 | 226223_at | -0.0854 | 0.9011 | |
| GSE20347 | PAWR | 5074 | 204004_at | 0.1469 | 0.3909 | |
| GSE23400 | PAWR | 5074 | 204004_at | 0.4242 | 0.0001 | |
| GSE26886 | PAWR | 5074 | 226223_at | 0.2667 | 0.1253 | |
| GSE29001 | PAWR | 5074 | 204004_at | 0.1433 | 0.7565 | |
| GSE38129 | PAWR | 5074 | 204004_at | 0.1262 | 0.6327 | |
| GSE45670 | PAWR | 5074 | 226223_at | -0.3023 | 0.1259 | |
| GSE53622 | PAWR | 5074 | 56808 | 0.2200 | 0.0060 | |
| GSE53624 | PAWR | 5074 | 56808 | 0.2461 | 0.0071 | |
| GSE63941 | PAWR | 5074 | 226223_at | 0.4362 | 0.5489 | |
| GSE77861 | PAWR | 5074 | 204004_at | 0.7149 | 0.1001 | |
| GSE97050 | PAWR | 5074 | A_23_P53663 | 0.2505 | 0.6339 | |
| SRP007169 | PAWR | 5074 | RNAseq | -0.2438 | 0.5737 | |
| SRP008496 | PAWR | 5074 | RNAseq | 0.0398 | 0.8924 | |
| SRP064894 | PAWR | 5074 | RNAseq | -0.1576 | 0.4882 | |
| SRP133303 | PAWR | 5074 | RNAseq | 0.3614 | 0.0769 | |
| SRP159526 | PAWR | 5074 | RNAseq | -0.2113 | 0.5042 | |
| SRP193095 | PAWR | 5074 | RNAseq | 0.3177 | 0.0096 | |
| SRP219564 | PAWR | 5074 | RNAseq | -0.5122 | 0.0616 | |
| TCGA | PAWR | 5074 | RNAseq | 0.2807 | 0.0010 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PAWR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAWR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAWR | 5074 | 4 | 3 | 23 | |
| GSE20123 | PAWR | 5074 | 4 | 3 | 23 | |
| GSE43470 | PAWR | 5074 | 3 | 1 | 39 | |
| GSE46452 | PAWR | 5074 | 8 | 1 | 50 | |
| GSE47630 | PAWR | 5074 | 10 | 1 | 29 | |
| GSE54993 | PAWR | 5074 | 0 | 5 | 65 | |
| GSE54994 | PAWR | 5074 | 7 | 1 | 45 | |
| GSE60625 | PAWR | 5074 | 0 | 0 | 11 | |
| GSE74703 | PAWR | 5074 | 3 | 1 | 32 | |
| GSE74704 | PAWR | 5074 | 2 | 2 | 16 | |
| TCGA | PAWR | 5074 | 15 | 14 | 67 |
Total number of gains: 56; Total number of losses: 32; Total Number of normals: 400.
Somatic mutations of PAWR:
Generating mutation plots.
Highly correlated genes for PAWR:
Showing top 20/204 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAWR | ZNF12 | 0.849888 | 3 | 0 | 3 |
| PAWR | DOCK7 | 0.723872 | 3 | 0 | 3 |
| PAWR | CIB1 | 0.71984 | 3 | 0 | 3 |
| PAWR | WDR92 | 0.708847 | 3 | 0 | 3 |
| PAWR | PARG | 0.694053 | 3 | 0 | 3 |
| PAWR | SLC6A2 | 0.690437 | 3 | 0 | 3 |
| PAWR | CENPE | 0.689164 | 3 | 0 | 3 |
| PAWR | RPUSD2 | 0.684957 | 3 | 0 | 3 |
| PAWR | PCID2 | 0.676343 | 3 | 0 | 3 |
| PAWR | PRKCI | 0.672317 | 4 | 0 | 4 |
| PAWR | GMCL1 | 0.671907 | 4 | 0 | 3 |
| PAWR | AAAS | 0.670296 | 3 | 0 | 3 |
| PAWR | KIAA1324L | 0.666383 | 3 | 0 | 3 |
| PAWR | FAM76B | 0.663781 | 3 | 0 | 3 |
| PAWR | SDHB | 0.663366 | 4 | 0 | 3 |
| PAWR | PUS7L | 0.659418 | 3 | 0 | 3 |
| PAWR | PDE6D | 0.65886 | 4 | 0 | 3 |
| PAWR | CREB1 | 0.654348 | 4 | 0 | 3 |
| PAWR | ORC1 | 0.651748 | 3 | 0 | 3 |
| PAWR | FARSA | 0.651423 | 3 | 0 | 3 |
For details and further investigation, click here
